Modern Pediatrics. Ukraine. (2025).6(150): 19-28. doi: 10.15574/SP.2025.6(150).1928
Kramarov S. O.¹, Seriakova I. Yu.¹, Yevtushenko V. V.¹, Yevtushenko O. M.^2
1Bogomolets National Medical University, Kyiv, Ukraine
²Kyiv City Children's Clinical Hospital № 2, Ukraine

For citation: Kramarov SO, Seriakova IYu, Yevtushenko VV, Yevtushenko OM. (2025). The use of Streptococcus salivarius K12 and Lactobacillus rhamnosus LGG in the treatment of streptococcal tonsillitis in children. Modern Pediatrics. Ukraine. 6(150): 19-28. doi: 10.15574/SP.2025.6(150).1928.
Article received: Jul 17, 2025. Accepted for publication: Sep 16, 2025.

Aim – to investigate the effectiveness of a combined probiotic containing bacteria of the genus Streptococcus salivarius K12 and Lactobacillus rhamnosus LGG in the treatment of streptococcal tonsillitis in children.
Materials and methods. A randomized, controlled, open, post-registration study was conducted. The study included 58 children diagnosed with streptococcal tonsillitis aged 1 to 17 years, who underwent inpatient treatment. Children were divided into 2 groups by randomization using the random number method. The control group consisted of 29 children who received standard treatment and the main group consisted of 29 children who received a combined probiotic Baktoblis+Lacto in addition to the protocol treatment. The study used clinical, laboratory and statistical methods to process the results obtained.
Results. We obtained a positive effect when using Baktoblis+Lacto. It was manifested by accelerated normalization of fever (average duration in the main group – 2.0±0.61 days, in the control group – 2.5±1.1 days), sore throat (1.92±0.67 days vs. 4.0±1.14 days, respectively), tonsil deposits (2.7±0.79 days vs. 3.5±0.86 days, respectively) and lymphadenopathy (2.8±0.51 days vs. 3.52±0.76 days, respectively). The frequency of antibiotic-associated diarrhea (AAD) in the control group was higher than in patients of the main group (the average duration in the control group – 3.6±0.62 days, in the main group – 2.1±0.55 days).
Conclusions. The combined probiotic (Streptococcus salivarius К12 + Lactobacillus rhamnosus LGG) in children with streptococcal tonsillitis promotes faster involution of disease symptoms and prevents the occurrence of AAD while taking antibiotics.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the institution mentioned in the paper. The informed consent of the patient was obtained for conducting the studies.
Keywords: Streptococcus salivarius K12, Lactobacillus rhamnosus, streptococcal tonsillitis, antibiotic-associated diarrhea, children.

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