Ukrainian Journal Health of Woman. 2025. 2(177): 97-100. doi: 10.15574/HW.2025.2(177).97100
Alatorskykh A. E
Ukrainian Military Medical Academy, Kyiv

For citation: Alatorskykh AE. (2025). Treatment of an acne patient with comorbid chronic chlamydial urethrocervicitis and immune deficiency. Ukrainian Journal Health of Woman. 2(177): 97-100. doi: 10.15574/HW.2025.2(177).97100
Article received: Jan 29, 2025. Accepted for publication: Apr 22, 2025.

Aim – demonastration of the possibility of using a patient-centered approach to medical care in clinical practice in the treatment of comorbid acne, chronic chlamydial urethrocervicitis and immunodeficiency of the first degree.
Clinical case. A patient-centered approach was used in the supervision of patient H., 25 years old, who turned to a multidisciplinary medical institution for specialized dermatovenereological care. The diagnosis was established: acne, papulo-pustular form, moderate severity, immune deficiency of the first degree, chronic chlamydial urethrocervicitis in the acute stage. Acne treatment was carried out with the help of isotretinoin and a set of cosmetic measures. Elimination of Chlamydia trachomatis was carried out by the consistent use of antibacterial drugs linezolid and levofloxacin, and immunomodulation was carried out with the preparation of antimicrobial regulatory peptides derived from bovine embryonic tissue.
Chlamydia trachomatis was completely eliminated from the genitourinary system, and immunogram indicators were almost completely restored to the level of reference values. At the end of the 6th month of treatment with isotretinoin as part of complex therapy, inflammatory rashes on the patient's face completely stopped, post-acne phenomena decreased significantly.
Conclusions. In a clinical case, the use of a patient-centered approach to medical care in  the treatment of comorbid acne, chronic chlamydial urethrocervicitis and immunodeficiency of the first degree was demonstrated. The success of treatment was due to well-chosen antibiotic therapy, the use of a complex of cosmetic measures, the use of isotretinoin in a dose appropriate to the clinical picture of acne and the use of Propes as an immunomodulatory means.
The study was conducted in accordance with the principles of the Declaration of Helsinki. Informed consent was obtained from participant.
The author declares no conflict of interest.
Keywords: acne, immune deficiency (immunodeficiency), comorbidity, patient-centered care, Chlamydia trachomatis.

REFERENCES

1. State expert center of the Ministry of Health of Ukraine. (2017). Acne. Evidence-based clinical practice: 100. URL: https://www.dec.gov.ua/wp-content/uploads/2019/11/akn_akne.pdf.

2. State formulary of medicinal products. (2018). Issue ten. K.: 1222.

3. Dyachuk DD, Moroz GZ, Gidzinska IM, Kravchenko AM. (2023). Implementation of a patient-oriented approach and improvement of the organization of medical care at the current stage (literature review). Clinical and preventive medicine. 1: 67-77. https://doi.org/10.31612/2616-4868.1(23).2023.10

4. Eichenfield DZ, Sprague J, Eichenfield LF. (2021). Management of acne vulgaris: A review. JAMA. 326: 2055. https://doi.org/10.1001/jama.2021.17633; PMid:34812859

5. Heng AHS, Chew FT. (2020). Systematic review of the epidemiology of acne vulgaris. Scientific Reports. 10(1): 5754. https://doi.org/10.1038/s41598-020-62715-3; PMid:32238884 PMCid:PMC7113252

6. Kuipers SJ, Nieboer AP, Cramm JM. (2020). Views of patients with multi-morbidity on what is important for patient-centered care in the primary care setting. BMC Family Practice. 21(1): 71. https://doi.org/10.1186/s12875-020-01144-7; PMid:32336277 PMCid:PMC7184691

7. Layton AM, Alexis A, Baldwin H, Bettoli V, Del Rosso J, Dirschka T et al. (2023). The Personalized Acne Treatment Tool – Recommendations to facilitate a patient-centered approach to acne management from the Personalizing Acne: Consensus of Experts. JAAD Int. 12: 60-69. https://doi.org/10.1016/j.jdin.2023.03.013; PMid:37274381 PMCid:PMC10236180

8. National Institute for Health and Care Excellence. (2021). Acne vulgaris: management NICE guideline [NG 198]. URL: https://www.nice.org.uk/guidance/ng198.

9. Chen J, Mullins CD, Novak P, Thomas SB. (2016). Personalized Strategies to Activate and Empower Patients in Health Care and Reduce Health Disparities. Health Educ Behav. 43(1): 25-34. https://doi.org/10.1177/1090198115579415; PMid:25845376 PMCid:PMC4681678

10. Fedorych P. (2020). Diagnostics and treatment of genital invasion caused by Trichomonas vaginalis and possibly other related species (Pentatrichomonas hominis and Trichomonas tenax) in patients with immunodeficiency. Georgian Medical News. 12(309): 81-85.

11. Vasam M, Korutla S, Bohara RA. (2023). Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology based advances. Biochem Biophys Rep. 36: 101578. https://doi.org/10.1016/j.bbrep.2023.101578; PMid:38076662 PMCid:PMC10709101

12. Wang Y, Zhu M, Wu S, Zheng H. (2022). Acne Comorbidities. Clin Cosmet Investig Dermatol. 15: 2415-2420. https://doi.org/10.2147/CCID.S392165; PMid:36387963 PMCid:PMC9661895