Modern Pediatrics. Ukraine. (2025).5(149): 41-48. doi: 10.15574/SP.2025.5(149).4148
Liubarets S. F.
Bogomolets National Medical University, Kyiv, Ukraine

For citation: Liubarets SF. (2025). Optimization of therapeutic and preventive measures in children with disorders of teeth formation. Modern Pediatrics. Ukraine. 5(149): 41-48. doi: 10.15574/SP.2025.5(149).4148.
Article received: Mar 13, 2025. Accepted for publication: Sep 10, 2025.

The results of existing studies on mineral metabolism and its impact on the development of dental caries as a complication of disorders of teeth formation in children are ambiguous and require in depth study.
Aim – to develop and evaluate the effectiveness of complexes of therapeutic and preventive measures aimed at preventing complications against the background of disorders of teeth formation in children, taking into account the mineralizing potential of the oral fluid.
Materials and methods. The study object is 289 children. The average age of the survey is 8.75±6.37 years. Two complexes of therapeutic and preventive measures have been developed with the inclusion of remineralizing drugs. Application – 2 years. Caries intensity was evaluated in accordance with the recommendations of the WHO Experts Committee (2013), taking into account «decayed, filled» (df) for temporary teeth, «decayed, missing, and filled» (DMF) for permanent teeth (df + DMF for mixed bite). The laboratory examination included the determination of the concentration of total calcium and phosphates in the oral fluid. Statistical data processing was performed using variational statistics methods.
Results. The complex of therapeutic and prophylactic measures with the inclusion of a water-based remineralizing row, which contains casein phosphopeptide-amorphic calcium phosphate has proved more effective. Two years after its introduction, the content of calcium in the oral fluid of children of all groups increased and was in the range from 1.17±0.11 to 1.48±0.15 mg/l, the level of phosphates also increased – from 3.37±0.16 to 4.08±0.46 mg/l; the intensity of dental caries in groups of individuals with systemic enamel hypoplasia, both with and without somatic pathology, as well as in children with molar-incisor enamel hypomineralization, not burdened by somatic pathology, was significantly lower compared to baseline indicators.
Conclusions. In order to prevent complications, including dental caries in children with disorders of teeth formation, two complexes of therapeutic and preventive measures were proposed, the effectiveness of which was evaluated in dynamics within 12-24 months. Carrying out preventive measures increased the level of mineral components of oral fluid and led to a decrease in the intensity of dental caries in children with disorders of teeth formation, which was more pronounced when using a complex with the inclusion of a water-based remineralizing cream containing casein phosphopeptide-amorphous calcium phosphate.
The study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Bioethics Committee of the mentioned institution. Informed consent was obtained from all participants.
The author declares no conflict of interest.
Keywords: children, teeth, caries, hypoplasia, oral fluid, calcium, phosphates.

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