Ukrainian Journal Health of Woman. 2025. 2(177): 17-25. doi: 10.15574/HW.2025.2(177).1725
Kuzmych O. S.¹, Krotik O .I.², Zarichanska Kh. V.^1
1Shupik National University of Healthcare of Ukraine, Kyiv
²LLC "ISIDA-IVF", Kyiv, Ukraine

For citation: Kuzmych OS, Krotik OI, Zarichanska KhV. (2025). Features of the endocrinological status of patients who have suffered endometritis after cesarean section. Ukrainian Journal Health of Woman. 2(177): 17-25. doi: 10.15574/HW.2025.2(177).1725
Article received: Jan 28, 2025. Accepted for publication: Apr 22, 2025.

Aim – to identify the main types of disorders of the functional state of the hypothalamic-pituitary brain, hormonal function of the ovaries and adrenal glands in women who have suffered endometritis after cesarean section.
Materials and methods. Examined 60 women who had endometritis after cesarean section (CS) were examined: Group I – 40 women who received hormone replacement therapy (HRT), Group II – 20 women who did not receive it. The control group (CG) consisted of 20 women who had delivered by CS without complications in the postoperative period. Clinical and laboratory hormonal examination was carried out for 2 years with an interval of every 6 months. Statistical processing of research results was carried out using standard programs "Microsoft Excel 5.0" and "Statistica 8.0".
Results. Тhen examining patients 6 months after delivery in the first phase of the menstrual cycle (MC), we observed an increase in the content of estradiol in the Groups 1 and 2; prolactin and cortisol against the background of a decrease in follicle-stimulating hormone (FSH). The use of HRT in the complex of restorative treatment allowed, after 12 months, to normalize the content of estradiol to 863.7±72.5 pmol/l, progesterone – to 30.2±1.8 pmol/l; against the background of generally accepted therapy in the Group II of patients, the content of estradiol did not change, and progesterone remained at 10.4±1.0 pmol/l. Further endocrinological studies conducted after 12 months and 24 months indicate the normalization of the above changes when using the restorative treatment developed by us in patients of the Group I.
Conclusions. HRT for 6 months in the complex of restorative treatment of women who suffered endometritis after CR contributed to a significant decrease in the level of estradiol, prolactin, cortisol against the background of an increase in FSH the first phase of the MC and a significant decrease in the level of luteinizing hormone, prolactin, cortisol, aldosterone with a simultaneous increase in the level of progesterone in the second phase of the MC.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the institution mentioned in the paper. The informed consent of the patient was obtained for conducting the studies.
No conflict of interests was declared by the authors.
Keywords: cesarean section, endometritis, neuroendocrine disorders, hormonal system status, long-term consequences of endometritis, rehabilitation therapy, hormone replacement therapy.

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