SOVREMENNAYA PEDIATRIYA.2016.4(76):14-17; doi10.15574/SP.2016.76.14

Drug disease among children: clinical lecture

Berezhniy V., Romankevych I. 
P.L.Shupik National Medical Academy of Postgraduate Education, Kiev, Ukraine

The widespread use of drugs led to the emergence of the disease known as «drug disease». Тhe article clinical manifestations of the drug disease, pathophysiological mechanisms its development and influence of various factors, such as drug interactions, drug"food interaction and the drug-patient interaction, peculiarity of child body, which may affect the development of adverse reactions and cause the drug disease.

Key words: drug disease, adverse reactions, drug.

REFERENCES 
1. Drug disease http://www.pharmencyclopedia.com.ua/article/2077/likarska-xvoroba%. 
2. Drug disease. http://www.intranet.tdmu.edu.ua/data/cd/infect_desease/html/Med_hv/Med_hv.htm. 
3. Drug disease. http://www.referatu.net.ua/referats/20/3718. 
4. Drug disease. http://www.spravochnik.vse-zabolevaniya.ru/ua/vnutrishnihvoroby/medykamentozna-hvoroba.html. 
5. Ilchenko LJ, Korovych TI. 2013. Hepatic drug disease. The role of haepatoprotection in her therapy. Medical council. 10: 32—37. 
6. Knyazkova II. 2015. Clinical pharmacology medication in children: safety of drug therapy. The Health of Ukraine. 4(35): 37—39. // 
7. Drug disease in side effect of rug problem: current state. http://www.ilive.com.ua/health/lekarstvennaya-bolezn-v-probleme-pobochnogo-deystviya-lekarstv-sovremennoe-sostoyanie_79548i15940.html. 
8. Drug-Induced Diseases. http://www.worstpills.org /public/page.cfm?op_id=84 — 41k. 
9. Dumbreck S, Flynn А, Nairn M et al. 2015. Drug-disease and drug-drug interactions: systematic examination of recommendations in 12 UK national clinical guidelines. BMJ: 350:h949. 
10. Gruchalla RS. Clinical assessm ent of drug-induced disease. Lancet. 356; 9240: 1505—1511. 
11. Fenstein J, Dai D, Zhong W et al. 2015. Drug-Drug Interactions in Infant, Child, and Adolescent Patients in Children's Hospitals. Pediatrics. 135(1): 99—108. 
12. Hussar DA. Drug interaction. Clinical Pharmacology. Merck Manual. http://www.Merckmanual.com. Professional. 
13. Koo LW. 2007. Pediatric drug interaction. http://www.nursing.advaceweb.com. CE-Article. 
14. Martinbiancho J, Zuckermann J, Dos Santos J, Silva MM. Profile of drug interactions in hospitalized children. Pharmacy Practice. version On-line ISSN 1886—3655. 
15. Qato D, Alexandr GC, Conti RM et al. 2008. Use of prescriction and over-the-counter medications and dietary supplements among older adults in the United States. JAMA. 300: 2867—2878. 
16. Wong IC, Ghaleb MA, Frankling BD, Barder N. 2004. Incidence and nature of dosing errors in paediatric medication: a systematic review. Drug Saf. 27(9): 661—670. http://dx.doi.org/10.2165/00002018-200427090-00004; PMid:15230647