SOVREMENNAYA PEDIATRIYA.2016.2(74):66-72; doi 10.15574/SP.2016.74.66

The application of plant origin immunomodulator in the complex treatment of diseases in childhood

Abaturov A. E., Borysova T. P. 
SI «Dnepropetrovsk Medical Academy, Ministry of Health of Ukraine»

The article describes the results of experimental investigations confirming the presence of immunomodulating activity on innate and adaptive immunity in the phytodrug Imupret. Data about clinical and immunological efficacy of the drug Imupret for the treatment of respiratory system, gastrointestinal tract and kidneys diseases in children is presented.

Key words: children, diseases, immunotropic drugs, herbal medicine.

REFERENCES

1. Abaturov AE, Volosovets AP, Yulish EI. 2011. Initsiatsiya vospalitelnogo protsessa pri virusnyih i bakterialnyih zabolevaniyah, vozmozhnosti i perspektivyi medikamentoznogo upravleniya. Harkov: 390.

2. Abaturov AE, Agafonova EA. 2015. Sovremennyie vozmozhnosti fitoimmunomodulyatsii pri lechenii zabolevaniy u detey. Zdorov'ya Ukrayini. 3(34), Pediatriia: 24—26.

3. Abaturov AЕ, Gerasimenko ON. 2011. Medication regulation of active mechanisms of nonspecific defense mucosal digestive tract in children with chronic helicobacter pylori8associated gastroduodenitis. Sovremennaya pediatriya. 4: 130—133.

4. Brandis T. 2008. Kompaniya «Bionorika SE» — lider v proizvodstve fitofarmatsevticheskih preparatov. Novosti meditsinyi i farmatsii. 18(259).

5. Melnikov OF, Krivohatskaya LD, Timchenko MD i dr. 2012. Vliyanie fitoimmunomodulyatora Imupret^® na faktoryi protivovirusnogo immuniteta in vitro. RinologIya. 2: 9—13.

6. Tsodikova OA, Harbar KB, Barchan AS, Babenko OO. 2012.Vplyv suchasnykh fitoimunomoduliatoriv na stan mukozalnoho imunitetu u ditei. Liky — liudyni. Suchasni problemy stvorennia, vyvchennia ta aprobatsii likarskykh zasobiv. Mater XXIX vseukr nauk-prakt konf z mizhnar uch. Kharkiv: 182.

7. Marushko YuV, Hyshchak TV, Lysovets OV, Marushko YeIu. 2015. Dosvid zastosuvannia imunomoduliuiuchoi terapii v kompleksnomu likuvanni khronichnoho tonzylitu v ditei. Zdorove rebenka. 1(60): 49–54.

8. Drynov GI. 2013. Clinical and immunological characteristics and effectiveness of conservative treatment of chronic tonsillitis in children. Sovremennaya pediatriya. 6(54): 116—120.

9. Dryinov GI, Ivanyushina OK, Dyakova FN. 2001. Rezultatyi lecheniya detey s hronicheskim tonzillitom preparatom Tonzilgon®N. Detskiy doktor. 1: 67—69.

10. Zupanets IA, Saharova TS, Bezuglaya NP. 2014. Rastitelnyie immunokorrektoryi v profilaktike i lechenii ORVI. LIki Ukrayini. 9(185): 36—40.

11. Ivanov DD, Kushnirenko SV. 2014. Immunoreabilitatsiya v kompleksnoy terapii hronicheskogo glomerulonefrita u detey. Pochki. 4(10): 13—16.

12. Melnikov OF, Peleshenko NA, Zabolotnaya DD, Ryilskaya OG. 2013. Immunomodulyatsiya fitopreparatami v terapii vospalitelnyih zabolevaniy verhnih dyihatelnyih putey (eksperimentalnyie i kliniko-immunologicheskie issledovaniya). Kiev: 108.

13. Melnikov OF, Ryilskaya OG, Tsimar AV, Peleshenko NA. 2013. Imupret® kak fitoimmunomodulyator i adaptogen. Medical Nature. 2(14): 70—74.

14. Instruktsiia iz zastosuvannia preparatu Imupret UA/6909/02/01. Nakaz MOZ Ukrainy № 568 vid 26.07.2012.

15. Kaladze NN, Slobodyan EI. 2013. Immunorehabilitation of children with chronic pyelonephritis in the resort conditions. Sovremennaya pediatriya. 1(49): 142—148.

16. Katarbaev AK, Batyirhanov ShK, Berdenova GT. 2013.Rezultatyi klinicheskogo primeneniya rastitelnogo preparata imupret v kompleksnoy terapii pri ostryih kishechnyih infektsiyah u detey. Vestnik KazNMU. 4(1): 118—120.

17. Kovalenko LP, Shilaeva EV, Kolchenko II. 2008. Immunokorrigiruyuschie svoystva fitopreparata Tonzilgon®N. Rossiyskiy med. zhurn. 25; 16: 1677—1679.

18. Kombinirovannyiy rastitelnyiy preparat ukreplyaet immunitet. Medical Nature. 2011. 8: 30—32.

19. Melnikov OF, Ryilskaya OG. 2005. Eksperimentalnoe issledovanie immunomoduliruyuschih svoystv Tonzilgona N in vitro. Zhurn vushnih, nosovih I gorlovih hvorob. 3: 74—76.

20. Morenko MA. 2012. Ispolzovanie preparata Imupret® (Tonzilgon®N) v kompleksnoy terapii bronhialnoy astmyi u chasto boleyuschih detey. Zdorov'ya Ukrayini. 4(12): 48—51.

21. Ovcharenko LS, Vertehel AO, Andriienko TH ta in. 2009. Novyi pidkhid do imunokorektsii u ditei. Suchasni medychni tekhnolohii. 3: 11—18.

22. Popovych VI, Koshel IV. 2014. Osoblyvosti etiolohii, patohenezu, klinichnoho perebihu ta likuvannia hostroho virusnoho nazofarynhitu v suchasnykh umovakh. Zhurnal vushnykh, nosovykh i horlovykh khvorob. 6: 57—68.

23. Rimmele M. 2011. Zdorove v sezon prostud blagodarya kombinirovannomu rastitelnomu preparatu. Medical nature. 5: 29—31.

24. Slobodyan EI. 2013. Katamnez detey, bolnyih hronicheskim pielonefritom, posle kompleksnogo sanatorno-kurortnogo lecheniya. Zdorove rebenka. 6(49): 94—99.

25. Smirnova GI. 2001. Opyit primeneniya Sinupreta i Tonzilgona N dlya profilaktiki i lecheniya ostryih respiratornyih zabolevaniy u chasto boleyuschih detey. Detskiy doktor. 1: 25—29.

26. Fedorova OA. 2014. Fitoimmunokorrektsiya v formate sovremennyih meditsinskih tehnologiy i standartov. Imupret® — opyit i perspektivyi klinicheskogo primeneniya. Ukrayinskiy med chasop. 2(100): 87—94.

27. Haitov RM, Pinegin BV. 2000. Sovremennyie immunomodulyatoryi: osnovnyie printsipyi ih primeneniya. Immunologiya. 5: 4—7.

28. Tsodikova OA. 2012. Effect of phytopreparation «imupret» on the index data of peripheral blood in children with recurrent respiratory tract infections. Sovremennaya pediatriya. 4: 122—127.

29. Berger T. 2008. Tolerability and efficacy of a herbal combination preparation in children and adolescents with recurrent infections of the upper respiratory tract. MMW Fortschr Med. 26(150); Suppl 2: 85—90.

30. Hostanska K, Melzer J, Amon A, Saller R. 2011, Mar. Suppression of interleukin (IL)-8 and human beta defensin-2 secretion in LPS-and/or IL-1β-stimulated airway epithelial A549 cells by a herbal formulation against respiratory infections (BNO 1030). J Ethnopharmacol. 24;134 (2): 228—233.