- The effectiveness of intravenous administration of iron sucrose to parturient women with iron metabolism disorders after abdominal delivery
The effectiveness of intravenous administration of iron sucrose to parturient women with iron metabolism disorders after abdominal delivery
Ukrainian Journal of Perinatology and Pediatrics. 2026.1(105): 11-16. doi: 10.15574/PP.2026.1(105).1116
Davydova Iu. V.1, Lymanska A. Yu.1,2, Kravets O. M.1, Landyak Iu. V.1
1SI «Ukrainian center of maternity and childhood of the NAMS of Ukraine», Kyiv
2Bogomolets National Medical University, Kyiv, Ukraine
For citation: Davydova IuV, Lymanska AYu, Kravets OM, Landyak IuV. (2026). The effectiveness of intravenous administration of iron sucrose to parturient women with iron metabolism disorders after abdominal delivery. Ukrainian Journal of Perinatology and Pediatrics. 1(105): 11-16. doi: 10.15574/PP.2026.1(105).1116.
Article received: Jan 08, 2026. Accepted for publication: Feb 16, 2026.
Aim – to evaluate the effectiveness of treatment of iron metabolism disorders with iron sucrose in case of increased blood loss during cesarean section.
Materials and methods. The study included 156 women aged 22-38 years with an initial hemoglobin level of 92-105 g/l and intraoperative blood loss of 650-850 ml (≈0.6-0.8% of body weight). Of these, 62 women with hemoglobin in the 3rd trimester of pregnancy 88-99 g/l (Group I), 62 women with hemoglobin 100-105 g/l (Group II). All women in groups I and II were administered iron saccharate (Sufer, Yuriya-Pharm) in the early postoperative period, Group III consisted of 32 parturient women with hemoglobin 88-99 g/l, who were prescribed ferrous sulfate 200 mg Fe²⁺ daily for 14 days.
Results. According to the fatigue assessment, women in all groups felt fatigue after abdominal delivery. In Group II, the fatigue index on day 2 was much lower than in Groups I and III. A rapid recovery of hemoglobin and ferritin was observed in Groups I and II 48 hours after drug administration, but the indicators of Group II reflected a faster rate of recovery of iron metabolism in contrast to the retention of increased fatigue in women in Group III, which lasted longer and was more pronounced.
Conclusions. Early use of intravenous iron sucrose in combination with anemia and moderate blood loss after cesarean section promotes accelerated recovery of hemoglobin and iron stores, reduces clinical manifestations of posthemorrhagic syndrome and reduces the frequency of blood transfusions.
The study was carried out in accordance with the principles of the Declaration of Helsinki. The informed consent of the children's parents was obtained for the research.
No conflict of interests was declared by the authors.
Keywords: pregnancy, cesarean section, bleeding, anemia, iron deficiency.
REFERENCES
1. Antoniou E, Orovou E, Iliadou M, Sarella A, Palaska E, Rigas N et al. (2021). The Kind of Conception Affects the Kind of Cesarean Delivery in Primiparous Women. Mater. Sociomed. 33: 188-194. https://doi.org/10.5455/msm.2021.33.188-194; PMid:34759776 PMCid:PMC8565429
2. Auerbach M, Abernathy J, Juul S, Short V, Derman R. (2021). Prevalence of iron deficiency in first trimester, nonanemic pregnant women. J Matern Fetal Neonatal Med. 34(6): 1002-1005. https://doi.org/10.1080/14767058.2019.1619690; PMid:31154873
3. Benson AE, Shatzel JJ, Ryan KS, Hedges MA, Martens K et al. (2022, Dec). The incidence, complications, and treatment of iron deficiency in pregnancy. Eur J Haematol. 109(6): 633-642. https://doi.org/10.1111/ejh.13870; PMid:36153674 PMCid:PMC9669178
4. Breymann C. (2015). Iron deficiency anemia in pregnancy. Semin Hematol. 52(4): 339-347. https://doi.org/10.1053/j.seminhematol.2015.07.003; PMid:26404445
5. Davydova IuV, Ogorodnyk AA, Limancka AYu, Bayder AK, Butenko LP. (2017). Prophylactics of obstetric disorders in anemia of chronic disease. Perinatologiya i pediatriya. 2(70): 37-41. https://doi.org/10.15574/PP.2017.70.37
6. Davydova YuV, Butenko LP, Lymanska AIu. (2017). Sposib dyferentsiiovanoi korektsii zalizodefitsytu ta likuvannia zalizodefitsytnoi anemii u vahitnykh ta porodil z vrodzhenymy vadamy sertsia ta sertsevoiu nedostatnistiu. Patent na korysnu model № 113985 vid 27.02.2017.
7. Davydova YuV, Voronkov LG, Ogorodnik АO, Pashynny AV, Mokryk АN, Butenko LP. (2014). Iron deficiency and its correction in pregnant women having heart failure. Health of woman. 1(87): 60-62.
8. Dennis AT, Ferguson M, Jackson S. (2022). The prevalence of perioperative iron deficiency anaemia in women undergoing caesarean section. Perioperative Medicine 11(1): 36. https://doi.org/10.1186/s13741-022-00268-x; PMid:35922876 PMCid:PMC9351116
9. De Vries PLM, Verspyck E, Morau E, Saucedo M, Deneux-Tharaux C et al. (2024). Maternal Mortality Due to Obstetric Hemorrhage by Surgical Injury during Cesarean Section: A Nationwide Study. Acta Obstet. Gynecol. Scand. 103: 1877-1887. https://doi.org/10.1111/aogs.14917; PMid:39021333 PMCid:PMC11324917
10. FACIT Group. (2021). Manual for the Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System. URL: https://www.facit.org/measures/FACIT-F.
11. Hidalgo MJC, Blanco-Carnero JE, González LC. (2025). Complications in Cesarean Sections: A National Survey of Obstetric Protocols and Outcomes in Spain. PLoS ONE. 20: e0330352. https://doi.org/10.1371/journal.pone.0330352; PMid:40901865 PMCid:PMC12407456
12. Lewkowitz AK, Stout MJ, Cooke E et al. (2022). Intravenous versus Oral Iron for Iron-Deficiency Anemia in Pregnancy (IVIDA): A Randomized Controlled Trial. Am J Perinatol. 39(8): 808-815. https://doi.org/10.1055/s-0041-1740003; PMid:34839481
13. MOZ Ukrainy. (2015). Zalizodefitsytna anemiia. Unifikovanyi klinichnyi protokol pervynnoi ta vtorynnoi (spetsializovanoi) medychnoi dopomohy: 26.
14. Murrin, EM, LeBeau OS, Singer L, Kassab MA, Kalan P, Costanzo J et al. (2025). Effectiveness and Safety of Intravenous Iron Therapy in Outpatient Obstetrical Clinic for Treatment of Iron-Deficiency Anemia During Pregnancy. Pregnancy. 1: e70067. https://doi.org/10.1002/pmf2.70067
15. Niranjana R, Raja Rajeswari KS . (2018). Study of effectiveness, tolerability and safety of intravenous iron sucrose in postnatal women. Int J Reprod Contracept Obstet Gynecol. 7(11): 4471-4476. https://doi.org/10.18203/2320-1770.ijrcog20184245
16. Ogorodnyk AO, Limanskaya АYu, Butenko LP, Davydova IuV. (2018). Correction of iron deficiency in pregnant women with congenital heart defects, heart failure and anaemia Perinatologiya i pediatriya. 3(75): 31-34. https://doi.org/10.15574/PP.2018.75.31
17. Pavord S, Daru J, Prasannan N, Robinson S, Stanworth S, Girling J. (2020). UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol. 188(6): 819-830. https://doi.org/10.1111/bjh.16221; PMid:31578718
18. Sirsam SS, Patil BV, Sanap MB. (2025). Comparison of parenteral iron sucrose and oral iron preparations in the treatment of postpartum anemia at tertiary health care centre: randomised controlled trial study. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. 15(1): 222-225. https://doi.org/10.18203/2320-1770.ijrcog20254284
19. Tang G, Lausman A, Abdulrehman J et al. (2019). Prevalence of iron deficiency and iron deficiency anemia during pregnancy: a single centre Canadian study. Blood. 134: 3389. https://doi.org/10.1182/blood-2019-127602
20. Thomaidi S, Sarantaki A, Tzitiridou Chatzopoulou M, Orovou E, Jotautis V, Papoutsis D. (2025, Nov 15). The Rising Global Cesarean Section Rates and Their Impact on Maternal and Child Health: A Scoping Review. J Clin Med. 14(22): 8102. https://doi.org/10.3390/jcm14228102; PMid:41303138 PMCid:PMC12653877
21. Tolkien Z, Stecher L, Mander AP, Pereira DIA, Powell JJ. (2015). Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PLoS One. 10(2): e0117383. https://doi.org/10.1371/journal.pone.0117383; PMid:25700159 PMCid:PMC4336293
22. Ubom AE, Begum F, Ramasauskaite D, Nieto-Calvache AJ, Oguttu M, Nunes I et al. (2025, Dec). FIGO good practice recommendations on anemia inpregnancy, to reduce the incidence and impact of postpartumhemorrhage (PPH). 171(3): 993-1007. Epub 2025 Oct 1. https://doi.org/10.1002/ijgo.70529; PMid:41031541 PMCid:PMC12640178
23. Wigert H, Nilsson C, Dencker A, Begley C, Jangsten E, Sparud-Lundin C et al. (2019). Women's Experiences of Fear of Childbirth: A Metasynthesis of Qualitative Studies. Int. J. Qual. Stud. Health Well-Being. 15: 1704484. https://doi.org/10.1080/17482631.2019.1704484
PMid:31858891 PMCid:PMC6968519
