Ukrainian Journal of Perinatology and Pediatrics. 2025.3(103): 7-11. doi: 10.15574/PP.2025.3(103).711
Davydova Iu. V.¹ , Lymanska A. Yu.^1,2,, Dziuba O. M.¹, Landiak Yu. V.^1
1SI «Ukrainian center of maternity and childhood of the NAMS of Ukraine», Kyiv
²Bogomolets National Medical University, Kyiv, Ukraine

For citation: Davydova IuV, Lymanska AYu, Dziuba OM, Landiak YuV. (2025). Effectiveness of a comprehensive management approach for pelvic congestion syndrome. Ukrainian Journal of Perinatology and Pediatrics. 3(103): 7-11. doi: 10.15574/PP.2025.3(103).711.
Article received: Jul 18, 2025. Accepted for publication: Sep 15, 2025.

Chronic pelvic pain is a common symptom in obstetric and gynecologic practice; in 15–40% of reproductive-age women it is caused by pelvic congestion syndrome (PCS). This syndrome is considered a form of chronic venous disease; among conservative approaches there is growing interest in venoactive flavonoids (diosmin, hesperidin, anthocyanins, triterpenes of Centella asiatica) with venotonic, anti-inflammatory, and antioxidant effects.
Aim – to investigate the effectiveness of pharmacological treatment with the dietary supplement Flego in women with PCS by comparing changes in venous diameter and quality of life before and after therapy.
Materials and methods. Sixty women aged 25-38 years with PCS were included. All participants received Flego plus lifestyle modification (healthy diet, cessation of harmful habits, increased physical activity, Pilates exercises). Assessments included pelvic vein diameter (ultrasound), quality of life by Pelvic Varicose Vein Questionnaire (PVVQ) and pain by Visual Analogue Scale (VAS) at baseline and at 3 months.
Results. The baseline mean venous diameter was 8.56±1.38 mm (range 6.54-11.65 mm). After 3 months: in 48 (80.0%) patients the diameter decreased to 5.86±1.48 mm; in 10 (16.7%) there was a moderate decrease to 7.12±1.31 mm; in 2 (3.3%) no change was recorded. VAS pain scores decreased from 6.46±1.89 points to 2.62±1.46 points; quality of life by PVVQ improved from 56.32±12.51 points to 27.43±10.11 points.
Conclusions. The combination of Flego with lifestyle modification was associated with a reduction in pelvic vein diameter in 80% of patients, a significant decrease in pain, and improved quality of life. These findings support this approach as a conservative option in early stages of PCS.
The study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the institution’s local ethics committee. Informed consent was obtained from patients.
The authors declare no conflict of interest.
Keywords: chronic pelvic pain, pelvic varicose veins, ultrasonography, venoactive flavonoids, diosmin, hesperidin, quality of life (PVVQ).

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