- Prognostic value of platelet indices in children with haemostatic disorders induced by herpetic infection and their relation to the inflammatory process activity
Prognostic value of platelet indices in children with haemostatic disorders induced by herpetic infection and their relation to the inflammatory process activity
Ukrainian Journal of Perinatology and Pediatrics. 2025.2(102): 60-65. doi: 10.15574/PP.2025.2(102).6065
Dudnyk V. M.1, Kuz O. V.2
1National Pirogov Memorial Medical University, Vinnytsia, Ukraine
2VO «St. Mykolai Hospital» CNO «TMO No. 1 Lviv», Ukraine
For citation: Dudnyk VM, Kuz OV. (2025). Prognostic value of platelet indices in children with haemostatic disorders induced by herpetic infection and their relation to the inflammatory process activity. Ukrainian Journal of Perinatology and Pediatrics. 2(102): 60-65. doi: 10.15574/PP.2025.2(102).6065.
Article received: Mar 16, 2025. Accepted for publication: Jun 15, 2025.
Platelets are the smallest but highly reactive morphological components of blood, primarily involved in fibrosis and maintenance of normal haemostasis, but there is also considerable evidence of their multifunctionality, including their involvement in inflammation
Aim – to assess the prognostic significance of changes in platelet indices in children with haemostatic disorders induced by herpes infection.
Materials and methods. We examined 100 children aged 0-18 years with haemostatic disorders induced by herpetic infections. In addition to general clinical examinations, platelet indices, namely mean platelet volume (MPV), thrombocrit (PCT), platelet large coefficient (P-LCR) and platelet distribution width (PDW), all subjects underwent determination of levels of C-reactive protein, interleukin-1 and interleukin-6, endothelin-1, and polymerase chain reaction of herpes viruses of 8 types.
Results. It was determined that at MPV values below 5.79 fl there was a significant risk of severe thrombocytopenia and vasopathy, and at values above 13.62 fl – severe thrombocytosis. At PCT levels within the third to fourth quartile, there was a significant risk of severe haemostatic disorders. A P-LCR above 53.08% was a prognostic marker for the development of severe thrombocytopenia and vasopathy, and less than 3.11% for severe thrombocytosis.
Conclusions. The study found that platelet indices are prognostic markers of the severity of haemostatic disorders induced by herpes infection in children. Thus, a decrease in MPV and PDW is a prognostic marker of severe thrombocytopenia and vasopathy, and an increase in PCT and P-LCR is a prognostic marker of severe haemostatic disorders.
The study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee for all participants. Informed consent was obtained from patients (parents of children or their guardians).
The authors declare no conflict of interest.
Keywords: children, hemostasis, platelet indexes, pathology of hemostasis, herpetic infections.
REFERENCES
1. Afsar N, Afroze IA, Tahniath H, Abid Z. (2017). Role of mean platelet volume as an adjunct in evaluation of acute inflammation. Annals of Pathology and Laboratory Medicine. 4(4): A466-A469. https://doi.org/10.21276/APALM.1486
2. Delgado-García G, Galarza-Delgado DÁ, Colunga-Pedraza I et al. (2016). Mean platelet volume is decreased in adults with active lupus disease. Revista Brasileira de Reumatologia. 56(6): 504-508. https://doi.org/10.1016/j.rbre.2016.03.003; PMid:27914597
3. Dobrijević D, Antić J, Rakić G, Andrijević L, Katanić J, Pastor K. (2022). Could platelet indices have diagnostic properties in children with COVID-19? J Clin Lab Anal. 36(12): e24749. Epub 2022 Nov 13. https://doi.org/10.1002/jcla.24749; PMid:36371787 PMCid:PMC9756979
4. Golwala ZM, Shah H, Gupta N, Sreenivas V, Puliyel JM. (2016). Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet Count and Plateletcrit (PCT) as predictors of in-hospital paediatric mortality: a case-control Study. Afr Health Sci. 16(2): 356-362. https://doi.org/10.4314/ahs.v16i2.3; PMid:27605950 PMCid:PMC4994558
5. Korniluk A, Koper-Lenkiewicz OM, Kamińska J, Kemona H, Dymicka-Piekarska V. (2019, Apr 17). Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions. Mediators Inflamm. 2019: 9213074. https://doi.org/10.1155/2019/9213074; PMid:31148950 PMCid:PMC6501263
6. Koupenova M, Corkrey HA, Vitseva O, et al. (2021). SARS‐CoV‐2 initiates programmed cell death in platelets. Circ Res. 129(6): 631‐646. Epub 2021 Jul 23. https://doi.org/10.1161/CIRCRESAHA.121.319117; PMid:34293929 PMCid:PMC8409903
7. Linke B, Schreiber Y, Picard-Willems B et al. (2017). Activated platelets induce an anti-inflammatory response of monocytes/macrophages through cross-regulation of PGE2 and cytokines. Mediators of Inflammation. 2017: 14. https://doi.org/10.1155/2017/1463216; PMid:28592915 PMCid:PMC5448075
8. Schwertz H, Koster S, Kahr WHA et al. (2010). Anucleate platelets generate progeny. Blood. 115(18): 3801-3809. https://doi.org/10.1182/blood-2009-08-239558; PMid:20086251 PMCid:PMC2865870
9. Senchenkova EY, Komoto S, Russell J et al. (2013). Interleukin-6 mediates the platelet abnormalities and thrombogenesis associated with experimental colitis. American Journal of Pathology. 183(1): 173-181. https://doi.org/10.1016/j.ajpath.2013.03.014; PMid:23673000 PMCid:PMC3702741