• Bacterial vaginosis as a factor in pregnancy complications (literature review)
en To content Full text of article

Bacterial vaginosis as a factor in pregnancy complications (literature review)

Ukrainian Journal of Perinatology and Pediatrics. 2024. 3(99): 134-141. doi: 10.15574/PP.2024.3(99).134141
Рrуlutska A. B., Martynova L. I., Kisilenko О. L., Govsieiev D. O.
Bogomolets National Medical University, Kyiv, Ukraine

For citation: Рrуlutska AB, Martynova LI, Kisilenko ОL, Govsieiev DO. (2024). Bacterial vaginosis as a factor in pregnancy complications (literature review). Ukrainian Journal of Perinatology and Pediatrics. 3(99): 134-141. doi: 10.15574/PP.2024.3(99).134141.
Article received: Jun 28, 2024. Accepted for publication: Sep 04, 2024.

Aim – to analyze the current literature on etiopathogenetic factors, diagnosis and treatment of bacterial vaginosis in cases of vaginosis and improve treatment methods for this pathology Changes in the size of the body due to the passage of vaginosis.
The article shows the relevance of the problem of bacterial vaginosis in the whole world. The etiopathogenetic factors that determine the cause of illness during pregnancy are examined. The emphasis is placed on complications caused by bacterial vaginosis in vaginal patients. The effectiveness of methods for diagnosing bacterial vaginosis in women has been analyzed. The prospects for the use of antibacterial drugs and antibiotics in pregnant women with bacterial vaginosis are examined. The tactics for preventing pregnant women with bacterial vaginosis have been assessed.
Conclusions. Despite modern diagnostics and pharmacological means, the problem of detecting and treating bacterial vaginosis in pregnant women remains difficult, as the morphological polymorphism, species diversity of pathogens complicates diagnosis, and the wide spread of drug-resistant strains reduces the effectiveness of treatment, leading to relapses of the disease. During pregnancy in patients with BV, only women with persistent symptoms are subject to observation and in cases where treatment is prescribed to reduce the risk of premature birth and other complications, re-diagnosis should be carried out after one month and further treatment should be offered in case of recurrence of bacterial vaginosis.
The authors declare no conflicts of interest.
Keywords: women, bacterial vaginosis, pregnancy, etiology, diagnosis, treatment.

REFERENCES

1. Alhasan MM, Cait AM, Heimesaat MM, Blaut M, Klopfleisch R, Wedel A et al. (2020, Aug). Antibiotic use during pregnancy increases offspring asthma severity in a dosedependent manner. Allergy. 75(8): 1979-1990. https://doi.org/10.1111/all.14234; PMid:32064643

2. Amir M, Brown JA, Rager SL, Sanidad KZ, Ananthanarayanan A, Zeng MY. (2020). Maternal Microbiome and Infections in Pregnancy. Microorganisms. 8(12): 1996. https://doi.org/10.3390/microorganisms8121996; PMid:33333813 PMCid:PMC7765218

3. Beerepoot MA, ter Riet G, Nys S, van der Wal WM, de Borgie CA, de Reijke TM et al. (2012, May 14). Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. Arch Intern Med. 172(9): 704-712. https://doi.org/10.1001/archinternmed.2012.777; PMid:22782199

4. Callahan BJ, Di Giulio DB, Goltsman DSA, Sun CL, Costello EK, Jeganathan P et al. (2017). Replication and refinement of a vaginal microbial signature of preterm birth in two racially distinct cohorts of us women. Proc. Natl. Acad. Sci. USA. 114: 9966-9971. https://doi.org/10.1073/pnas.1705899114; PMid:28847941 PMCid:PMC5604014

5. Cao B, Stout MJ, Lee I, Mysorekar IU. (2014). Placental microbiome and its role in preterm birth. Neoreviews. 15: e537-e545. https://doi.org/10.1542/neo.15-12-e537; PMid:25635174 PMCid:PMC4307601

6. Colonna C, Steelman M. (2020). Amsel Criteria. StatPearls, Jul. 13.

7. Daskalakis GJ, Karambelas AK. (2017). Vaginal probiotic administration in the management of preterm premature rupture of membranes. Fetal Diagn Ther. 42(2): 92-98. https://doi.org/10.1159/000450995; PMid:27744438

8. Dargahi N, Johnson J, Donkor et al. (2019). Immunomodulatory effects of probiotics can they be used to treat allergies and autoimmune diseases? Maturitas. 199: 25-38. https://doi.org/10.1016/j.maturitas.2018.11.002; PMid:30502748

9. De Backer E, Dubreuil L, Brauman M. (2010, May). In Vitro Activity of Secnidazole Against Atopobium Vaginae, an Anaerobic Pathogen Involved in Bacterial Vaginosis. Clin Microbiol Infect. 16(5): 470-472. https://doi.org/10.1111/j.1469-0691.2009.02852.x; PMid:19548924

10. EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP). (2012, Jun). Guidance on the assessment of bacterial susceptibility to antimicrobials of human and veterinary importance. EFSA Journal. 10(6): 2740. https://doi.org/10.2903/j.efsa.2012.2740

11. Elshaghabee FMF, Rokana N, Gulhane RD. (2017). Bacillus as potential probiotics status, concerns and future perpectives Front. Microbiol. 8: 1490. https://doi.org/10.3389/fmicb.2017.01490; PMid:28848511 PMCid:PMC5554123

12. Espinosa E. (2015). Philippines survey on the use of EcoVag vaginal capsule usage and acceptance and its effect on patients with Bacterial vaginosis: 1-6.

13. Fettweis JM, Serrano MG, Brooks JP, Edwards DJ, Girerd PH, Parikh HI et al. (2019). The vaginal microbiome and preterm birth. Nat. Med. 25: 1012-1021. https://doi.org/10.1038/s41591-019-0450-2; PMid:31142849 PMCid:PMC6750801

14. Han C, Wu V, Fan A et al. (2015). Diagnostic and therapentic advacements for aerobic vaginitis. arch. Gynecol obstet. 29(2): 251-257. https://doi.org/10.1007/s00404-014-3525-9; PMid:25367602

15. Heczko PB et al. (2015). Supplementation of standard antibiotic therapy with oral probiotics for bacterial and aerobic vaginitis: a randomised, double-blind, placebo-controlled trial. BMC Women's Health. 15: 115. https://doi.org/10.1186/s12905-015-0246-6; PMid:26635090 PMCid:PMC4669640

16. Isaevska E, Popovic M, Pizzi C, Fiano V, Rusconi F, Merletti F et al. (2020, Aug). Maternal antibiotic use and vaginal infections in the third trimester of pregnancy and the risk of obesity in preschool children. Pediatr Obes. 15(8): e12632. https://doi.org/10.1111/ijpo.12632; PMid:32174046 PMCid:PMC7507215

17. Ivanova SA, Yakovleva OO. (2015). Diahnostyka zmishanykh infektsii henitalnoho traktu zhinok fertylnoho viku. Liudyna ta liky. Mizhnarodnyi konhres. tezy dopovidei, Kyiv: 18.

18. Kira EF, Korshakova NYu. (2018). Оpen randomized placebo-controlled study of the effectiveness and safety of monotherapy of bacterial vaginosis by vaginal application of lactic acid. Akusherstvo i Ginekologiia. 5: 96-100. https://doi.org/10.18565/aig.2018.5.96-101

19. Konkov DG. (2020). The features of clinical applying of probiotics in obstetric practice. Health of woman. 3(149): 42-47. https://doi.org/10.15574/HW.2020.149.42

20. Konkov DH, Adamchuk NV, Klyvak VV. (2020). Osoblyvosti kompleksnoi terapii bakterialnoho vahinozu u vahitnykh iz porushenniam zatulnoi funktsii 65 shyiky matky. Reproduktyvna endokrynolohiia. 4(54): 59-65. https://doi.org/10.18370/2309-4117.2020.54.55-62

21. Konkov DG, Zhurauleu AY, Honcharenko OM, Lobastova TV, Shevchuk TV. (2022). The clinical assessment of the cervical perforated pessary for the prevention of preterm labor in women with prior preterm births. Wiad Lek. 75; 1; part 2:191-196. https://doi.org/10.36740/WLek202201208; PMid:35182121

22. Lamont RF, Møller Luef B, Stener Jørgensen J. (2020, Feb 25). Childhood inflammatory and metabolic disease following exposure to antibiotics in pregnancy, antenatally, intrapartum and neonatally. F1000Res. 9: F1000 Faculty Rev-144. https://doi.org/10.12688/f1000research.19954.1; PMid:32148773 PMCid:PMC7043129

23. MacIntyre DA, Chandiramani M, Lee YS, Kindinger L, Smith A, Angelopoulos N et al. (2015). The vaginal microbiome during pregnancy and the postpartum period in a european population. Sci. Rep. 5: 8988. https://doi.org/10.1038/srep08988; PMid:25758319 PMCid:PMC4355684

24. Martyshyn O. (2019). Ne vsi probiotyky diiut: yikh efektyvnist i bezpeka u dzerkali dokazovoi medytsyny. Ukrainskyi medychnyi chasopys. 1: 5-7.

25. Mortaki D, Gkegkes ID, Psomiadou V, Blontzos N, Prodromidou A et al. (2020, Sep 3). Vaginal microbiota and human papillomavirus: a systematic review. J Turk Ger Gynecol Assoc. 21(3): 193-200. Epub 2019 Sep 30. https://doi.org/10.4274/jtgga.galenos.2019.2019.0051; PMid:31564082 PMCid:PMC7495129

26. MOZ Ukrainy. (2022). Pro zatverdzhennia Standartiv medychnoi dopomohy «Anomalni vahinalni vydilennia». Nakaz MOZ Ukrainy vid 15.12.2022 No. 2264.

27. Nordqvist M, Jacobsson B, Brantsæter A-L et al. (2018). Timing of probiotic milk consumption during pregnancy and effects on the incidence of preeclampsia and preterm delivery: a prospective observational cohort study in Norway. BMJ Open. 8: e018021. https://doi.org/10.1136/bmjopen-2017-018021; PMid:29362253 PMCid:PMC5780685

28. Paul H, Bomhof M, Vogel H et al. (2016). Diet-induced changes in maternal gut microbiota and metabolomic profiles influence programming of offspring obesity risk in rats. Sci Rep. 6: 20683. https://doi.org/10.1038/srep20683; PMid:26868870 PMCid:PMC4751613

29. Peebles K, Velloza J, Balkus JE, McClelland RS, Barnabas RV. (2019, May). High Global Burden and Costs of Bacterial Vaginosis: A Systematic Review and Meta-Analysis. Sex. Transm. Dis. 46; 5: 304-311. https://doi.org/10.1097/OLQ.0000000000000972; PMid:30624309

30. Polese B, Gridelet V, Araklioti E et al. (2014). The Endocrine Milieu and CD4 T-Lymphocyte Polarization during Pregnancy. Front Endocrinol. 5: 106. https://doi.org/10.3389/fendo.2014.00106; PMid:25071722 PMCid:PMC4083450

31. Prilutckaya AB, Kutch VN, Lyanenko LA, Alekseenko NV. (2016). Current trends in the treatment of bacterial vaginosis Health of woman. 5(111): 65-66.

32. Romero R, Hassan SS, Gajer P, Tarca AL, Fadrosh DW, Nikita L et al. (2014). The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women. Microbiome. 2: 4. https://doi.org/10.1186/2049-2618-2-4; PMid:24484853 PMCid:PMC3916806

33. Sherrard J, Wilson J, Donders G et al. (2018). 2018 European (IUSTI/WHO) International Union against sexually transmitted infections (IUSTI) World Health Organisation (WHO) guideline on the management of vaginal discharge. Int J STD AIDS. 29(13): 1258-1272. Epub 2018 Jul 27. https://doi.org/10.1177/0956462418785451; PMid:30049258

34. Shvets OV. (2020). Synbiotychnyi vplyv z metoiu korektsii ta funkii kyshkovoi mikroflory. Suchasna hastroenterolohyia. 2(112): 60-64.

35. Shyrobokov VP. ta insh. (2011). Medychna mikrobiolohiia, virusolohiia ta imunolohiia. Za red. Shyrobokova V.P. Vinnytsia: Nova knyha: 951.

36. Stepanov YuM. (2015). Probyotyky: dokazatelnaia medytsyna hovoryt… Zdorovia Ukrainy. 4: 27.

37. Stout MJ, Zhou Y, Wylie KM, Tarr PI, Macones GA, Tuuli MG. (2017). Early pregnancy vaginal microbiome trends and preterm birth. Am. J. Obstet. Gynecol. 217: e351-e356. https://doi.org/10.1016/j.ajog.2017.05.030; PMid:28549981 PMCid:PMC5581228

38. Tkach SM. (2020). Dvunapravlennыe vzaymodeistvyia kyshechnoho mykrobyoma y lekarstvennыkh sredstv. Suchasna hastroenterolohiia. 5(115): 79-88. https://doi.org/10.30978/MG-2020-5-79

39. Umanets TR. (2017). Imunomoduliuiuchi efekty probiotykiv. Ukrainskyi medychnyi chasopys. 2: 77-81.

40. USPSTF. (2020). Screening for Bacterial Vaginosis in Pregnant Persons to Prevent Preterm Delivery. Clinician Summary of USPSTF Recommendation, Apr. Int. J. STD. AIDS. 29(13): 1258-1272. doi: 10.1177/0956462418785451. URL: www.umj.com.ua/uk/publikatsia-198461-bakterialnij-vaginoz-suchasnij-stan-problemi-ta-oglyad-ostannih-mizhnarodnih-gajdlajniv.

41. Vedmedovska N, Rezeberga D, Donder GGG. (2015). Is abnormal vaginal microflora a risk factor for intrauterine fetal growth restriction? Asian Pac. J. Reprod. 4: 313-316. https://doi.org/10.1016/j.apjr.2015.07.010

42. Yang S, Li W, Challis JR et al. (2014). Probiotic Lactobacillus rhamnosus GR-1 supernatant prevents lipopolysaccharide-induced preterm birth and reduces inflammation in pregnant CD-1 mice. Am J Obstet Gynecol. 211: 44.e1-44.e12. https://doi.org/10.1016/j.ajog.2014.01.029; PMid:24486224