HEALTH OF WOMAN. 2020.1(147): 42–51; doi 10.15574/HW.2020.147.42
Z.M. Dubossarska, Yu.O. Dubossarska, Ye.O. Puzii
SІ «Dnipropetrovsk medical Academy Ministry of health of Ukraine»

The problem of premature rupture of membranes (PROM) is unfortunately still relevant in modern obstetrics and perinatology, especially in preterm pregnancy, and leads to 20% of all cases of perinatal loss. Among the possible causes, a lot of attention has recently been paid to disorders of connective tissue structure of genetic origin. The article provides an overview of current medical literature on the causes and diagnosis of PROM. Preliminary own data on the positive effect of the advanced algorithm for detecting undifferentiated connective tissue dysplasia (UCTD) on obstetric and perinatal outcomes are also given.
The objective: to clarify the causes of PROM, the role of the severity of connective tissue dysplasia to predict risk factors for preterm birth, especially when combined in pregnant women with anemia.
Materials and methods. A total of 60 pregnant women with IDF were examined. During the survey, laboratory and instrumental methods were used.
Results. Quality of life in women with NDTT had an inverse mean relationship between the patients’ well-being and the number of PST phenotypic manifestations (r = 0.653; p> 94%). In addition, a high constitutionally determined level of personal anxiety was established. Quality of life depends on the number and severity of phenotypic abnormalities, ie the more signs of connective tissue dysplasia (joint hypermobility, scoliosis, nephroptosis, increased bleeding, myopia, pronounced varicose veins, etc.), the lower this indicator. As pregnancy progressed, worsening of health and decrease in quality of life in patients with NDST was observed.
Conclusion. The advanced algorithm has demonstrated the positive effects in pregnant women with undifferentiated connective tissue dysplasia on obstetric and perinatal delivery, and the findings suggest that it is practiced in health care.
Key words: premature rupture of membranes, preterm pregnancy, undifferentiated connective tissue dysplasia.

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