PERINATOLOGIYA I PEDIATRIYA.2014.2(58):71-74;doi10.15574/PP.2014.58.71 
 

Value of factor index of growth of hepatocyte in diagnostics progressing chronic viral children hepatitis 
 

Denysova M. F., Musyka N. M., Chernega N. B., Byba N. B.

State Institution «Institute of pediatrics, obstetrics, gynaecology of Ukraine», Kyiv, Ukraine 
 

Purpose – on the basis of hepatocytes index factor of growth definition of concentration in blood serum of children, that are chronic viral hepatitis B C- infected, to give a characteristic to regenerative ability of a liver, to identify the group of risk of unfavorable course of a disease. 
 

Patients and methods. The identification of concentration of hepatocytes factor of growth index in blood serum were served by the means of enzyme immunoassay in 82 children, that are chronic viral hepatitis B C – infected and that are healthy. 
 

Results. It is shown, that chronic viral hepatitis infected have advanced concentration of hepatocytes factor of growth index in blood serum in comparison with healthy children, significant advancing in the presence of active inflammatory process, back cross correlate with the duration of a disease. 
 

Conclusion. Progredient course of chronic viral hepatitis in early age dictates the necessity to administer methods of control for a process of fibrogenesis in order to prevent complications, improvement of ethiopathogenetic treatment, secondary prophylaxes. Usage of factor index of growth of hepatocyte as a marker of regenerative ability of a liver in dynamic observation for a chronic viral hepatitis B and C course. Method of a survey has an advantage due to noninvasiveness, ability to predict disease recurrence and also an ability to conduct effective treatment analysis. 
 

Key words: chronic viral hepatitis, children, factor of growth of hepatocyte. 
 

REFERENCES

1.Бабак ОЯ, Колесникова ЕВ. 2011. Цироз печени и его осложнения. К: 576.

2. Бабак ОЯ, Колесникова ЕВ, Кравченко ИА. 2009. Сучасна гастроентерологія 2(46):5–17.

3. Губергриц НБ. 2008. Сучасна гастроентерологія 5(43): 79–89.

4. Денисова МФ, Музика НМ. 2012. Современная педиатрия 7(47): 188–185.

5. Драпкина ОМ, Дуболазова ЮВ. 2008. Consilium Medicum 10,2: 18–22.

6. Железнякова ТФ. 2007. Вопросы вирусологии 4: 4–10.

7. Матвеев АВ, Коняева ЕИ, Матвеева НВ. 2011. РЖГГК 21,5: 64–69.

8. Пасечник Ю. 2008. Здоров’я України 21: 72–75.

9. Северов МВ. 2008. Гепатологический форум 1: 2–6.

10. Сторжаков ГИ, Ивкова АН. 2009. Клин перспективы гастроэнтерологии, гепатологии 2: 3–10.

11. Чуелов СБ, Россина АЛ. 2007. Детские инфекции 7: 34–40.

12. Яковенко ЭП, Яковенко АВ, Иванов АД и др. 2011. Фарматека 12: 16.

13. Afdhal NH and Nunes D. 2008. Am. J. Gastroenterol. 99: 1174. Das SK, Vasudevan DM. 2008. 
14. Scand. J. Clin. Lab. Invest. 4(68): 260–269. http://dx.doi.org/10.1080/00365510701668516

15. Mallet V, Serpaggi J. et al. 2008. Am. Intern. Med. 149(6): 399–403. http://dx.doi.org/10.7326/0003-4819-149-6-200809160-00006

16. Okaraki G, Ninomiya Y, Friedman S, Tanilowa K. 2009. Orlando: Academic Press: 15–36, 155–169.

17. Zhao L, Burt AD. 2007. J. Mol. Hist. 38: 53–64. http://dx.doi.org/10.1007/s10735-007-9078-5