SOVREMENNAYA PEDIATRIYA.2017.1(81):117-120; doi 10.15574/SP.2017.81.117

Shevchuk D. V.
Zhytomyr regional children's clinical hospital, Ukraine
Zhytomyr state University named after Ivan Franko, Ukraine
Shupyk National Medical Academy of Postgraduate Education, Kiev, Ukraine

Interstitial cells of Cajal (ICC) were first discovered in 1893 in the wall of the intestine, and only after almost 100 years of interest in the ICC recovered. In addition, modern technologies have allowed to identify similar cells in other organs, in particular those that contain the muscle fibers and, accordingly, shall be subject to reduction. So, ICC was detected in the urinary tract, fallopian tubes, the seminiferous tubules etc. Further study of the functions of the ICC has established a link between human peripheral information of the bladder (neuromuscular dysfunction of bladder) and the concentration of ICC. Thus, the measurement of ICC in the bladder wall when it is dysfunction may affect the tactics of patient management in the future.

Key words: interstitial cells of Cajal, neuromuscular dysfunction of bladder.

References

1. Hrusha MM. 2016. Novi aspekty mizhklitynnoi vzaiemodii v stintsi kyshechnyku. Visnyk problem biolohii i medytsyny. 1; 1(126): 17—21.

2. Mishalov VG, Leschishin IM, Ohotskaya OI et al. 2015. Neyrogliopatiya kishechnika kak prichina funktsionalnogo zapora. Khirurhiia Ukrainy. 4: 20—27.

3. Tsymbaliuk OV, Martyniuk VS. 2012. Vplyv mahnitnoho polia nadnyzkoi chastoty na spontannu skorotlyvu aktyvnist intestynalnykh hladenkykh miaziv. Visnyk Cherkaskoho un-tu. 2(215): 128—133.

4. Ahmed HF, Helal O, Abdel-Wahab H. 2006. Histological And Immunohistochemical Study On Interstitial Cells Of Cajal In Normal Human Fallopian Tube And In Cases Of Ectopic Pregnancy. The Egyptian Journal Of Histology. 29; I: 85—102.

5. Akhtar T, Alladi A, Siddappa OS. 2012. Megacystis-microcolon-intestinal hypoperistalsis syndrome associated with prune belly syndrome: a case report. J Neonat Surg. 1: 26.

6. Arena S, Fazzari C, Arena F et al. 2007. Altered “active” antireflux mechanism in primary vesico-ureteric reflux: a morphological and manometric study. BJUI. 100; Is 2: 407—412. doi 10.1111/j.1464-410X.2007.06921.x.

7. Juszczak K, Maciukiewicz P, Drewa T, Thor PJ. 2013. Cajal-like interstitial cells as a novel target in detrusor overactivity treatment: true or myth? Cent European J Urol. 66 (4): 413—417. doi 10.5173/ceju.2013.04.art5 https://doi.org/10.5173/ceju.2013.04.art5 PMCID: PMC3992455.

8. Arena F, Nicotina PA, Arena S et al. 2007. C-kit positive interstitial cells of Cajal network in primary obstructive megaureter. Minerva Pediatrica. 59 (1): 7—11. PMID:17301719. PMid:17301719.

9. Metzger R, Rolle U, Fiegel HC et al. 2008. C-kit receptor in the human vas deferens: distinction of mast cells, interstitial cells and interepithelial cells. Reproduction. 135: 377—384. https://doi.org/10.1530/REP-07-0346.

10. Gupta A, Bajpai M, Mallick S et al. 2014. Cloacal Exstrophy: A Histomorphological Analysis of the Bladder Plate and Correlation with Bladder Dynamics. Journal of Progress in Paediatric Urology. 17; Is 1: 33—36.

11. Balikci O, Turunc T, Bal N et al. 2015. Comparison of Cajal-like cells in pelvis and proximal ureter of kidney with and without hydronephrosis. Int Braz J Urol. 41; 6: 1178—1184. http://dx.doi.org/10.1590/S167755538. IBJU.2014.0427.

12. Davidson RA, McCloskey KD. 2005. Morphology and localization of interstitial cells in the guinea pig bladder: structural relationships with smooth muscle and neurons. The Journal of Urology. 173; Is 4: 1385—1390.

13. He C-L, Burgart L, Wang L et al. 2000. Decreased interstitial cell of Cajal volume in patients with slow-transit constipation. Gastroenterology. 118(1): 14—21. http://dx.doi.org/10.1016/S001655085(00)7040954.

14. Tan Y-Y, Ji Z-L, Zhao G et al. 2014. Decreased SCF/c-kit signaling pathway contributes to loss of interstitial cells of Cajal in gallstone disease. Int J Clin Exp Med. 7(11): 4099—4106. PMid:25550919 PMCid:PMC4276177

15. Piaseczna-Piotrowska AM, Dzieniecka M, Kulig A et al. 2011. Different distribution of c-kit positive interstitial cells of Cajal-like in children's urinary bladders Folia. Histochemica et Cytobiologica. 49; 3: 431—435. https://doi.org/10.5603/FHC.2011.0061.

16. Tekin A, Karakus OZ, Hakguder G et al. 2016. Distribution of interstitial cells of Cajal in the bladders of fetal rats with retinoic acid induced myelomeningocele. Turk J Urol. 42(3): 285—289. https://doi.org/10.5152/tud.2016.98474.

17. Piaseczna-Piotrowska A, Dzieniecka M, Samolewicz E et al. 2013. Distribution of interstitial cells of Cajal in the neurogenic urinary bladder of children with myelomeningocele. Advances in Medical Sciences. 58; Is 2: 388—393.

18. Kubota Y, Biers SM, Kohri K, Brading AF. 2006. Effects of imatinib mesylate (Glivec) as a c-kit tyrosine kinase inhibitor in the guinea-pig urinary bladder. Neurourology and Urodynamics. 25(3): 205—210. PMID: 16425211. https://doi.org/10.1002/nau.20085.

19. Gray SM, McGeown JG, McMurray G, McCloskey KD. 2013. Functional Innervation of Guinea-Pig Bladder Interstitial Cells of Cajal Subtypes: Neurogenic Stimulation Evokes In Situ Calcium Transients. PLoS ONE. 8(1): 53423. https://doi.org/10.1371/journal.pone.0053423.

20. Hashitani H. 2006. Interaction between interstitial cells and smooth muscles in the lower urinary tract and penis. J Physiol. 576: 707—714. https://doi.org/10.1113/jphysiol.2006.116632

21. Shafik A, El-Sibai O, Shafik AA, Shafik I. 2004. Identification of interstitial cells of Cajal in human urinary bladder: Concept of vesical pacemaker. Urology. 64; Is 4: 809—813.

22. Piaseczna-Piotrowska A, Rolle U, Solari V, Puri P. 2004. Interstitial cells of Cajal in the human normal urinary bladder and in the bladder of patients with megacystis-microcolon intestinal hypoperistalsis syndrome. BJU Int. 94 (1): 143—6. https://doi.org/10.1111/j.1464-410X.2004.04914.x; PMid:15217450

23. Wang H, Zhang Y, Liu W et al. 2009. Interstitial cells of Cajal reduce in number in recto-sigmoid Hirschsprung's disease and total colonic aganglionosis. Neuroscience Letters. 451: 208—211. https://doi.org/10.1016/j.neulet.2009.01.015.

24. Klemm MF, Exintaris B, Lang RJ. 1999. Identification of the cells underlying pacemaker activity in the guinea-pig upper urinary tract. J Physiol. 519 (3): 867—884. doi 10.1111/5j.1469-7793.1999.0867n.x.

25. Mehrazma M, Tanzifi P, Rakhshani N. 2014. Changes in structure, interstitial Cajal-like cells and apoptosis of smooth muscle cells in congenital ureteropelvic junction obstruction. Pathology. 46; Suppl 2: 134. https://doi.org/10.1097/01.PAT.0000454556.77877.27

26. Mostafa RM, Moustafa YM, Hamdy H. 2010. Interstitial cells of Cajal, the Maestro in health and disease. World J Gastroenterol. 16 (26): 3239—3248. doi 10.3748/5WJG.v16.i26.3239.

27. Kenny SE, Connell G, Woodward MN et al. 1999. Ontogeny of Interstitial Cells of Cajal in the Human Intestine. Journal of pediatric Surgery. 34 (8): 1241—1247. https://doi.org/10.1016/S0022-3468(99)90160-4

28. McHale NG, Hollywood MA, Sergeant GP et al. 2006. Organization and function of ICC in the urinary tract. J Physiol. 576 (3): 689—694. https://doi.org/10.1113/jphysiol.2006.116657; PMid:16916908 PMCid:PMC1890397

29. Arena S, Iacona R, Impellizzeri P et al. 2016. Physiopathology of vesico5ureteral reflux. Italian Journal of Pediatrics. 42: 103. doi 10.1186/s13052-016-03165x.

30. Kubota Y, Kojima Y, Shibata Y et al. 2011. Role of KIT-Positive Interstitial Cells of Cajal in the Urinary Bladder and Possible Therapeutic Target for Overactive Bladder. Advances in Urology. 2011. Article ID 816342. 7. https://doi.org/10.1155/2011/816342.

31. Solari V, Piaseczna-Piotrowska A, Puri P. 2003. Altered Expression of Interstitial Cells of Cajal in Congenital Ureteropelvic Junction Obstruction. The Journal of Urology. 170 (6/1): 2420—2422.

32. Biers SM, Reynard JM, Doore T, Brading AF. 2006. The functional effects of a c-kit tyrosine inhibitor on guinea-pig and human detrusor. BJU International. 97 (3): 612—616. PMID: 16469036. https://doi.org/10.1111/j.1464-410X.2005.05988.x.

33. Yang X, Zhang Y, Hu J. 2009. The expression of Cajal cells at the obstruction site of congenital pelviureteric junction obstruction and quantitative image analysis. Journal of Pediatric Surgery. 44: 2339—2342. https://doi.org/10.1016/j.jpedsurg.2009.07.061.