Modern Pediatrics.Ukraine.2019.8(104):52-56; doi 10.15574/SP.2019.104.52
Klymenko Kh., Nadraga A.
Danylo Halytsky Lviv National Medical University, Ukraine

For citation: Klymenko Kh, Nadraga A. (2019). Tonsilitis syndrome in children with acute Epstein-Barr viral infection. Modern Pediatrics. Ukraine. 8(104): 52-56. doi 10.15574/SP.2019.104.52
Article received: Jul 29, 2019. Accepted for publication: Dec 07, 2019.

Objective. To study the clinical particularities of infectious mononucleosis (ІМ) in the children caused by Epstein–Barr virus with tonsilites and with colonized pathogenic microorganisms mucous membranes of the tonsils.
Materials and methods. The medical records of 67 inpatient children up to 18 years of age who were treated with a diagnosis IM. Children were divided into 2 groups: with pathogenic microorganisms (group 1) and patients with negative results of bacteriological screening (group 2).
Results. A more severe course of the disease was observed in children with ІМ with colonized mucous membranes of the tonsils by pathogenic microorganisms. According to the results of a laboratory blood test, C-reactive protein, Antistrepolisin-O, Alaninaminotransferase levels were higher in the patients of group 1.
Conclusions. More severity of the disease was in the group of patients with acute tonsillitis of bacterial etiology. Factors associated with colonization of the tonsils by the pathogens are female sex, time of year, age, hepatomegaly, hyperthermia, and high levels of mononuclear cells in the blood.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of Danylo Halytsky Lviv National Medical University. The informed consent of the patient was obtained for conducting the studies.
No conflict of interest was declared by the authors.
Key words: children, Epstein-Barr virus, infectious mononucleosis, tonsillitis.

REFERENCES

1. Deo PN, Deshmukh R. (2019). Oral microbiome: Unveiling the fundamentals. Journal of oral and maxillofacial pathology. JOMFP.23(1): 122–128. doi: 10.4103/jomfp.JOMFP_304_18

2. Fabrega-Ferrer M, Zhou D et al. (2019). Atomic structure of the Epstein–Barr virus portal. Nat Commun. 10: 3891. https://doi.org/10.1038/s41467-019-11706-8; PMid:31467275 PMCid:PMC6715670

3. Gomez A, Nelson KE. (2017). The Oral Microbiome of Children: Development, Disease, and Implications Beyond Oral Health. Microbial ecology.73(2): 492—503. https://doi.org/10.1007/s00248-016-0854-1; PMid:27628595 PMCid:PMC5274568

4. Greydanus D, Merrick J. (2019). Infectious mononucleosis: be aware of its lethality! International Journal of Adolescent Medicine and Health. 31(1). https://doi.org/10.1515/ijamh-2018-0284

5. Klein R. (2019). Infections of the Oropharynx Matthew. Emerg Med Clin N Am. 37 (2019): 69—80. https://doi.org/10.1016/j.emc.2018.09.002; PMid:30454781

6. Rostgaard K, Balfour HH Jr, Jarrett R, Erikstrup C et al. (2019). Primary Epstein–Barr virus infection with and without infectious mononucleosis. PLoS ONE 14(12): e0226436. https://doi.org/10.1371/journal.pone.0226436; PMid:31846480 PMCid:PMC6917282