SOVREMENNAYA PEDIATRIYA.2016.8(80):26-29; doi 10.15574/SP.2016.80.26 

The role of TLR2 in the implementation of congenital and acquired pneumonia in newborn infants 

Yablon O. S., Reminna I. I.

Vinnitsa National Medical University M.I. Pirogov, Ukraine

Objective: To investigate the role of Toll2-like receptors in the implementation of congenital and acquired pneumonia in newborn infants.

Materials and methods. Clinical and paraclinical studies of 69 term infants with pneumonia. They completed clinical and paraclinical survey methods (C-reactive protein, Toll Like Receptor 2 content in the blood serum, X-ray examination of the chest).

Results and discussion. It is found that the content of TLR2 in children who had respiratory disorders clinic during the first 48 hours of life was significantly lower than in children, which clinic was appeared after 48 hours. Analyzing the level of TLR2 in children, depending on the need for an invasive respiratory support, it was concluded that there is no significant difference between the indicators of TLR2 for newborns in need and indicators of those that did without invasive respiratory support. It was also determined the dependence of TLR2 indicator of CRP levels — the higher the score, the lower the level of TLR2 (children both groups of study). Evaluation index TLR2, depending on the localization of the inflammatory process in the lungs, showed that with the proliferation of infiltrative changes in lung, in children II group there was an increase in the level of TLR2 and in children I group — reduction.

Conclusions. TLR2 content in the blood serum of newborns that have clinical signs of respiratory distress and intoxication in neonatal period, significantly exceeded the indicators of the control group. However, TLR2 index in infants with congenital pneumonia was significantly lower than in children with acquired pneumonia. Was established the inverse relation between the content TLR2 from severity of inflammation in the lung, in particular from radiographic image of prevalence infiltrative changes and parameter values of serum CRP.

Key words: neonatal pneumonia, Toll2-like receptors, C-reactive protein, X-ray examination of the chest.

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