• The role of molecular-genetic counseling in detection of benign and malignant pathology of female reproductive system organs
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The role of molecular-genetic counseling in detection of benign and malignant pathology of female reproductive system organs

HEALTH OF WOMAN. 2016.6(112):153–157 
 

The role of molecular-genetic counseling in detection of benign and malignant pathology of female reproductive system organs 
 

Palyichuk O. V.

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of National Academy of Sciences of Ukraine, Kyiv

CE «Cherkassy Regional Oncologic Dispensary» of Cherkassy Regional Council

Medical center «Adromeda-plus» Ltd., Cherkassy 
 

The objective: introducing the questionnaire method to identify families with aggregation of tumor pathology in the population of Cherkassy region (in patients with benign and malignant diseases of the female reproductive system (OZHRS) with a history of cancer family histo; ry), an in;depth clinical examination of women of those families, and bringing the feasibility of health genetic counseling for the diagnosis of tumor pathology and the formation of high;risk groups of precancer and cancer OZHRS.


Patients and methods. Medical and genetic counseling 1103 (100%) patients and the introduction of their questionnaire method during the reception at the gynecologist;oncologist 343 (31.1%) of patients with cancer of the female reproductive system were conducted (ROZHRS) and a gynecologist – 760 (86.9%) in healthy women who applied for the purpose of baseline medical examination, to identify families with aggregation of tumor pathology.


Results. Analysis of clinical and genealogical data for women from such families found that the association of cancer in these families cor; responds to a cancer family syndrome (Lynch II syndrome) or family cancer. A comprehensive clinical examination of probands revealed malignant and benign pathology of breast, cervical and endometrial, ovarian and digestive tract.


Conclusion. The results are the testimony of the effectiveness of the introduction of profiles, questionnaires in medical practice for clinical and genealogical analysis and evaluation of family onkoanamneza to identify a group of inherited risk ROZHRS, as well as for the timely diagnosis of precancerous and tumor pathology processes in family members s aggregation of malignant tumors.


Key words: cancer of female reproductive system organs, hereditary cancer syndrome, medical-generic counseling of family trees.


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