PERINATOLOGIYA I PEDIATRIYA.2015.4(64):108-110; doi 10.15574/PP.2015.64.108 
 

The importance of adipokines and insulin resistance in development of arterial hypertension at children with overweight and obesity 
 

Matraguna N. G., Bikir-Thoryak L. I., Kojokari S. V., Yerohina O. V., Babiy K. V.

Cardiology institute, scientific laboratory in paediatric cardiology, The Republic of Moldova 
 

Purpose — defining the level of the leptin, adiponectin and insulin as important risk factors in the development of arterial hypertension at children with overweight or obesity. 
 

Patients and methods. The investigation included 100 children suffering from arterial hypertension with overweight or obesity (average age 14.3) and was based on determination of serum leptin and adiponectin as well as insulin. 
 

Results. Most of children in both groups suffered from obesity of mixed type (group I — 70%, group II — 76%). Statistically significant increased level of insulin and leptin was found in both investigated groups as compared to the control one. When investigating serum adiponectin, there was determined low level of this marker in group I (8.00 ng/l) as compared to group II (9.00 ng/l) and control group (10.95 ng/l) with statistically significant difference (p>0.05). 
 

Conclusions. Timely determination of these markers at children with obesity can assist in taking measures to prevent complications in development of this disease. 
 

Key words: children, arterial hypertension, obesity, leptin, adiponectin, insulin. 
 

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