SOVREMENNAYA PEDIATRIYA. 2014.8(64):55–59

The effectiveness of clarithromycin during the acute respiratory diseases in children

Agafonova E. A., Deyev V. V., Moskalenko L. M., Tatyanenko O. V., Titarenko O. V., Kuprinenko N. I., Novikova E. Yu.

State institution «Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine»

Communal institution «Dnipropetrovsk City Clinical Hospital №9» of the Dnipropetrovsk regional council, Levoberezhnaya

Centralized Bacteriological Laboratory

Objective: To analyze the clinical efficacy of clarithromycin during the acute respiratory diseases in children with different levels of resistance to bacterial agents.

Patients and methods. The study of eradication and clinical efficacy of clarithromycin in 128 children with clinical manifestations of acute respiratory infections depending on the frequency of incidence during the year is conducted. The main group consisted of 72 (4 or more incidence of ARI per year), control group (3 or less incidence of ARI per year) — 56 children. Clarithromycin was prescribed by a course of 5 days. Etiological diagnosis and sensitivity of pathogens to clarithromycin were determined by means of a culture examination.

The Results. The etiological factor in the main group significantly more was S. aureus OR = 1,49 (CI = 95%; OR = 1,44-1,52) at the same time in 3.7% of children of the first group was marked methicillin-resistant Staphylococcus aureus. Eradication efficacy of clarithromycin in the main group was slightly lower (93.0%) than in the control group (94.6%). However, indicators of clinical efficacy of clarithromycin were higher in the main group, which was manifested by absolute risk reduction in respect of the late positive dynamics of the disease (ARR = 0,21, p> 0,05) and delayed reduction of the leading clinical syndromes (ARR = 0,39, p <0.05).

Conclusions. Clarithromycin can be effectively used as a basic treatment of bacterial acute respiratory infections in children of all ages, especially in children, who often suffer from respiratory diseases.

Key words: clarithromycin, acute respiratory infections, children.

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