PERINATOLOGIYA I PEDIATRIYA.2015.2(62):12-15;doi10.15574/PP.2015.62.12

The effect of probiotics on the state of placental barrier in pregnant women with chronic pyelonephritis

Demenina N. K., Yeschenko Y. I., Ischenko H. I., Milievskyi O. V.

SI «Institute of Pediatrics, Gynecology and Obstetrics NAMS of Ukraine», Kyiv, Ukraine

Purpose — to study the morphological and morphometric features of placenta in pregnant women with chronic pyelonephritis.

Patients and methods. The study of morphological characteristics of placenta was conducted in the following groups. Group I – 70 placentas from women with chronic pyelonephritis who received treatment according to current recommendations. Ggroup II — 50 placentas from women with chronic pyelonephritis who have additionally undergone restoration of birth canal and intestinal microbiocenosis with probiotic composition of live strains L.plantarum ВКПМ В-5002 and Str. salivarius subsp. thermophilus ВКПМ В-3813 at a ratio of 8:2 and dose of 108–109 CFU/ml before childbirth. Group III (control) — placentas from healthy women with normal pregnancy. To study the morphological features of placentas used organometric, macroscopic, histological methods.

Results. In the group of women with chronic pyelonephritis (group I), multiple histologic and morphometric features of placentas showed 2 degree chronic placental insufficiency with the elements of immaturity according to the type of differentiated intermediate villi and dissociated villi in 60% of cases. In this group the focal changes in decidua as swelling and thickening were found in 36% of placentas. Sometimes deciduas were infiltrated by lymphocytes, plasma cells, segmented neutrophils, so inflammation of decidua was observed. In the group of women with chronic pyelonephritis who additionally received probiotic composition (group II), 40% of placentas had histological and morphological sings of 1–2 degree chronic placental insufficiency. The phenomenon of inflammatory infiltration in decidua and intervillous space was found in 34% of placentas of this group.

Conclusions. We found structural features that indicate the 2 degree chronic placental insufficiency and a high level of inflammatory infiltration of deciduas in placentas from women with chronic pyelonephritis.

Key words: chronic pyelonephritis, pregnancy, placenta.