PERINATOLOGIYA I PEDIATRIYA.2015.3(63):63-65;doi 10.15574/PP.2015.63.63 
 

The containing of 25-hydroxy-calciferol in the blood serum of children with juvenile rheumatoid arthritis 
 

Ludvik T. A.

SI «Institute of Pediatrics, Obstetrics and Gynecology NAMS of Ukraine», Kyiv, Ukraine 
 

Objective: to study the concentration of 25-hydroxy-calciferol in the blood serum of children with various forms of juvenile rheumatoid arthritis according to the degree of disease activity. 
 

Patients and methods. A total of 29 children in the age 2.5–15 years with such pathology were under observation. All patients underwent general clinical examination. For assessment of the activity of the disease, along with clinical criteria were determined the ESR and CRP indexes; containing of proinflammatory cytokine TNF-a and its soluble receptors (TNF-P55, TNF-P75) in the blood serum by the use of enzyme immunoassay using exclusive reagents from David Wallach (Israel, Weizman Institute of Science Rehovot). A level of 25-hydroxy-calciferol was examined with the use of a commercial Vitamin D3 screening kit (Switzerland). The content of calcium in the serum and red blood was examined with the use of biotest kitvia (Lachema-Borno, Czech Republic). Benchmarks were data obtained during the examination of 16 healthy children of the same age as sick children. 
 

Results. It is shown that the content of 25-hydroxy-calciferol in the blood of patients considerably lower than in healthy children. During the systemic form of juvenile rheumatoid arthritis the content of 25-hydroxy-calciferol in the blood are reduced to the levels of observed deficiency of this vitamin in the body. 
 

Conclusions. It is advisable to administrate vitamin D to such patients for normalizing of the level of 25-hydroxy-calciferol in the blood serum in conjunction ith the anti-inflammatory and basic preparations. Such a correction of vitamin D-status of patients with juvenile rheumatoid arthritis will contribute to the effectiveness of treatment, increase the duration of remission and reduce the frequency of exacerbations of articular syndrome and relapse of the disease. 
 

Key words: juvenile rheumatoid arthritis, children, 25-hydroxy-calciferol. 
 

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