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  • The state of uteroplacental hemodynamics in women giving birth for the first time, of different reproductive ages
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The state of uteroplacental hemodynamics in women giving birth for the first time, of different reproductive ages

Ukrainian Journal Health of Woman. 2025. 6(181): 37-43. doi: 10.15574/HW.2025.6(186).3743
Chernov А. V.
Shupyk National Healthcare University of Ukraine, Kyiv

For citation: Chernov АV. (2025). The state of uteroplacental hemodynamics in women giving birth for the first time, of different reproductive ages. Ukrainian Journal Health of Woman. 6(181): 37-43. doi: 10.15574/HW.2025.6(186).3743
Article received: Sep 21, 2025. Accepted for publication: Nov 20, 2025.

Aim – to analyze the state of uteroplacental hemodynamics and hormonal function of the fetoplacental complex in women giving birth for the first time, of different reproductive ages to optimize corrective therapy and promote timely delivery.
Materials and methods.. 174 histories of pregnancy and childbirth of women giving birth for the first time were analyzed, which were divided into groups according to age: I group – 85 pregnant women aged 20-29 years, II group – 89 pregnant women aged 30-40 years. The indicators of blood flow parameters in the "mother-placenta-fetus" system, the content of hormones: progesterone, placental lactogen, estriol were studied. Statistical processing of the research results was carried out using standard programs "Microsoft Excel 7.0" and "Statistica 8.0".
Results. Resistance indicators in the uteroplacental and fetal-placental blood flow links in group II showed a significant decrease in blood flow as pregnancy progresses, in the umbilical artery from 33 weeks of gestation (p<0.001). At 18-27 weeks in group II pregnant women, blood flow disorders in the mother-placenta-fetus system were detected in 14 (15.7%) cases, and by 37 weeks their number increased significantly and amounted to 22 (24.7%) cases. In every fifth woman in group II in the II and III trimesters, the progesterone level was 2 times lower than normal. A significant decrease in estriol concentrations was observed in pregnant women in group II: in the II trimester in every fourth woman – 23 (25.8%) cases, and in the III trimester in almost 2/3 cases in 53 (59.6%) pregnant women. Similar patterns were found when studying the content of placental lactogen.
Conclusions. Dynamic monitoring of pregnant women over 30 years old who are giving birth for the first time, with mandatory ultrasound dopplerometry, allows for timely detection of circulatory disorders in the mother-placenta-fetus system and early signs of placental insufficiency and timely correction of these disorders and timely delivery.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the institution mentioned in the paper. The informed consent of the patients was obtained for conducting the studies.
No conflict of interests was declared by the author.
Keywords: pregnant women giving birth for the first time, reproductive age, ultrasound examination, dopplerometry, uteroplacental hemodynamics, hormonal function of the fetoplacental complex, placental dysfunction.
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