- State of fеtus in pregnant with the threat of premature births and thrombophilic disorders after treatment of coagulation disorders
State of fеtus in pregnant with the threat of premature births and thrombophilic disorders after treatment of coagulation disorders
HEALTH OF WOMAN. 2016.3(109):36–39; doi 10.15574/HW.2016.109.36
State of fеtus in pregnant with the threat of premature births and thrombophilic disorders after treatment of coagulation disorders
Zhuk S. I., Us I. V.
National Medical Academy of Postgraduate Education P. L. Shupyk, Kiev
Perinatal center, Kiev
The objective: to study the state of fetus in women with the threat of premature births of trombophilic genesis after treatment of coagulation disorders.
Patients and methods. Treatment is conducted 66 women with the threat of premature births and thrombophilic disorders. Correction of coagulation disorders is developed with the use of geparinoid sulodeksid, low-molecular heparin of bemiparina sodium, antiagregant aspirin, folacin, vitamins of B and omega-3 fat acids dependency upon reason and character of expressed of the trombophilic state. For all pregnant studied the state of the system of hemostazis and state of fetus before and after treatment.
Results. Use of the indicated therapy at 36 pregnant simultaneously with the standard chart of treatment of threat of premature births resulted in normalization of indexes of the system of hemostasis and improvement of the state of fetus: the amount of pathological cardiotocographic changes diminished, the general point of estimation of biophysical profile of fetus increased, dopplerometria research of blood stream in an umbilical cord specified on the decline of indexes of vascular resistance, that testified to indemnification of blood stream.
Conclusion. Correction of coagulation allowed to improve of the state of fetus in women with the threat of premature births of trombophilic genesis.
Key words: thrombophilic disorders, threat of premature births, system of gemostazis, correction of coagulation disorders, fetus, dopplerometria.
REFERENCES
1. Dolgushina VF, Vereina NK. 2013. Study of frequency of exposure of genetic polymorphism associated with a thrombophilia. Obstetrics and gynaecology 3:27-31.
2. Zhuk SI, Bila VV, Us IV, Atamanchuk ІМ. 2013. Planning, prenatal care and delivery in woman with trombophilic disorders of various origins. Womanꞌs health 10:62-70.
3. Zhuk SI, Us IV, Atamanchuk ІМ. 2015. Clinical and laboratory characteristics of pregnant women with threat of premature delivery associated with thrombophilic state. Biomedical and biosocial anthropology 25:141-145.
4. Zainulina MS, Arutyunyan AV, Kornyushina EA, Pustugina AV, Mirashvili MI. 2010. Modern diagnostics, medicamental therapy and prophylaxis of obstetric complications for women with a thrombophilia. Magazine of obstetrics and woman illnesses 4:90-98.
5. Kornyushina EA, Zainulina MS. 2008. Violations in the system of hemostasis, methods of their correction and ends of pregnancy for patients with unmaturing and thrombophilia. Magazine of obstetrics and woman illnesses 4:89-95.
6. Kulakov VI, Serov VN, Sidelnikova VM. 2002. Premature births are tactics of conduct taking into account the term of hestation. Magazine of obstetrics and woman illnesses 2:13-17.
7. Makatsaria AD, Bitsadze VO, Genievskaya MG. 2003. Antiphosphotide syndrome is in obstetric practice. M, Russo:344.
8. Nesterova EA, Putilova NV. 2014. A role of paternal-fetus thrombophilia is in forming of heavy forms of placenta insufficiency. Obstetrics and gynaecology 12:5-9.
9. Pestrikova TY, Yurasova EA, Butko TM. 2008. Perinatal losses are backlogs of decline. M.: Littera:199.
10. Turan O, Turan S, Funai E et al. 2007. A novel method to identify women at risk for impending preterm birth. Obstet. Gynecol. 109:855-862. http://dx.doi.org/10.1097/01.AOG.0000258282.47919.41; PMid:17400846
11. Jauniaux E, Farquharson RG, Christiansen OB et al. 2006. Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage. Hum. Reprod. 21:2216-2222. http://dx.doi.org/10.1093/humrep/del150; PMid:16707507