Ukrainian Journal of Perinatology and Pediatrics. 2020. 1(81): 59-63; doi 10.15574/PP.2020.81.59
Limanskaya A. Yu., Nerosnak Yu. P.
SI «Institute of Pediatrics, Obstetrics and Gynecology named of academician O.M. Lukyanova NAMS of Ukraine», Kyiv

For citation: Limanskaya AYu, Nerosnak YuP. (2020). Short intergenetic interval as a prerequisite for the occurrence of iron deficiency anemia in pregnant women. Ukrainian Journal of Perinatology and Pediatrics. 1(81): 59–63. doi 10.15574/PP.2020.81.59
Article received: Nov 28, 2019. Accepted for publication: Mar 11, 2020.

Purpose — to determine the effectiveness of correction of iron deficiency and treatment of iron deficiency anemia (IDA) in pregnant women with a short intergenetic interval.
Patients and methods. The study included the treatment of 19 pregnant women with mild IDA with a short intergenetic interval. The pregnant women received the oral Sorbifer Durules from 20 weeks of pregnancy 1 tablet twice a day (4 mg/kg/day). The treatment efficacy was evaluated by the reticulocyte count on days 8–12 of treatment, by the hemoglobin concentration at 3–4 weeks of treatment and in terms of ferritin for the third month of antianemic treatment.
Results. After treatment of pregnant women with a short intergenetic interval and mild iron deficiency anemia, reticulocytic crisis was observed on the 8–12th day to 0.6±0.01%, which and indicates the effectiveness of treatment. Increasing the hemoglobin more than 20 g/l was observed after 3–4 weeks, the restoration of iron deficiency (by ferritin level) — after 3 months of treatment. There were no side effects in 16 (84.2%) in women, restoration of daily activity in 100% of pregnant women. In the vast majority of pregnant women, a positive result occurs after 10 days of treatment, which is confirmed by laboratory data and indicates the high effectiveness of the drug.
Conclusions. Due to the fact that iron deficiency states of a pregnant woman lead to a high incidence of obstetric and perinatal complications, the issue of preventing iron deficiency and treating iron deficiency anemia during pregnancy is an urgent issue. Sorbifer Durules has a proven safety profile and minimal side effects and recommended for the treatment of iron deficiency anemia and the prevention of iron deficiency in pregnant women.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of this Institute. The informed consent of the patient was obtained for conducting the studies.
No conflict of interest were declared by the authors.
Key words: pregnancy, short intergenetic interval, anemia, Sorbifer Durules.

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