PERINATOLOGIYA I PEDIATRIYA.2014.2(58):34-36; doi 10.15574/PP.2014.58.34  
 

Screening among healthy children and children with allergic diseases on the detection of vitamin D-deficiency 
 

Tyazhka A. V., Selska Z. V.

Bogomolets national medical university, Kyiv, Ukraine 
 

Purpose — conduct screening in children with allergic diseases (asthma, atopic dermatitis and allergic rhinitis) and in children who do not have allergic reactions to detect vitamin D-deficiency. 
 

Materials and methods. We examined 53 pediatric patients with allergic diseases (basic group) and 53 children who at the time of examination and medical history of allergic diseases have been identified (control group). They have been studied in detail and life history of the disease and determined the level of vitamin D in the blood serum in the winter. Definition 25(OH)D was performed using elektrohemiluminestent method. Assessing vitamin D was carried out according to the classification of M.F. Holick et al. (2011). 
 

Results. Our study found that vitamin D deficiency is present in all examined children (53 patients) with allergies, the average hidroksykaltsyferolu was 22.54 nmol/l. In the control group of children examined vitamin D deficiency was found in 87.0%, the average was 34.20 nmol/L of vitamin D insufficiency was observed in 10.0%, the average was 64.50 nmol/l and in 3.0% of children had vitamin D in the normal range, the average was 79.50 nmol/l. The average vitamin D deficiency in the basic group of children was slightly lower than average vitamin D deficiency in children in the control group. 
 

Conclusions. The factors that affect the allergic processes in children include insufficient levels of vitamin D in the blood serum. 
 

Key words: screening, children, allergic disease, deficiency of vitamin D. 
 

REFERENCES

1. Квашніна ЛВ, Родіонов ВП, Оніськова ОВ. 2011. Застосування вітаміну D та його препаратів у сучасній педіатрії. Современная педиатрия 6(40): 68—71.

2. Peroni DJ, Piacentini GL, Cametti E, Chinellato I. 2011. Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children. Br J Dermatol 164(5): 1078—1082.

3. Holick MF, Binkley NC, Bischoff HA. 2011. Ferrari Evalution, treatment and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 96(7): 1911—1919.

4. Holick MF. 2008. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 87: 1080—1086.

5. Lips P, Hosking D, Lippuren K. 2006. The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation. J Intern Med 260: 245—254.

6. Pludovski P, Karczmarewicz E, Bayer M et al. 2013. Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe — recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynologia Polska 4(64): 319—327.

7. Brehm JM, Celedon JC, Soto-Quiros ME et al. 2009. The level of vitamin D and markers of severity of asthma in children in Costa Rica. J Respir Critical Care Med 179: 767—771.

8. Li F, Peng M, Jiang L et al. 2011. Vitamin D deficiency is associated with decreased lung function in Chinese adults with asthma. Breathing Epub 81(6): 469—475.

9. Chinellato I, Piazza M, Sandri M et al. 2011. Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr 158(3): 437—441.

10. Arshi Saba, Ghalehbaghi Babak, Seyyed—Kamran, Aminlou Mina 2012. Vitamin D serum levels in allergie rhinitis: any difference from normal population? Asia Pae Allergy 2(1): 45—48.

11. Wong GWK. 2008. Childhood Asthma epidemioligy: Insing from comparative studies of rurale and urban populations. J Pediatr Pulmon 43: 107—116.