SOVREMENNAYA PEDIATRIYA.2017.1(81):20-25; doi 10.15574/SP.2017.81.20

Marushko Y., Hyschak T.
National Bogomolets Medical University, Kyiv, Ukraine

The article shows the effectiveness of the drug Lizak on the main bacterial pathogens in the oropharynx such as St. aureus, Candida, E. coli. Lizak helped to

normalize the oropharyngeal microflora, which allows to recommend the drug widely for children's oropharynx sanitation.

Key words. Lizak, bacterial pathogens.

References

1. Dolgushin II et al. 2012. Vnekletochnyiy antimikrobnyiy mehanizm zaschityi neytrofilnyih granulotsitov. Vestnik Uralskoy med akadem nauki. 4(41): 30—31.

2. Voropaeva EA. 2013. Rol mikrobiotsenozov otkryityih polostey v formirovanii reaktivnosti organizma; diagnosticheskie kriterii disbiozov dlya otsenki sostoyaniya zdorovya cheloveka. Avtoref dis … d-ra biol nauk. 03.02.03, 14.03.09. Moskva: 38.

3. Klyueva LA. 2008. Mikroekologicheskie narusheniya i ih korrektsiya pri hronicheskom retsidiviruyuschem aftoznom stomatite (na primere g. Surguta). Dis … kand med nauk. 03.00.16. Surgut: 124.

4. Korolyuk AM. 2008. Ot prostakvashi Mechnikova k sovremennyim probioticheskim produktam funktsionalnogo pitaniya. Vestnik RAMN. 3: 146.

5. Afanasev SS et al. 2013. Mikrobiotsenozyi otkryityih polostey i mukozalnyiy immunitet. Effektivnaya farmakoterapiya. 27: 6—11.

6. Kocherovets VI et al. 2011. Mikroflora verhnechelyustnyih pazuh u detey s ostryim rinosinusitom. Rossiyskaya otorinolaringol. 3: 71.

7. Degtyarenko EV, Pershin SV, Yurina MS, Hoda S. 2012. Effektivnost primeneniya preparata «lizak» pri lechenii kataralnogo gingivita u podrostkov. Pytannia eksperymentalnoi ta klinichnoi medytsyny. Zb statei. 16; 2: 267—270.

8. Van den Bergh MR, Biesbroek G, Rossen JW et al. 2012. Associations between pathogens in the upper respiratory tract of young children: interplay between viruses and bacteria. PLoS One. 7(10): 47711. https://doi.org/10.1371/journal.pone.0047711; PMid:23082199 PMCid:PMC3474735

9. Belkaid Y, Hand TW. 2014. Role of the microbiota in immunity and inflammation. Cell. 157: 121—141. https://doi.org/10.1016/j.cell.2014.03.011; PMid:24679531 PMCid:PMC4056765

10. Blaser MJ, Falkow S. 2009. What are the consequences of the disappearing human microbiota. Nat Rev Microbiol. 7: 887—894. https://doi.org/10.1038/nrmicro2245; PMid:19898491

11. Bogaert D. 2011. Variability and diversity of nasopharyngeal microbiota in children: a metagenomic analysis. PloS one. 6: 17035. https://doi.org/10.1371/journal.pone.0017035; PMid:21386965 PMCid:PMC3046172

12. Andre GO et al. 2015. Combined effects of lactoferrin and lysozyme on Streptococcus pneumoniae killing. Microb Pathog. 89: 7—17. https://doi.org/10.1016/j.micpath.2015.08.008; PMid:26298002

13. Kamada N, Chen GY, Inohara N, Nunez G. 2013. Control of pathogens and pathobionts by the gut microbiota. Nat Immunol. 14: 685—690. https://doi.org/10.1038/ni.2608; PMid:23778796 PMCid:PMC4083503

14. Bomar L, Brugger SD, Yost BH et al. 2016. Corynebacterium accolens releases antipneumococcal free fatty acids from human nostril and skin surface triacylglycerols. mBio. 7(1): 1725—15. https://doi.org/10.1128/mBio.01725-15; PMid:26733066 PMCid:PMC4725001

15. De Steenhuijsen Piters WA, Sanders EA, Bogaert D. 2015. The role of the local microbial ecosystem in respiratory health and disease. Philos Trans R Soc B. 370.

16. Novak R et al. 2011. Effects of two probiotic additives containing Bacillus spores on carcass characteristics, blood lipids and cecal volatile fatty acids in meat type chickens. J Anim Physiol Anim Nutr (Berl). 95(4): 424—433. https://doi.org/10.1111/j.1439-0396.2010.01068.x; PMid:21039931

17. Hauser LJ, Ir D, Kingdom TT. 2016. Investigation of bacterial repopulation after sinus surgery and perioperative antibiotics. Int Forum Allergy Rhinol. 6(1): 34—40. https://doi.org/10.1002/alr.21630; PMid:26388320

18. Huang YJ. 2014. Airway microbiome dynamics in exacerbations of chronic obstructive pulmonary disease. Journal of clinical microbiology. 52: 2813. https://doi.org/10.1128/JCM.00035-14; PMid:24850358 PMCid:PMC4136157

19. Huang YJ, Lynch SV. 2011. The emerging relationship between the airway microbiota and chronic respiratory disease: clinical implications. Expert review of respiratory medicine. 5: 809. https://doi.org/10.1586/ers.11.76; PMid:22082166 PMCid:PMC3359942

20. Regev-Yochay G, Malley R, Rubinstein E, Raz M, Dagan R et al. 2016. In vitro bactericidal activity of Streptococcus pneumoniae and bactericidal susceptibility of Staphylococcus aureus strains isolated from cocolonized versus noncocolonized children. J Clin Microbiol. 46: 747—749. https://doi.org/10.1128/JCM.01781-07; PMid:18039795 PMCid:PMC2238136

21. Reid G et al. 2010. International Scientific Association for Probiotics and Prebiotics Responders and non-responders to probiotic interventions: how can we improve the odds? Gut Microbes. 1(3): 200—204. https://doi.org/10.4161/gmic.1.3.12013; PMid:21637034 PMCid:PMC3023600

22. Joslin SN. 2015. A Moraxella catarrhalis two-component signal transduction system necessary for growth in liquid media affects production of two lysozyme inhibitors. Infect Immun. 83(1): 146—160. https://doi.org/10.1128/IAI.02486-14; PMid:25312959 PMCid:PMC4288865

23. Klugman KP, Madhi SA. 2007. Pneumococcal vaccines and flu preparedness. Science: 316: 49—50. https://doi.org/10.1126/science.316.5821.49c; PMid:17412937

24. De Steenhuijsen Piters WA et al. 2016. Nasopharyngeal Microbiota, Host Transcriptome and Disease Severity in Children with Respiratory Syncytial Virus Infection. Am J Respir Crit Care Med. Epub ahead of print. https://doi.org/10.1164/rccm.201602-0220OC; PMCid:PMC4824929

25. Simone PM, Cook JL. 1995. Textbook of Diagnostic Microbiology: 831—832.

26. Vissers M. 2014. Severe viral respiratory infections: are bugs bugging? Mucosal immunology. 7: 227. https://doi.org/10.1038/mi.2013.93; PMid:24220300

27. Wouter AA. 2016. Unraveling the Molecular Mechanisms Underlying the Nasopharyngeal Bacterial Community Structure. mBio. 7(1): 9—16.