• Role of vitamin D deficiency in the development obstetric and perinatal complications (Literature review)
en To content

Role of vitamin D deficiency in the development obstetric and perinatal complications (Literature review)

HEALTH OF WOMAN. 2018.5(131):93–96; doi 10.15574/HW.2018.131.93

Korchinska O. O. , Loya N. O.
SHEI «Uzhgorod National University»

The article gives an overview of the literature that shows the high prevalence of deficiency and insufficiency of vitamin D in pregnant women in countries irrespective of their geographical location, leading to adverse health outcomes, such as miscarriage, premature birth defects, preeclampsia, gestational diabetes, risk Caesarean section, low birth weight and an increase in the number of autoimmune diseases associated with low levels of vitamin D during pregnancy.

Key words: vitamin D deficiency, pregnancy, obstetric complications, perinatal complications.

REFERENCES 

1. Komisarenko YuI. 2013. Vitamin D ta yoho rol u rehuliatsii metabolichnykh rozladiv. Lektsii, oglyady, novyny 4:51–54.

2. Maltseva LI, Vasileva EN, Denisova TG. 2016. Vitamin D i preeklampsiya. Rossiyskiy vestnik akushera-ginekologa 16;1:79–83.

3. Povorozniuk VV, Balatska NI. 2013. Defitsyt vitaminu D u naselennia Ukrainy ta chynnyky yoho rozvytku. Reproduktyvnaia endokrynolohiya 5(13):7–13.

4. Semin SG, Volkova LV, Moiseev AB, Nikitina NV. 2012. Perspektivyi izucheniya biologicheskoy roli vitamina D. Pediatriya 91(2):122–131.

5. Spirichev VB, Gromova OA. 2012. Vitamin D and its synergists. Zemskii vrach 2:33-38.

6. August P et al. 1992. Abnormal 1,25-dihydroxyvitamin D metabolism in preeclampsia. Am J Obstet Gynecol. 166;4:1295–1299. https://doi.org/10.1016/S0002-9378(11)90625-5

7. Arain N, Mirza WA, Aslam M. 2015, May. Vitamin D and the prevention of preeclampsia: A systematic review. Pak. J. Pharm. Sci. 28;3:1015–1021. PMid:26004709

8. Baker AM, Haeri S, Camargo Jr CA, Espinola JA, Stuebe AM. 2010. A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia. J Clin Endocrinol Metab. 95;11:5105–5109. https://doi.org/10.1210/jc.2010-0996; PMid:20719829 PMCid:PMC2968727

9. Bodnar LM, Platt RW, Simhan HN. 2015. Early-pregnancy vitamin D deficiency and risk of preterm birth subtypes. Obstet Gynecol. 125(2):439–447. https://doi.org/10.1097/AOG.0000000000000621; PMid:25569002 PMCid:PMC430496

10. Dawson-Hughes B, Mithal A, Bonjour J-P, Boonen S, Burckhardt P, Fuleihan GE-H, Josse RG, Lips P, Morales-Torres J, Yoshimura N. 2010. IOF position statement: vitamin D recommendations for older adults. Osteoporosis International 21;7:1151–1154. https://doi.org/10.1007/s00198-010-1285-3; PMid:20422154

11. Thiele Doria K, Jody Ralph, Maher El-Masri, Anderson Cindy M. 2017, January-February. Vitamin D3 Supplementation During Pregnancy and Lactation Improves Vitamin D Status of the Mother–Infant Dyad. Journal of Obstetrics, Gynecology and Neonatal Nursing 46;1:135–147. https://doi.org/10.1016/j.jogn.2016.02.016; https://doi.org/10.1016/j.jogn.2016.10.002; PMid:27840206

12. Powe CE et al. 2010. First trimester vitamin D, vitamin D-binding protein, and subsequent preeclampsia. Hypertension 56;4:758–763. https://doi.org/10.1161/HYPERTENSIONAHA.110.158238; PMid:20733087 PMCid:PMC3775612

13. Baker AM, Haeri S, Camargo CA et al. 2012. First-trimester maternal vitamin D status and risk of gestational diabetes (GDM): A nested case-control study. Diabetes/Metabolism Research and Reviews 28;2:164-168. https://doi.org/10.1002/dmrr.1282; PMid:21818838 PMCid:PMC4381548

14. Haeri S, Camargo CA Jr, Stuebe AM, Boggess KA. 2011. A nested case-control study of first-trimester maternal vitamin D status and risk for spontaneous preterm birth. Am J Perinatol 28(9):667–672. https://doi.org/10.1055/s-0031-1276731; PMid:21500145 PMCid:PMC4372898

15. Hensel KJ, Randis TM, Gelber SE, Ratner AJ. 2011. Pregnancyspecific association of vitamin D deficiency and bacterial vaginosis. Am. J. Obstet. Gynecol. 204;1:41 e1-41 e9.

16. Hewison M. 2010. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am. 39;2:365–379. https://doi.org/10.1016/j.ecl.2010.02.010; PMid:20511058 PMCid:PMC2879394

17. Bodnar LM, Simhan HN, Powers RW et al. 2007. High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates. Journal of Nutrition 137;2:447–452. https://doi.org/10.1093/jn/137.2.447; PMid:17237325 PMCid:PMC4288960

18. Holick MF. 2007. Medical progress: vitamin D deficiency. New England Journal of Medicine 357;3:266–281. https://doi.org/10.1056/NEJMra070553; PMid:17634462

19. Ota KDambaeva SHan ARBeaman KGilman-Sachs AKwak-Kim J. 2014. Vitamin D deficiency may be a risk factor for recurrent pregnancy losses by increasing cellular immunity and autoimmunity. Hum Reprod. 29:208–219. https://doi.org/10.1093/humrep/det424; PMid:24277747

20. Kovacs CS. 2008. Vitamin D in during pregnancy and lactation: maternal, fetal and neonatal outcomes from human and animal studies. Am J Clin Nutr. 88;2:520S–528S. https://doi.org/10.1093/ajcn/88.2.520S; PMid:18689394

21. Lapillonne A. 2010. Vitamin D deficiency during pregnancy may impair maternal and fetal outcomes. Medical Hypotheses 74;1:71–75. https://doi.org/10.1016/j.mehy.2009.07.054; PMid:19692182

22. Lau SL, Gunton JE, Athayde NP, Byth K, Cheung Yu. 2011. Serum 25-hydroxyvitamin D and glycated hemoglobin levels in women with gestational diabetes mellitus. Med. J. Aust. 194;7:334–337. PMid:21470081

23. Mahshid Taheri1 Azam Baheiraei, Abbas Ragimi Foroushani et al. 2015, June. Treatment of vitamin D deficiency is an effective method in the elimination of asymptomatic bacterial vaginosis: A placebo-controlled randomized clinical trial. Indian J Med Res 141:799–806.

24. Robinson CJ et al. 2011. Maternal vitamin D and fetal growth in early-onset severe pre-eclampsia. Am. J. Obstet. Gynecol. 204;6:556 e1-556 e4.

25. Bodnar LM. 2007. Maternal vitamin D deficiency increases the risk of pre-eclampsia. J Clin Endocrinol Metab. 92;9:3517–3522. https://doi.org/10.1210/jc.2007-0718; PMid:17535985 PMCid:PMC4288954

26. Gale CR, Robinson SM, Harvey NC et al. 2008. Maternal vitamin D status during pregnancy and child outcomes. European Journal of Clinical Nutrition. 62;1:68–77. https://doi.org/10.1038/sj.ejcn.1602680; PMid:17311057 PMCid:PMC2629513

27. Shand AW, Nassar N, Von Dadelszen P et al. 2010. Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia. BJOG: An International Journal of Obstetrics and Gynecology 117;13:1593–1598. https://doi.org/10.1111/j.1471-0528.2010.02742.x; PMid:21040394

28. Mirzakhani H et all. 2016, Dec 1. Early pregnancy vitamin D status and risk of preeclampsia. J Clin Invest. 126(12):4702–4715.  

29. Mithal A, Wahl DA, Bonjour JP , Burckhardt P, Dawson-Hughes B, Eisman JA, El-Hajj Fuleihan G, Josse RG, Lips P, Morales-Torres J. 2010. Global vitamin D status and determinants of hypovitaminosis D. Osteoporosis International 11;20:1821–1821. https://doi.org/10.1007/s00198-009-1030-y

30. Lanham-New SA, Buttriss JL, Miles LM et al. 2011. Proceedings of the rank forum on vitamin D. British Journal of Nutrition 105;1:144–156. https://doi.org/10.1017/S0007114510002576; PMid:21134331 PMCid:PMC3408594

31. Robinson CJ, Alanis MC, Wagner CL, Hollis BW, Johnson DD. 2010. Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia. American Journal of Obstetrics and Gynecology 203;4:366 e1-366 e6.

32. Liu NQ, Kaplan AT, Lagishetty V et al. 2011. Vitamin D and the regulation of placental inflammation. Journal of Immunology 186;10:5968–5974. https://doi.org/10.4049/jimmunol.1003332; PMid:21482732

33. Holmes VA, Barnes MS, Alexander HD et al. 2009. Vitamin D deficiency and insufficiency in pregnant women: A longitudinal study. British Journal of Nutrition 102;6:876–881. https://doi.org/10.1017/S0007114509297236; PMid:19331703

34. Haugen M, Brantsaeter AL, Trogstad L et al. 2009. Vitamin D supplementation and reduced risk of preeclampsia in nulliparous women. Epidemiology 20;5:720–726. https://doi.org/10.1097/EDE.0b013e3181a70f08; PMid:19451820

35. Hollis BW, Johnson D, Hulsey TC et al. 2011. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. Journal of Bone and Mineral Research 26;10:2341–2357. https://doi.org/10.1002/jbmr.463; PMid:21706518 PMCid:PMC3183324

36. Zhou J, Su L, Liu M, Liu Y, Cao X, Wang Z et al. Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China. Eur J ClinNutr.