- The role of mixed infection in pathological processes of the epithelium of the genitals with atypia of cells of unclear genesis in women with infertility
The role of mixed infection in pathological processes of the epithelium of the genitals with atypia of cells of unclear genesis in women with infertility
HEALTH OF WOMAN. 2019.8(144): 58–63; doi 10.15574/HW.2019.144.58
V.V. Kaminskiy1.2.3, V.V. Sumenko1.2, O.Y. Bondaruk1.2, I.O. Gak2.3
1Shupyk National Medical Academy of Postgraduate Education, Kiev
3USIR Shupyk National Medical Academy of Postgraduate Education, Kiev
3Kyiv City Center for Reproductive and Perinatal Medicine
The objective: In purpose to study the biocenosis and infectious agents of the urogenital tract in women with infertility combined with pathological processes of epithelium of the genitals with atypia of cells of unclear genesis.
Matirials and methods. 148 women with infertility and pathological processes of epithelium of the genitals with atypia of cells of unclear genesis were examined. The control group included 80 women with infertil.
All patients underwent cytological, bacterioscopic, bacteriological examination and polymerase chain reaction to diagnose urogenital tract infections.
Results. Dysbiosis of the microflora of the vagina was observed in women with infertility and the presence of pathological processes of the glandular epithelium of the genitals with atypia of cells of unclear genesis. Sexually transmitted infections are reported in 60.1% of patients. In the structure of sexually transmitted infections, prevailed mixed infections (mycoplasmosis associated with ureaplasmosis – 24.3%, and chlamydia with ureaplasmosis – 4.7%) and mono-infections (ureaplasmosis – 10.8%, mycoplasmosis – 13.5%, chlamydia – 4.7%). In 21.3% of cases was detected an association of human papillomavirus with sexually transmitted infections and vaginal dysbiosis. In most cases were observed highly oncogenic types of human papilloma virus, in particular, 18 type and similar types – 19.6%, 16 type and similar types – 8.8% and 45 type and similar types – 15.5%.
Conclusion. Due to the prevalence of fungi of the genus Candida, aerobic and anaerobic flora there is a violation of vaginal biocenosis in patients with infertility combined with pathological processes of the glandular epithelium of the genitals with atypia of cells of unclear genesis. Among the sexually transmitted infections are the most common mixed infection of M. genitalium + U. urealyticum and M. hominis + U. urealyticum, as well as mono-infection with urea-micoplasmosis and chlamydia. HPV is 6.2 times more higher than in the comparison group. Highly oncogenic types of HPV were detected in the structure of virus types with a significant difference, in particular, 18 type and similar types, 16 types and similar types. 45 type was determined only in patients with infertility combined with pathological processes of the glandular epithelium of the genitals with atypia of cells of unclear genesis.
Key words: pathological processes of the glandular epithelium of the genitals with atypia of cells of unclear genesis (AGC-NOS); infertility; biocenosis of vagina, sexually transmitted infections; human papilloma virus.
REFERENCES
1. Abakarova PR, Prilepskaya VN. 2017. VPCh-assotsiirovannyie zabolevaniya sheyki matki. Vozmozhnosti kompleksnoy terapii. Ginekologiya 19 (5): 4–9.
2. Abdrahmanov AR, Petrova AS, Abdrahmanov RM. 2018. Izmeneniya kletochnogo gomeostaza tkaney sheyki matki, assotsiirovannyie s uslovno-patogennyimi infektsiyami, peredavaemyimi polovyim putem. Sovremennyie problemy nauki i obrazovaniya 5: 90–90.
3. Boris EN, Gervazyuk OI. 2016. Analiz rezultatov vseukrainskogo issledovaniya primeneniya preparata Laferomaks v kompleksnoy terapii urogenitalnyih infektsiy i patologii sheyki matki u zhenschin razlichnogo vozrasta. Zdorove zhenschiny 9:33–39.
4. Prilepskaya VN i dr. 2019. Vaktsinatsiya kak effektivnyiy metod profilaktiki zabolevaniy sheyki matki, assotsiirovannyih s virusom papillomyi cheloveka (obzor literaturyi). Ginekologiya 2: 23–27.
5. Nazarova NM i dr. 2018. VPCh-assotsiirovannyie zabolevaniya u zhenschin i muzhchin: klinicheskie i prakticheskie aspektyi. Meditsinskiy opponent 4: 22–29.
6. Dobrohotova YuE. 2018. Imeyut li znachenie bakterialnyie infektsii, peredayuschiesya polovyim putem, v geneze neoplasticheskogo protsessa sheyki matki? RMZh. Mat i ditya 1: 62–66.
7. Frank Zhirardi, Olaf Rayh, Karl Tamussino, Helmut Pikel. 2018. Kolposkopiya i patologiya sheyki matki po Burghardtu. per. s angl.; pod red. prof. Prilepskoy VN. M, MEDpress-inform: 240.
8. Korobkov DM. 2016. Trubno-peritonealnoe besplodie u zhenschin reproduktivnogo vozrasta i ego kliniko-faktornyiy analiz. Byulleten nauki i praktiki 12: 186–189.
9. Suhanova AA i dr. 2016. Osobennosti VPCh-infektsii u zhenschin Ukrainyi. Obstetrics. Gynecology. Genetics. 2;2:12–22.
10. Pestrikova TYu, Yurasova EA, Kotelnikova AV. 2017. Harakteristika mikrobiotyi vlagalischa pri sochetanii bakterialnogo vaginoza s patologiey vlagalischa i sheyki matki vospalitelnogo geneza. Ginekologiya 4 (19): 15–19.
11. Murakov SV i dr. 2014. Retsidiviruyuschaya hlamidiynaya infektsiya i fonovyie zabolevaniya sheyki matki: patogeneticheskoe obosnovanie podhodov k lecheniyu. Meditsina kriticheskih sostoyaniy 1: 28–30.
12. Dobrohotova YuE i dr. 2016. Sovremennyiy podhod k lecheniyu displazii epiteliya sheyki matki umerennoy i tyazheloy stepeni na fone virusa papillomy cheloveka s primeneniem protivovirusnoy terapii. Lechebnoe delo 4: 52–56.
13. Andosova LD i dr. 2018. Sostav mikrobiotsenoza urogenitalnogo trakta i kolichestvennyie osobennosti papillomavirusnoy infektsii v zavisimosti ot tyazhesti VPCh-assotsiirovannogo tservikalnogo porazheniya. Meditsinskiy almanah 2: 23–26.
14. Syikina OI, Samoylova AV. 2019. Prichinyi neudach EKO u zhenschin s razlichnymi faktorami besplodiya. Molodezh v nauke: Novyie argumenty: 199–202.