PERINATOLOGIYA I PEDIATRIYA.2014.1(57):51-55; doi 10.15574/PP.2014.57.51 

Risk factors and prediction for functional and chronic inflammatory bowel diseases in infants

R.V. Marushko

State Institution «Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine», Kyiv, Ukraine

Objective — to determine mainly significant risk factors and prediction for development of functional bowel disease and chronic non-ulcerative non-specific colitis in infants.

Materials and methods. Retrospective studies were conducted using the method of questioning parents and analysis of medical records of 344 infants in the age from 6 months to 3 years of life, including 134 infants with functional constipation (FC) , 64 infants with functional diarrhea (FD) and 146 children with chronic non-specific not-ulcerative colitis (CNNC). The control group included 50 healthy children of similar age and gender. In groups of children retrospectively determined the frequency of risk factors. To compare the data between different groups was used analysis of Pearson c² criteria and relative risks (relative risk, RR) with 95% confidence intervals. Prediction for the development of FC, FD and CNNC was applied the method of discriminant function analysis based on the analysis of 51 essential marks.

Results. Mathematical analysis of risk factors for bowel diseases allowed to identify the most important of them, in particular, family history of diseases of the digestive system, including bowel disease, complications during pregnancy and at birth disorders, women chronic extragenital diseases, chronic diseases of women characterized by prolonged exposure in the body to opportunistic or pathogenic bacteria, nutritional and feeding disorders, high infection index and history of infectious diseases. Revealed by the discriminant function analysis significant risk factors, represent their important role in the development of functional bowel disorders and chronic non-specific non-ulcerative colitis.

Conclusions. Identifying the risk factors for the development and application of prediction algorithm for functional bowel diseases and chronic non-specific non-ulcerative colitis is enable to develop the effective treatment and preventive measures to reduce the frequency of bowel diseases and to prevent their formation in the early stages of life.

Key words: infants, risk factors, prediction, functional intestinal diseases, chronic non-specific non-ulcerative colitis.

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