Ukrainian Journal of Perinatology and Pediatrics. 2023. 1(93): 113-117; doi 10.15574/PP.2023.93.113
Denysova M. F., Gorban N. E., Muzyka N. M., Bukulova N. Yu.
SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine», Kyiv

For citation: Denysova MF, Gorban NE, Muzyka NM, Bukulova NYu. (2023). To the relevance of the problem of alimentary diseases in children. Ukrainian Journal of Perinatology and Pediatrics. 1(93): 113-117; doi 10.15574/PP.2023.93.113.
Article received: Dec 15, 2022. Accepted for publication: Mar 13, 2023.

Purpose – to highlight the problem of alimentary diseases in childhood and their connection with the factors of unbalanced nutrition.
An analysis of the literature on the role of unbalanced nutrition in the development of alimentary diseases in children and adolescents was carried out. The source of information for the analysis of questionnaires of adolescents (864 children) was the Ukrainian snippet of the international program ELSPAS (Europea Longitudinal Childhood), which made it possible to identify the interrelation of the nutritional characteristics of children with the risk of developing alimentary diseases.
According to the data from the literature and our own research, changes in the structure of non-infectious morbidity in both the adult and child population in the 20^th-21^st centuries due to an increase in the frequency of alimentary diseases are associated with a tendency to nutritional disorders, namely, unbalanced nutrition. Studies, conducted within the department indicate significant nutritional deficiencies of adolescents and young children, which contributes to the development of alimentary diseases in this group of patients.
The article shows the importance of the role of food as a risk factor for the development of inflammatory bowel disease due to the imbalance of the diet in terms of energy value, the prevalence of unrefined fats and carbohydrates in the diet, the lack of plant fiber, etc. This makes it possible to scientifically substantiate preventive programs to diagnose nutritional disorders in children and adolescents to prevent complex disabling diseases such as inflammatory bowel disease.
No conflict of interests was declared by the authors.
Keywords: children, alimentary diseases, inflammatory bowel disease, nutrition.
REFERENCES

1. Ananthakrishman AN, Khalili H, Konijeti GG et al. (2014). Long-term intake of dietary fat and risk of ulcerative colitis and Crohn's disease. Gut. 63: 776-784. https://doi.org/10.1136/gutjnl-2013-305304; PMid:23828881 PMCid:PMC3915038

2. Bukulova NYu, Denisova MF. (2020). Features of the clinic and diagnosis of ulcerative colitis in childhood according to a retrospective analysis. Nino Javakhishvili Scientific-Practical Journal Experimental & Clinical Medicine. 2 (12): 12-17.

3. Chan SS, Luben R, van Schaik F et al. (2021). Carbohydrate intake in the etiology of Crohn's disease and ulcerative colitis. Inflamm Bowel Dis: 20. https://doi.org/10.1097/MIB.0000000000000168; PMid:25265262 PMCid:PMC4213135

4. Chassaing B, Koren O, Goodrich JK et al. (2015). Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature. 519 (7541):92-96. https://doi.org/10.1038/nature14232; PMid:25731162 PMCid:PMC4910713

5. Denisova MF, Chernega NV, Muzika NN, Bukulova NY, Archakova TN, Reminnaia NT, Doroshenko OA. (2022). Features of the Clinic and Diagnosis of Crohn's Disease in Children at the Present Stage. World Science. 2: 74. https://doi.org/10.31435/rsglobal_ws/28022022/7779

6. Denysova MF, Muzyka NM. (2019). Teenage aggression as a consequence of improper nutrition. Perinatologiya and pediatriya. 1 (77): 79-84. https://doi.org/10.15574/PP.2019.77.79

7. Diachuk DD, Zabolotna IE, Yashchenko YuB. (2017). Obesity in children: risk factors and prevention tips. Sovremennaya Pediatriya. 2 (82): 42-46. https://doi.org/10.15574/SP.2017.82.42

8. Fasano A. (2020). All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases. F1000Res. 9: F1000 Faculty Rev-69. https://doi.org/10.12688/f1000research.20510.1; PMid:32051759 PMCid:PMC6996528

9. Fuller MK. (2019). Pediatric Inflammatory Bowel Disease: Special Considerations. Surg Clin North Am. 99 (6): 1177-1183. https://doi.org/10.1016/j.suc.2019.08.008; PMid:31676056

10. John S, Luben R, Shrestha SS et al. (2010). Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study. Eur J Gastroenterol Hepatol. 22: 602-606. https://doi.org/10.1097/MEG.0b013e3283352d05; PMid:20216220

11. Kapranov SV. (2011). Evaluation of the influence of the nourishment of various products on the functional state of the central nervous system at the senior schoolchildren. Arkhiv psykhiatrii. 17; 1 (64): 68-72. URL: http//nbuv.gov.ua/UJRN/apsuh-2011-17-1-17.

12. Koletzko B, von Kries R, Closa R, Escribano J, Scaglioniet S et al. (2009). Can infant feeding choices modulate later obesity risk? Am. J. Clin. Nutr. 89(5):1502S-1508S. https://doi.org/10.3945/ajcn.2009.27113D; PMid:19321574

13. Lee D, Albenberg L, Compher C et al. (2015). Diet in the pathogenesis and treatment of inflammatory bowel diseases. Gastroenterology. 148 (6): 1087-1106. https://doi.org/10.1053/j.gastro.2015.01.007; PMid:25597840 PMCid:PMC4409494

14. Liu JZ, van Sommeren S, Huang H et al. (2015). Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat Genet. 47: 979-986.

15. Loftus Jr EV. (2004). Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology. 126 (6): 1504-1517. https://doi.org/10.1053/j.gastro.2004.01.063; PMid:15168363

16. Magro F et al. (2017). Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders. J Crohns Colitis. 11 (6): 649-670. https://doi.org/10.1093/ecco-jcc/jjx008; PMid:28158501

17. McGuckin MA et al. (2009). Intestinal barrier dysfunction in inflammatory bowel diseases. Inflamm. Bowel Dis. 15: 100-113. https://doi.org/10.1002/ibd.20539; PMid:18623167

18. Niankovskyi SL, Shadrin OG, Klymenko VA et al. (2013). Kharchovi defitsyty u ditei pershykh 3 rokiv zhyttia za danymy multytsentrovoho doslidzhennia v Ukraini. Zdorove rebenka. 5 (48): 89-97. URL: http://www.mif-ua.com/archive/article/36722.

19. Pochynok TV. (2016). Iron deficiency anemia in children. Sovremennaya Pediatriya. 3 (75): 65-69. https://doi.org/10.15574/SP.2016.75.65

20. Powell DW. (1984). Physiological concepts of epithelial barriers. In: Mechanisms of mucosal protection in the upper gastrointestinal tract. Ed. Allen A. et al. Raven Press, New York: 1-6.

21. Roberts SE et al. (2020). A Systematic Review and Meta-analysis of Paediatric Inflammatory Bowel Disease Incidence and Prevalence Across Europe. J Crohns Colitis. 14 (8): 1119-1148. https://doi.org/10.1093/ecco-jcc/jjaa037; PMid:32115645

22. Samoshkin VV, Denysenko NM. (2018). Navchalnyi posibnyk. Kharchuvannia, zdorovia i khvoroby, zokrema khvoroby nedostatnoho abo nadlyshkovoho kharchuvannia (alimentarni zakhvoriuvannia) ta yikh profilaktyka. Dnipro: PDAFKiS: 70.

23. Shadrin OG, Niankovskyi SL, Umanets TR et al. (2012). Rekomendatsii shchodo vedennia ditei iz kharchovoiu alerhiieiu do bilka koroviachoho moloka. Dytiachyi likar. 7 (20): 27-42.

24. Shadryn OG, Haiduchyk GA. (2016). Problematic issues of infant feeding and the ways if its solutions Sovremennaia pedyatryia. 3 (75): 110-114. https://doi.org/10.15574/SP.2016.75.110

25. Shvets OV. (2018). Rekomendatsyy po pytanyiu dlia patsyentov s vospalytelnыmy zabolevanyiamy kyshechnyka. Medychna hazeta «Zdorovia Ukrainy». Tematychnyi nomer «Hastroenterolohiia. Hepatolohiia. Koloproktolohiia». 49: 16-17. URL: https://health-ua.com/article/39651-rekomendatcii-popitaniyu-dlya-patcientov-svospalitelnymi-zabolevaniyami-kis.

26.WHO. (2002). Infant and young child feeding and nutrition. Guidelines. European series. 87: 87.

27.WHO. (2022). Estimating the burden of foodbome diseases: a ptactical handbook for countries. URL: https://www.who.int/publications/i/item/9789240012264.

28. Wu GD, Bushmanc FD, Lewis JD. (2013). Diet, the human gut microbiota, and IBD. Anaerobe. 24: 117-120. https://doi.org/10.1016/j.anaerobe.2013.03.011; PMid:23548695

29. Zubar NM. (2006). Osnovy fiziolohii ta hihiieny kharchuvannia. Pidruchnyk. K.: KNTEU: 341.