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- HEALTH OF WOMAN WH_№9_2011
HEALTH OF WOMAN WH_№9_2011
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Read online Впервые в Европе родились двойняшки после применения уникальной технологи исследования генома!
9
Пархоменко Г. Я., Дудіна О. О.
Характеристика акушерсько-гінекологічної допомоги в Україні.
11
У статті наведені результати аналізу діяльності акушерсько-гінекологічної служби в Україні за період 2006–2010 років. Представлено аналіз основних показників результативності в розрізі регіонів країни.
Ginzburg V. G.
Quality of medical assistance to parturient women and new-borns in obstetrical hospitals upon accomplishment of organizational experiment.
16
Analysis, conducted upon implementation of complex organizational reforms aimed to the concentration of childbirth mainly in high-capacity obstetrical hospitals together with introduction of modern perinatal technologies and decrease of medicalization of childbirth, has shown that for most of the indicators quality of medical assistance to parturient women and new-borns in high-capacity obstetrical hospitals, where major share of childbirth delivery was done, is higher than in hospitals of lower capacity.
Kew words: quality of medical assistance, obstetrical hospitals of various capacity, puerperal, new-borns.
Nagornaya V. F., Starushchenko T. Ye.
Interferons are in therapy of chronic inflammatory diseases of genesial system, complicated by pre-cancer diseases.
22
Interferons are in therapy of chronic inflammatory diseases of genesial system, complicated by pre-cancer diseases. 150 patients with small pelvis-long recurrent chronic inflammative diseases have been examined. Herpes virus is identified in 100% of cases, and associated with human papillome virus type 130 in 86,7% of cases. In 100% the base-line or pre-cancer endometrial diseases and diseases of colli uteri were revealed. Alfa-interferons-2β in total course 20-60 millions of units during 2-6 months are included into complex treatment. Authors insist on prolonged interferone-therapy with intervals between injections 1-2 days in small pelvis-long recurrent chronic inflammative diseases.
Key words: chronic inflammative diseases, pre-cancer, alfa-interferons-2β.
Коновалова В. Н.
Дискуссионные вопросы тактики ведения женщин с доброкачественными заболеваниями молочных желез.
26
Siboulet А., Bohbot JM., Catalan F., Siboulet Ant.
Местная профилактика заболеваний, передающихся половым путем у женщин. Результаты, полученные при применении бензалкония хлорида в форме таблеток Фарматекс®.
33
In vitro бактерицидное и вируцидное действие спермицида бензалкония хлорида в форме таблеток Фарматекс®было доказано на бактериях возбудителей заболеваний, передающихся половым путем (ЗППП). Мы хотели уточнить его профилактическое действие в виде гинекологических таблеток, легко вводимых и имеющих высокую концентрацию активной субстанции. Чтобы объективно оценить эффективность in vivo, было проведено 2 исследования: одно в 1984 г. на 62 женщинах, другое в 1986 г. на 137 женщинах, наблюдаемых в течение первых 6 мес без профилактики заболеваний, передающихся половым путем (ЗППП), а затем в течение 6 мес с профилактикой ЗППП с помощью таблеток Фарматекса®. Каждая участница являлась своим собственным контролем (сравнивались данные периодов наблюдения одной и той же женщины. – Прим. ред.). После специфических строгих тестов контроля мы наблюдали уменьшение ЗППП на 39,7% в группе 1984 г. и на 43,6% – в группе 1986 г., в среднем – на 42%. Эти результаты особенно интересны превосходной переносимостью, наблюдаемой как у женщин, применяющих препарат, так и у их партнеров в период, когда еще не существует специфических вакцин.
Ключевые слова: местная профилактика, ЗППП, спермицид, переносимость, гинекологические таблетки, контрольный тест, бензалкония хлорид, Фарматекс®.
Sidorova I. S., Makarov I. O., Unanyan A. L.
Pathogenesis and pathogenetically substantiated therapy of chronic endometritis (сlinical lecture).
38
Chronic endometritis (CE) – a common disease with no unified concept of pathogenesis, characterized by undulating and ever-progressive pathological process. Important pathogenic factors contributing to the development of CE, is immune deficiency and violation of endometrium angioarchitectonics. Currently has been widely discussed question of the pro- and antioxidant systems imbalance role in the pathogenesis of HE. From these positions, it is obvious that the stimulation of natural antioxidant systems, introduction of exogenous antioxidants – one of the essential moments in the treatment of CE. Actovegin is a one of the modern drugs which is best meets the requirements of CE pathogenic-based therapy and has an impact on the above links of pathogenesis. Actovegin contains components with high biological activity: amino acids, oligopeptides, nucleosides, oligosaccharides and glycolipides, enzymes, electrolytes, and a number of important macro- and micronutrients. Exacerbation of already existing chronic inflammation often occurs after an abortion and therapeutic surgical procedures. Therefore, an important measure to prevent the exacerbation of chronic endometritis, an essential part of the treatment of post-abortion or postpartum CE, treatment and diagnostic curettage is the rehabilitation of structural and functional state of the endometrium with the use of Actovegin.
Key words: chronic endometritis, inflammation; abortion; Actovegin.
Zozula I. S., Chemer N. M.
Venous encephalopathy at pregnants (literature review).
41
The current work covers the question of venous cerebral circulation at pregnants of the first trimester of gestation. The literature review of etiology, pathogenesis, clinical presentation and possible treatment approach to the above problem was performed. The topicality and a lack of knowledge about venous cerebral circulation at pregnants has displayed.
Key words: cerebral venous discirculation, venous encephalopathy, pregnancy, literature review.
Romanenko T. G.
Prevention of gestational anaemia of the pregravid period women and during pregnancy.
45
Results of carried out experiments indicate that usage of vitamin and mineral complex (Emfetal) by women of anemia and gestational toxicosis progression high risk group during the pre-conceptional and pregnancy period permits to cut the likelihood of perinatal risk during the administration as part of pre-conceptional preparation; supplies pregnant women’s increased vitamin and mineral need; decreases danger of miscarriage risk, frequency and severity of gestational anemia and gestational toxicosis risk; normalizes functional condition of fetoplacental complex; contributes to better gestation course, birth and condition of a newborn.
Key words: pregravid period, anemia and gestational toxicosis, vitamin and mineral complex.
Stepanova N., Lebid L., Romanenko O.
Use of lactobacillus probiotics for prevention of recurrent urinary tract infections.
49
We analyzed the effectiveness of oral lactobacillus (probiotic Vagisan) for prevention of recurrent urinary tract infections. The use of oral probiotics is not inferior to antibiotic prophylaxis, significantly reduced the frequency of recurrence and has no side effects. For final conclusions it’s necessary to have further research on a representative sample of patients with definition of vaginal microflora in dynamic treatment.
Key words: lactobacillus probiotics, recurrent urinary tract infections.
Ухаль М. И., Ухаль О. М.
Антибактериальная терапия больных острым пиелонефритом беременных на современном этапе.
53
Romanenko Т., Ignatuk Т.
Prophylaxis of placental disfunction of infectious genesis.
55
The results of use of the Micogenaks and Utrogestan with the purpose of prophylaxis of placental disfunction of infectious genesis for pregnant of group of high risk ot it’s development are presented in the article. We have inspected 100 pregnant of group of high risk on development of placenta insufficiency and 50 ractically healthy pregnants. It is set as a result of the conducted researches, that forming and functional state of fetoplacental complex for pregnant of group of high risk of placenta insufficiency caused by infection, characterized by the considerable level of violations of the functional state of foetus, placentas, amounts of amniotic fluid, on a background the expressed haemodynamic and endocrinology violations. During a gestational process the these pregnant have the state of microbiocenosis of genital tracts, characterized by the progressive decline of amount of lactobacterium, bifidobacterium on a background the simultaneous increase of stamms of stphylococcus and other pathological microorganisms (ureo- and mycoplasms, chlamydia, escherichia, proteus). The use of offered medical and preventive methods allows to reduce frequency of placenta insufficiency, delay of height of featues, acuite urogenital infection, bacterial вагиноза.
Key words: placenta insufficiency, infection and pregnancy, endocrine function of fetoplacental complex, microbiocenosis of genital tracts, utrogestan, micogenacs, prophylaxis of placenta insufficiency.
Hrabous O. V.
Diagnostics and treatment of climacteric syndrome in women with an arterial hypertension.
60
In this article results of treatment of climacteric syndrome for women with an arterial hypertension are submitted. Supervision was conducted after two groups of women. Traditional therapy, directed on diminishing of disorders related to the climacteric syndrome and arterial hypertension, was conducted in the first group. In the second group treatment was conducted a method of hand-foot (Su Jok) acupuncture. High efficiency of treatment of climacteric syndrome was certain for women with an arterial hypertension by a method of hand-foot (Su Jok) acupuncture.
Key words: climacteric syndrome, arterial hypertension, hand-foot (Su Jok) acupuncture.
Енькова Е. В., Минаев Н. Н.
Оценка эффективности и комплаентности вагинальных капсул Полижинакс® при лечении неспецифических эндоцервицитов.
65
Jian-Claude Rouche, Christian de Chasteigner
Аб'юфен 400 мг і напади приливів Подвійне сліпе плацебо-контрольоване дослідження ефективності Аб’юфену 400 мг.
67
Веропотвелян Н. П., Бондаренко А. А., Коротков А. В.
Первая в Украине успешная пренатальная аспирация кисты яичника у плода и катамнестическое наблюдение в течение 16 лет.
70
Корнацька А. Г., Вовк І. Б., Чубей Г. В.
Досвід використання Диклоберлу в комплексній терапії запальних захворювань геніталій та аденоміозу.
73
Makarenko M. V.,. Govseiev D. O, Stanishevskaya M. L., Zhukova S. M., Aksenov V. B.
Experience of plasmapherese application in obstetrical practice.
76
Results of membrane plasmapherese application in treatment of several pathologies of pregnancy – choleostatic hepatosis, increased anti-body level in rhesus incompatibility, some non-specific diseases are presented in the article. Treatment of 35 patients at different pregnancy terms (14-35 weeks) was performed. It has been shown that plasmapherese procedures application during choleostatic hepatosis is efficient both is the first and second pregnancy halves. It enables quick improvement of patients’ general state and gradual decrease of transaminases level. In the case of rhesus incompatibility, application of plasmapherese allows twice decrease of antibody titers and is used for several times to prevent their repeated increase. Symptoms of different diseases manifested during pregnancy (herpes viral infection, myasthenia) are removed by therapeutic plasmapherese procedures.
Key words: plasmapherese procedures, rhesus incompatibility.
Vdovychenko J. P., Suhejl Sulejman Salama Abu Mustafa
Decrease ways of preeclampsia at multipara women.
81
The basic features of clinical current preeclampsia at women are investigated depending on parity. As have shown results of the lead researches use of a technique offered by us at multipara women allows to lower essentially frequency preeclampsia due to heavy forms, and also to improve perinatal outcomes delivery. Acknowledgement of clinical distinctions between groups is the functional condition fetoplacental a complex and decrease in frequency hemostaziological and hemodinamice infringements at multipara women.
Key words: preeclampsia, multipara women, preventive maintenance.
Romanenko T. G.
Chronic venous insufficiency during pregnancy – Lioton 1000 gel, the experience of health care use.
83
Pharmacologic therapy of chronic venous insufficiency based on the use of drugs whose action is aimed at stabilizing the structural components of the vein wall, increasing its tone and improvement of microcirculation. The article presents data on the efficacy of the drug Lioton-1000 gel in pregnant women in order to treat chronic venous insufficiency and prevention of venous complications.
Key words: сhronic venous insufficiency, treatment, prophylaxis, Lioton-1000 gel.
Veropotvelyan P. N., Veropotvelyan N. P., Pogulay Y. S.
Hyperhomocysteinemia and pregnancy.
87
The article gives an overview of the literature and summarizes a modern role of the polymorph variants of the MTHFR gene as well as the other forms of genetic trombophylia, detection of homocysteine concentration. It also shows the results of the investigation in 192 patients with habitual incompetence in their anamnesis. The data of the given overview and own examinations prove that hyperhomocysteinemia plays a very important role in the development of various obstetrical and perinatal pathology. Thus, detection of the MTHFR gene’s mutation and the level of homocysteine concentration in the blood serum is recommended to be included in patients while planning a pregnancy with a burdened obstetrical anamnesis.
Key words: hyperhomocysteinemia and pregnancy.
Vorobyova I. I., Mogilevska S. I., Zhivetskaya-Denisova A. A.
State immunity and especially micro biocenosis birth canal in women with threatened preterm labor.
91
It was investigated the immune system and reproductive tract micro biocenosis in 63 pregnant women with threatened preterm labor. Revealed marked changes in the direction of pathogenic organisms and disturbance indicators of immunity in pregnant women surveyed. After our proposed, the specific treatment had a significant improvement of the immune system and micro biocenosis of genital tracts.
Key words: preterm birth, the immune system, microbiocenosis of the vagina.
Lapko P. V., Malyar V. A.
The kliniko-laboratory complex estimation of effective treatment among pregnant women diagnosed with anaemia and hypothyriosis.
96
In article resulted the results of research, on foundation which it was set, that application among pregnant women on a background hypothyriosis developed by us treatment assists normalization of haematological indexes, level of folacin, hypophysis-thyroid system, ferokinetiks and improvement of indexes of delivery.
Key words: anaemia, hypothyriosis, hypophysis-thyroid system.
Подольський В. В., Писарєва С. П., Дронова В. Л., Подольський Вл. В.
Аналіз медико-соціального впливу впровадження сучасних медичних технологій на покращання репродуктивного здоров’я жінок з невиношуванням вагітності.
100
Зароченцева Н. В., Титченко Л. И., Титченко Ю. П., Меньшикова Н. С., Кашина Е. С.
Применение Флебодиа 600 у пациенток с варикозным расширением вен малого таза и синдромом тазовых болей.
103
Подольський В. В., Штул І. А.
Стан гіпофізарно-яєчникових гормонів репродуктивної системи в жінок із фоновою патологією шийки матки, що проживають у регіоні з природнім йододефіцитом.
107
Kazhina M. V., Chigareva L. F., Kovalenko L. V., Nekrashevich T. V., Ukolova A. M., Kaleichik Y. I.
Estimation of Zalain® effectiveness in therapy of candidal vulvovaginitis.
110
The article presents the results of the investigation of 43 women with candidal vulvovaginitis, who were treated by intravaginal introduction of Zalain®, a new antimycotic drug with innovation double mechanism of action. The perfect result of the treatment was noted at the final investigation (clinicomycological recovery). No complaints were registered; microscopy of vaginal smear was negative; there was no growth of Candida albicans at different nutrient mediums. Therapeutic effectiveness of Zalain® in our research was 90,7%. In addition to has a marked antimicotic action it influences effectively on conditionally pathogenic microorganisms. Side effects and allergic reactions weren’t observed. Zalain® is effective, safe and easy-to-use drug. Even single course of treatment with Zalain® allows to increase efficiency and convenience of therapy of candidal vulvovaginitis, and can be recommended for wide application in obstetric-gynecologic practice.
Key words: candidal vulvovaginitis, Zalain®.
Romanenko T. G., Gopchuk E. N.
Efficiency of Magne-В6 administartion in autonomic disturbances correction to women with climacteric syndrome.
115
Results of own research of efficiency of correction of vegetative disorders at women with a climacteric syndrome by preparation Magne-В6 are presented. Two schemes of treatment were used – hormonal replacement therapy and preparations of calcium and hormonal replacement therapy in combination with Magne-В6. Both therapeutic schemes have appeared effective in a daily practice. However results of research show efficiency of application of Magne-В6 on a background of hormonal replacement therapy for correction of vegetative disorders at women with a climacteric syndrome.
Key words: climacteric syndrome, Magne-В6, treatment, prophylaxis.
Kovalenko Ye. P., Tatarchuk T. F., Litvinova S. V., Kubyshkin A. V.
Changes in the local nonspecific proteases activity and level of their inhibitors in endometrial hyperplasia.
118
Changes in the nonspecific proteases activity and level of their inhibitors in uterine lavage fluid of women with different types of endometrial hyperplasia it was studied. Formation of endometrial hyperplasia is accompanied by the development of an imbalance in the state of local non-specific proteinases and their inhibitors, which shows the growth of trypsin-and elastase-like activity and decrease of local synthesis of acid-stable proteinase inhibitors. The most significant changes it was found in complex endometrial hyperplasia. The inflammatory process in the urogenital system leads to more increase of proteinase activity in uterine lavage fluid and reduce antiproteinase activity. Assessment of the changes in proteases and their inhibitors in uterine lavage fluid can be used as criteria for the formation of inflammatory changes in the endometrium during hyperplasia development, to assess the prognosis of hyperplasia, the risk of endometrial malignancy and the efficiency of the treatment.
Key words: endometrial hyperplasia, inflammation, proteinases, proteinase inhibitors.
Макарчук О. М., Бойчук Л. Г., Юнгер В. І., Островська О. М., Мегедин І. В.
Особливості функціональної здатності печінки у жінок з фіброміомою матки на тлі захворювань гепатобіліарної системи.
122
Гіперпластичні процеси матки належать до найбільш поширених захворювань жіночих статевих органів. Метою дослідження було провести оцінку білкового обміну та функціонального стану гепатоцитів у жінок з фіброміомою матки і порушенням функції гепатобіліарної системи. Під час дослідження були використані такі сучасні методи: вивчення спектра сироваткового білка методом диск-електрофорезу в поліакриламідному гелі та окремі інструментальні дослідження (УЗ), а також проведений клініко-параклінічний аналіз історій хвороб 150 жінок з фіброміомою матки у віці від 35 до 45 років, які лікувалися в гінекологічному відділенні обласного перинатального центру м. Івано-Франківськ. На підставі отриманих результатів зроблено висновки, що в жінок з фіброміомою матки на тлі порушення функції гепатобіліарної системи виникають значні зміни показників білкового обміну, які залежать від преморбідного фону й тяжкості дисгормональних порушень та проявляються гіпо- і диспротеїнемією, гіпоальбумінемією, відсутністю синтезу окремих білків зони повільних і швидких посттрансферинів. Причому таке глибоке ураження гепатоцитів може бути незворотним, що вимагає патогенетичної корекції шляхом включення до курсу лікування препаратів з гепатопротекторною, антиоксидантною та ангіопротекторною дією.
Ключові слова: фіброміома матки, захворювання гепатобіліарної системи, білковий обмін, диск-електрофорез білка.
Сергиенко М. Ю., Яковлева Э. Б., Филипова Н. Г.
Роль экстренной контрацепции в сохранении репродуктивного здоровья подростков и молодых женщин.
125
Mosyenko G. P.
State of health in adolescents with functional disorders of the digestive system who are smoking.
129
The author has examined the effect of smoking in 52 adolescents with functional disorders of the digestive system. The article represents peculiarities of changes of vegetative nervous system, analysis of vegetative homeostasis in adolescents who are smoking what should be important for treatment functional disorders of the digestive system.
Key words: functional disorders of the digestive system, vegetative nervous system, heart rate variability, adolescents, smoking.
Vovk I. B., Trohimovych O. V., Dikan I. M., Volyk N. K.
Dopplerometry estimation of the primary breach of preplacentas hemodynamic.
131
The studied particularities of preplacentas hemodynamic in 35 women with threat of the interruption to pregnancy at 6–11 weeks terms. The got results of the studies of uterine hemodynamic in womans with threat of the interruption to pregnancy were indicative of presence of the breach uterine perfusion that revealled itself the reduction to intensities uterine hemodynamic and, accordingly, reliable increasing index vascular resistance in subdominant of the uterine artery. The changes of uterine hemodynamic are an independent sign of the threat of the interruption to pregnancy that can be used for forecasting of probability of the reproductive losses.
Key words: preplacentas hemodynamic, dopplerometry, early pregnancy losses.
Gordienko I. Y., Tarapurova O. M., Grebinichenko G. O., Nikitchina T. V., Nosko A. O., Podolskiy Vl. V.
Prenatal diagnosis in multiple and singleton pregnancies after use of assisted reproductive technology.
134
In the article was conducted a comparative analysis of the rate and structure of fetal congenital and hereditary pathology in twin and singleton pregnancies after use of assisted reproductive technologies and in spontaneous pregnancy.
Key words: singleton pregnancy, twins, prenatal diagnosis, congenital malformations, chromosomal pathology, assisted reproductive technologies.
Manasova G. S.
Features of the development of the bone-muscular system of children during of the first life’s year, transferred infection’s influence during intrauterine period.
138
Comparative dynamic supervision over development of bone-muscular system of children of the first life’s year, born at the women with perinatal infection and pathology of the bone tissue and at healthy women is lead. The condition of the bone-muscular system of children was estimated at anthopometrical inspection at a birth, then on rates of the set of the weight and growth, formation and becoming of the basic statically-dynamic functions in the age of 1–2, 6–8 and 12 months. At a birth attributes of an insufficient mineralization of the bone system were available for each third child from the basic group. Development of the bone-muscular system of these children was characterized authentically by lower rates of the set of the weight and growth and slow formation and becoming of the static and dynamic functions. Possibly, children who have transferred of the perinatal infection’s influence in the intrauterine period, should be allocated in the group of risk on development of the pathology of the bone-muscular system and their physical development should be under the special control.
Kew words: children, perinatal infection, bone-muscular system.
Borysyuk O. Ju.
Clinical and microbiological efficiency of complex application of preparations of Hemomicyn® and inductor of interferon Lavomax® for treatment of women with chronic inflammatory diseases of genitals caused by mixed chlamydia trachomatis and ureaplasma urealyticum infections.
142
Conducted clinical-laboratory research of efficiency of complex application of makrolyd antibiotic of Hemomicyn® and inductor of interferon Lavomax® (tyrolon 125 mg, tablets) in treatment 50 women of fertile age with chronic inflammatory diseases of genitals caused by mixed chlamydia trachomatis and ureaplasma urealyticum infections. Exposed, that complex application of the indicated preparations testifies to high efficiency this kind of treatment, that allows to recommend their complex application to the widest introduction in practice.
Key words: chronic inflammatory diseases of genitals, chlamydia trachomatis, ureaplasma urealyticum, makrolyd antibiotic of Hemomicyn®, an inductor of interferon Lavomax® (tyrolon).
Mezhevitinova E. A., Abakarova P. R.
Efficiency of treatment of urogenital trichomoniasis.
147
Background: Urogenital trichomoniasis is one of the most common sexually transmitted diseases.
Patients: Eighty four nonpregnant outpatients with a diagnosis of urogenital trichomoniasis were enrolled into this study. Mean age was 29,7±9,2 yr. Exclusion criteria: intolerance of nitroimidazole compounds, use of antibacterial agents within one month prior to the study; renal and/or hepatic insufficiency, mixed infections involving other than T. vaginalis agents of sexually transmitted diseases.
Therapy: All patients were administered Trichopol® (metronidazole) 250 mg t.i.d. orally for seven days and 500 mg intravaginally for seven nights.
Main outcome measures: Clinical and microbiologic follow-up evaluations were scheduled for 1, 4, and 12 weeks posttreatment. Patients were also interviewed for remaining signs and symptoms and adverse events.
Results: Bacteriological elimination was achieved in 78 patients following the results of evaluations at one and four weeks posttreatment. In six patients failing to achieve bacteriological elimination the initial treatment was prolonged for 5 additional days. Three months posttreatment clinical success and bacteriological elimination were achieved in all 84 patients.
Conclusions: Combination of oral and intravaginal administration of Trichopol® appears to be an effective and safe treatment of symptomatic urogenital trichomoniasis in nonpregnant women.
Key words: urogenital trichomoniasis, Trichopol, metronidazole.
Linnikov V. I.
Pregravidar preparation of women with syndrome of loss of a fetus and herpeviral infection.
153
The aim was to study the effect of combined use of medication and immunotherapy in preparation for the planned pregravidar pregnant women with syndrome of loss of a fetus and antiphospholipid syndrome, caused by herpesvirus infection. It is established that the application of immunorecombinant human interpheron alpha-2β-Alpharekin®, patients normalize the immune and interferon status with a clear upward trend in the relative content of T- lymphocytes and immunoregulatory index due to the increase of T-helper cells, which allowed the gestational process takes place in best supportive conditions.
Key words: syndrome of loss of a fetus, herpeviral infection, antiphospholipid syndrome, immunomodulater Alpharekin®.
Ysachova E. V.
Impact of acute forms of herpetic infectious on course of pregnancy, childbirth and neonatal period and effectiveness its correction.
158
On the background of analysis course of pregnancy, childbirth and neonatal period in 79 patients, among them 56 had acute forms of herpetic infectious during pregnancy, it has been shown pathological impact of persistent viruses and possibility its correction by combined therapy of Specific immunoglobulin and Hofitol.
Key words: herpes viruses 1 and 2 types, cytomegalovirus, acute forms, pregnancy, childbirth, newborn, treatment, morphological changes of placenta.
Korobko E. N.
Role of complex diagnostics of a cavity of a uterus in increase of efficiency of treatment of female barreness after unsuccessful attempts auxiliary reproductive technologies.
163
The analysis of matematiko-statistical interrelations has allowed to reveal presence of communications between result auxiliary reproductive technologies and various anamnese data, level of receptors to sexual hormones, and also their concentration in peripheral blood. On our opinion the obtained data can serve me as a substantiation of criteria of ability of implantation of endometrium and testify to necessity of dynamic researches of the hormonal status of patients, levels of receptors in endometrium to sexual hormones. It is obvious, that comparison of these factors to anamnesis data should be carried out at carrying out of a complex of actions for preparation endometrium in the program auxiliary reproductive technologies.
Key words: female barreness, auxiliary reproductive technologies, a pathology of a cavity of a uterus.
Чермак И. И.
Тактика лечения бесплодия у женщин позднего репродуктивного возраста с генитальным эндометриозом.
165
Результаты проведенных исследований свидетельствуют, что при наличии сочетанного повреждения эндометриоидным процессом яичников и матки у большинства пациенток регистрируется низкий и крайне низкий овариальный резерв, что обусловливает необходимость использования ооцитов донора после предварительной оперативной и консервативной терапии.
Ключевые слова: бесплодие, поздний репродуктивный возраст, генитальный эндометриоз, лечение.
Hourani I. F.
Quercitin and thiotriazoline effect on the severity of oxidative stress in patients with breast cancer with gene MTHFR and MMP-12 mutations after chemoradiation treatment.
169
The influence of MTHFR and MMP-12 gene mutations on lipids peroxidation activity, protein carbonylation and the destruction of collagen caused by chemo-radio therapy in patients with breast cancer was studied. Most significantly the level of MDA, protein carbonyl and oxyprolin groups increase in patients with homozygous TT allele MTHFR gene, these deviations are the lowest in the homozygous CC (wild type). Usage of quercitin and thiotriazoline significantly reduces oxidative stress phenomena and processes of collagen destruction in homo-and heterozygous carriers of the T-allele and almost eliminates them in the wild-type homozygote MTHFR gene.
Key words: breast cancer, chemo-radio therapy, MTHFR and MMP-12 mutations, oxidative stress, quercitin, thiotriazoline.
Toryanik E. L.
Status at vascular endothelial of experimental preeclampsia in SHR-female rats.
173
It is proved that pregnant female rats, spontaneously hypertensive (SHR-female rats) the introduction of an aqueous solution N-nitro-L-arginine causes the symptoms of endothelial dysfunction and increased systolic blood pressure, the expression of endothelin, which are morphologically verified. Development of preeclampsia in pregnant SHR-female rats is accompanied by certain structural and functional changes in the utero-placental complex, dominated by hemodynamic disturbances body.
Key words: pregnancy, preeclampsia, endothelial dysfunction, arterial hypertension.