• Progress’s features of the heredity and acquired angioedema, chronic spontaneous urticaria at the examles of clinical cases
en To content Full text of article

Progress’s features of the heredity and acquired angioedema, chronic spontaneous urticaria at the examles of clinical cases

SOVREMENNAYA PEDIATRIYA.2018.7(95):59-64; doi 10.15574/SP.2018.95.59

Zubchenko S. O., Sharikadze O. V., Marunyak S. R., Lomikovska M. P., Potemkina G. O.
Danylo Halytsky Lviv National Medical University, Ukraine
Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine

Today the number of patients, including childhood, with isolated angioedema (AN) and AN with urticaria and itching significantly increased. These pathological manifestations oftenare not acquired by traditional methods of therapy. Therefore practical doctors should get deeper knowledge about the etiological and pathogenetic mechanisms of this disease.

Aim. The purpose of our work was to show the complexity of the diagnostic searches and the diversity of manifestations of angioedema and chronic spontaneous urticaria in patients of different age groups on the example of clinical cases.Modern approach to classification, diagnostics, including differential and management of patients with angioedema of different genesis is presented at the initiative of leading scientists and doctors of the World Allergy Organization (WAO) and the European Academy of Allergology and Clinical Immunology (EAACI) in the renewed consensus «The international WAO / EAACI guideline for the management of hereditary angioedema — The 2017 revision and update».

Conclusion.The study of the basic principles outlined in the renewed consensus will enable practicing doctors to timely diagnose the diagnosis and to provide adequate therapy.

Key words: angioedema, angioedema, chronic spontaneous urticaria, diagnosis, therapy.

REFERENCES

1. Bafunno V, Firinu D, D'Apolito M et al. (2018, Mar). Mutation of the angiopoietin-1 gene (ANGPT1) associates with a new type of hereditary-angioedema. J Allergy Clin Immunol. 141(3):1009—1017. doi 10.1016/j.jaci.2017.05.020. pii: S0091-6749(17)30921-1.

2. Binkley KE, Davis A 3rd. (2000). Clinical, biochemical, and genetic characterization of a novel estrogen-dependent inherited form of angioedema. J Allergy Clin Immunol.106:546—550. https://doi.org/10.1067/mai.2000.108106; PMid:10984376

3. Bork K, Meng G, Staubach P, Hardt J. (2006). Hereditary angioedema: newfindings concerning symptoms, affected organs, and course. Am J Med.119:267—274https://doi.org/10.1016/j.amjmed.2005.09.064; PMid:16490473

4. Caldwell JR, Ruddy S, Schur PH, Austen KF. (1972). Acquired C1 inhibitordeficiency in lymphosarcoma. Clin Immunol Immunopathol.1:39—52. https://doi.org/10.1016/0090-1229(72)90006-2

5. Ebo DG, Van Gasse AL, Sabato V et al. (2017). Hereditary angioedema in 2 sisters due to paternal gonadal mosaicism. J Allergy Clin Immunol Pract. 6:277—279. https://doi.org/10.1016/j.jaip.2017.07.002; PMid:28888847

6. Farkas H, Gyeney L, Gidofalvy E, Fust G, Varga L. (1999). The efficacy of short-term danazol prophylaxis in hereditary angioedema patient sundergoing maxillofacial and dental procedures. J Oral Maxillofac Surg. 57:404—408. https://doi.org/10.1016/S0278-2391(99)90280-X

7. Lopez-Lera A, Garrido S, Roche O, Lopez-Trascasa M. (2011). SERPING 1 mutations in 59 families with hereditary angioedema. Mol Immunol.49:18—27. https://doi.org/10.1016/j.molimm.2011.07.010; PMid:21864911

8. Maurer M, Aberer W, Bouillet L et al. (2013). Hereditary angioedemaat-tacks resolve faster and are shorter after early icatibant treatment. PLoS One.8:e53773. https://doi.org/10.1371/journal.pone.0053773; https://doi.org/10.1371/annotation/ab8fe636-8b5b-420e-9cbf-1bef0a19b63f; PMid:23390491 PMCid:PMC3563637

9. Pedrosa M, Phillips-Angles E, Lopez-Lera A, Lopez-Trascasa M, Caballero T. (2016). Complement study versus CINH gene testing for thediagnosis of type I hereditary angioedema in children. J Clin Immunol.36:16—18. https://doi.org/10.1007/s10875-015-0222-9; PMid:26661330

10. Zanichelli A, Vacchini R, Badini M, Penna V, Cicardi M. (2011). Standard-care impact on angioedema because of hereditary C1 inhibitordeficiency: a 21-month prospective study in a cohort of 103 patients. Allergy.66:192—196. https://doi.org/10.1111/j.1398-9995.2010.02433.x; PMid:21039598

Article received: May 27, 2018. Accepted for publication: Nov 03, 2018.