HEALTH OF WOMAN.2015.5(101):32–36; doi 10.15574/HW.2015.101.32
 

Prognostic value of low levels of estradiol, progesterone and their ratio in women with acute coronary syndrome with ST-segment elevation in postmenopause
 

Netyazhenko N. V.

A.A. Bogomolets National Medical University, Kiev
 

In women in early postmenopausal period was studied the prognostic impact of clinical and anamnesis, data obstetric history and serum levels of estradiol, progesterone and estradiol/ progesterone ratio (EPR) on the course of acute coronary syndrome (ACS) with ST-segment elevation during hospital period.

Multiple regression analysis revealed that a decrease in estradiol levels <45.14 pg/ml (sensitivity – 88.4%, specificity – 89.2%) increased occurrence of major adverse events in 1.9-fold (odds ratio (OR) 1.9; 95% confidence interval (CI) (0.96–2.4)). Reducing EPS <12.117 pg/ng (sensitivity – 91,5%, specificity – 76,4%) increases the risk of critical events in 1.4 times (VSH – 1.44; 95% CI 0.87–1.99).

Personalized short-term prediction of clinical course of ACS with ST-segment elevation in women in early postmenopausal period associated with estradiol concentrations below 45.14 pg/ml and EPS below 12.117 pg/ng, to predict the development of adverse cardiovascular events ACS with high sensitivity and specificity.
 

Key words: estradiol, progesterone, myocardial infarction, postmenopause.
 

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