• Primary anastomosis in the management of newborns with necrotizing enterocolitis 
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Primary anastomosis in the management of newborns with necrotizing enterocolitis 

Primary anastomosis in the management of newborns with necrotizing enterocolitis 
 

Pereiaslov A. A., Borys O. Ya., Shakhov K. V.

Lviv National Medical University named after Danylo Halytskyi, Ukraine

Ivano-Frankivsk National Medical University, Ukraine


Necrotizing enterocolitis (NEC) — one of the lifethreatening diseases of newborns associated with the high (20–40%) mortality. Decision about the method of completing surgical intervention after the removal of necrotic changed bowel — stoma formation or primary anastomosis — is still under discussion.

The objective of the study was to summarize own experience of using primary anastomosis in the management of newborns with NEC.


Material and methods. The study was based on the outcomes of surgical treatment of 62 newborns with the different degree of NEC severity. The diagnosis was established on the basis of objective examination and instrumental methods (X-ray, ultrasound and Doppler). In 41 (66.1%) newborns after intestine resection the stoma was made, and in 21 (33.9%) — the surgery was completed by the primary anastomosis.


Results and discussion. Total mortality among newborns after surgical treatment was 17.7% (11 newborns), in particular after stoma formation — 19.5% (8 newborns) and after primary anastomosis — 14.3% (3 babies). Various postoperative complications developed in 17 (41.5%) children after the stoma formation and in 5 (23.8%) patients after the primary anastomosis. The problem of the choice of method for surgery completion in children with NEC should be decided individually, taking into account the prevalence of necrotic changes in the bowel, hemodynamic status during surgery and surgeon experience. The use of intraoperative Doppler ultrasonography enables to clearly identify intestinal areas with absent or decreased blood flow, which gives the opportunity to perform bowel resection within healthy tissues.


Conclusions. Our researches confirmed that the primary anastomosis in the presence of clear indications is a safe and effective treatment in infants with NEC associated with lesser complications and lower mortality.


Key words: necrotizing enterocolitis, surgical treatment, primary anastomosis.


References

1. Aguayo P, Fraser JD, Sharp S et al. 2009. Stomal complications in the newborn with necrotizing enterocolitis. J Surg Res. 157: 275-278.

2. Blakely ML, Gupta H, Lally KP. 2008. Surgical management of necrotizing enterocolitis and isolated intestinal perforation in premature neonates. Semin Perinatol. 32: 122-126.

3. Cheng W., Leung M.P., Tam P.K. 1999. Surgical intervention in necrotizing enterocolitis in neonates with symptomatic congenital heart disease. Pediatr Surg Int. 15: 492-495.

4. Dominguez KM, Moss RL. 2012. Necrotizing enterocolitis. Clin Perinatol. 39: 387-401.

5. Eltayeb AA, Mostafa MM, Ibrahim NH, Eltayeb AA. 2010. The role of surgery in management of necrotizing entero colitis. Intern J Surg. 8: 458-461.

6. Gfroerer S, Fiegel H, Schloesser RL, Rolle U. 2014. Primary laparotomy is effective and safe in the treatment of necrotizing enterocolitis. World J Surg. 38: 2730-2734.

7. Guelfand M, Santos M, Olivos M, Ovalle A. 2012. Primary anastomosis in necrotizing enterocolitis: the first option to consider. Pediatr Surg Int. 28: 673-676.

8. Hall NJ, Curry J, Drake DP et al. 2005.Resection and primary anastomosis is a valid surgical option for infants with necrotizing enterocolitis who weigh less than 1000 g. Arch Surg. 140: 1149-1151.

9. Hall NJ, Eaton S, Pierro A. 2013. Necrotizing enterocolitis: Prevention, treatment, and outcome. J Pediatr Surg. 48: 2359-2367.

10. Hull MA, Fisher JG, Gutierrez IM et al. 2014. Mortality and management of surgical necrotizing enterocolitis in very low birth weight neonates: a prospective cohort study. J Am Coll Surg. 218: 1148-1155.

11. Kastenberg ZJ, Sylvester KG. 2013. The surgical management of necrotizing enterocolitis. Clin Perinatol. 40: 135-148.

12. Kelleher J, Mallick H, Soltau TD et al. 2013. Mortality and intestinal failure in surgical necrotizing enterocolitis. J Pediatr Surg. 48: 568-572.

13. Kiesewetter WB, Taghizadeh F, Bower RJ. 1979. Necrotizing enterocolitis: is there a place for resection and primary anastomosis? J Pediatr Surg. 14: 360-362.

14. Pierro A, Hall N. 2003. Surgical treatments of infants with necrotizing enterocolitis. Semin Neonatol. 8: 223-232.

15. Raval MV, Hall NJ, Pierro A, Moss RL. 2013. Evidencebased prevention and surgical treatment of necrotizing enterocolitis. A review of randomized controlled trials. Semin Pediatr Surg. 22: 117-121.

16. Raval MV, Moss RL. 2014. Current concepts in the surgical approach to necrotizing enterocolitis. Pathophysiology. 21: 105-110.

17. Singh M, Owen A, Gull S et al. 2006. Surgery for intestinal perforation in preterm neonates: anastomosis vs stoma. J Pediatr Surg. 41: 725-729.

18. Thyoka M, de Coppi P, Eaton S et al. 2012. Advanced necroti zing enterocolitis. Part 1. Mortality. Eur J Pediatr Surg. 22: 8-12.

19. Vanamo K, Rintala R, Lindahl H. 2004. The Santulli entero stomy in necrotising enterocolitis. Pediatr Surg Int. 20: 692-694.