PERINATOLOGIYA I PEDIATRIYA.2013.4(56):108–110

Preventive ferrotherapy at the preclinical stage of iron deficiency in adolescent girls

Sulzhenko M. Yu., Golovchenko N. N.

SI «Lugansk State Medical University», Lugansk, Ukraine

Background. Particularly liable to iron deficiency anemia (IDA) are adolescent girls. The prevalence of pre clinical stages of iron deficiency (ID) in this category is even higher. It is known that the removal of IDA can be caused not only with diet. In addition, dietary correction of latent ID is not always effective, especially among teenage girls, who often have a strong negative iron balance in the body due to menstrual blood loss. Aim. To study the effectiveness of prevention of IDA.

Methods. The dynamic examination for a year of 143 adolescent girls (12–17 years) with pre-clinical stage of the ID was performed. Group I (n=45) was appointed to iron at a dose of 1 mg / kg per day in the 1st 10 days of each menstrual cycle for 6–12 cycles, depending on the stage of the ID, along with a diet rich in iron, and group II (n=48) — only dietary correction, in group III (n=50) preventive measures were carried out. After 12 months of follow-up visit we conducted ferrokinetics, hematopoiesis.

Results. Indicators hemogram, erythrocyte indices, as well as transport and tissue iron stores in group I after 12 months on average, almost no different from those in healthy girls, also showed no adverse effects from low doses and short term use. However, in group II there were significant declines in blood counts, exhaustion and transport of tissue iron stores continued, and even noted the development of IDA in 35.4±6.9% of cases. Only dietary correction ID sometimes not adequately saturate iron stores even in preclinical stages, particularly in girl's puberty, when they need additional iron supplementation. The lack of preventive measures in the control group resulted in a significant increase in the level of the ID.

Conclusions. Thus, our data support the effectiveness of iron prophylaxis IDA in adolescent girls in preclinical stages.

Key words: preventive ferrotherapy, iron deficiency states, teenage girls.

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