PERINATOLOGY AND PEDIATRIC. UKRAINE. 2017.3(71):44-49; doi 10.15574/PP.2017.71.44

Podolsky Vl. V., Podolsky V. V.
SI «Institute of Paediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv, Ukraine

Objective. To present the results of the vaginal microbiocenosis study in women with uterine leiomyoma and inflammatory diseases of the genital organs; to optimize the prevention and treatment of inflammatory changes of the genital organs in fertile aged women with these pathologies.
Material and methods. We examined 150 fertile aged women, who were divided into three groups: I group — 50 women with leiomyoma of the uterus, who received the proposed treatment and prevention measures, the second group — 50 women with leiomyoma of uterus who were administered conventional therapy and the third group comprised 50 healthy women. Bacteriological tests were conducted to assess the species and quantitative composition of vaginal microflora in women after the treatment course of the disorders of autonomic nervous system. Microbiological analyses and recording of the results were carried out in accordance with the Order No. 535 of the Ministry of Health of the USSR, 1985 and the Order of the Ministry of Health of Ukraine No.234 dated May 10, 2007. For prevention and treatment of chronic inflammatory diseases of genital organs exacerbations and in the complex preconception preparation of women with leiomyoma of the uterus, the vaginal suppositories of Api-Norm were administered.
Results. The study of the microbiocenosis changes of the genital tract in women with uterine leiomyoma, who received the vaginal suppository «Api-Norm» in the complex anti-inflammatory therapy, indicated a positive dynamics of opportunistic pathogens and other infectious agents contamination of the genital tract after the treatment compared to the group of women with leiomyoma of uterus, who administered conventional therapy. After the preventive and curative interventions the vaginal biocenosis indicators of patients with uterine leiomyoma, who received the vaginal suppository «Api-Norm» in the complex anti-inflammatory therapy, approached to those of the healthy women. In women with uterine leiomyoma, who prescribed conventional therapy, the vaginal biocenosis indicators after treatment changed less actively and some indicators required the appointment of a refresher cours of treatment.
Conclusions. There is an increase of opportunistic microflora in women of fertile age with uterine leiomyoma, which leads to the development of inflammatory processes of the reproductive organs. Increased contamination of the genital organs by the pathogenic and opportunistic microflora in case of inflammatory diseases requires complex treatment. The inclusion of the vaginal suppositories «Api-Norm» to the complex therapy of inflammatory changes of female genital organs and further prevention of the onset or exacerbation of inflammatory diseases has shown its high efficiency.
Key words: microbiocenosis, women of fertile age, uterine leiomyoma, chronic inflammatory diseases of genital organs, treatment, vaginal suppositories «Api-Norm».

References

1. Benyuk VO, Goncharenko VM, Zabudsky OV et al. (2015). The role of chronic endometritis in the genesis of hyperplastic processes of endometrium. Health of Woman. 6(102): 16-21

2. Human health and demography. The experience of Europe. (2010). World Bank: 72.

3. Ishchenko AI, Botvin MA, Lanchinsky VI. (2010). Uterine myoma: etiology, pathogenesis, diagnosis, treatment. M, Publishing house Viadar-M: 244.

4. Knyazevich VM, Lazorishinets VV, Yakovenko IV et al. (2009). Health care in Ukraine: state, problems, prospects. Kyiv-Ternopil: 440.

5. Korchinskaya OO, Lanna MV. (2013). Prevention of non-pregnancy in women with leiomyoma uterus and pathology of the cervix in anamnesis. Health of woman. 10(86): 100-103.

6. Makarov OV. (2012). Hyperplastic endometrial processes: diagnosis and treatment taking into account the endometrial receptor profile. Obstetrics and gynecology. 3: 32-36.

7. The medical and demographic situation and organization of medical care for the population in 2010: the results of the health care system and the implementation of the Program of Economic Reforms for 2010-2014, "a prosperous society, a competitive economy, an effective state." (2011). K, Ministry of Health of Ukraine: 104.

8. Podolskyy VV, Vovk IB, Kornatskaya AG. (2010). Actual problems of reproductive health of women in Ukraine. Health of woman. 4: 121-126.

9. State of health of the female population in Ukraine in 2009 Ministry of Health. Center of medical statistics. (2010). K.

10. Tatarchuk TF, Kossey NV, Tutchenko TN. (2011). Uterine myoma and reproductive function of women: a critical evaluation of therapeutic approaches. Reproductive Endocrinology. 1: 56-63.

11. Improving Maternal and Perinatal Health: A European Strategic Approach to Safe Pregnancy. (2009). Copenhagen: Who Regional Office for Europe: 51.

12. Fernandez Н. (2011). Update of myoma management – introduction. J Gynecol Obstet Biol Reprod. (Paris). 40; 8: 856.