PERINATOLOGIYA I PEDIATRIYA. 2016.4(68):26-32; doi 10.15574/PP.2016.68.26 
Prevention of reproductive losses in women with systemic lupus erythematosus
Davydova I., Shevchuk E., Limanskaya A., Ogorodnyk A.
SI «Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv

Purpose — to explore the peculiarities of pregnancy and childbirth in women with systemic lupus erythematosus in view of pregravid preparation.
Patients and methods. The study included three groups. I group — 24 pregnant women with systemic lupus erythematosus who received pregravid preparation, group II of 28 pregnant women with systemic lupus erythematosus, have spontaneously pregnancy, III — control group 28 pregnant women without autoimmune diseases. Groups comparable in age, education, eating habits and living in similar climatic conditions. In pregravid preparations include micronized progesterone (utrozhestan in a daily dose of 200 mg of 16 to 25 days of the cycle) when detecting failure II cycle phase — Tivortin in therapeutic dosage, drug containing iodine and folic acid at daily dosages recommended by WHO for preconception period (respectively, 200 mg and 400 mg).
Results. In all three groups there were no spontaneous termination of pregnancy up to 12 weeks. In the first group shows significantly better results when comparing the frequency of pregnancy complications, pregnancy outcomes, metabolic disorders. Conduct prevention of endothelial dysfunction drug Tivortin and continued therapy support L-arginine in the early stages of gestation, in groups of pregnant women with high titers of anti-Ro antibodies, antiphospholipid antibodies, along with prolonged intake of micronized progesterone (utrozhestan), helped to reduce the incidence of hypertensive complications of pregnancy (gestational hypertension, pre!eclampsia) and the birth of children with IUGR or low birth weight for gestational age. Group II women were not able to modify the drug therapy. Pregnant women in this group were receiving corticosteroids due to activation of an autoimmune disease. In some women was the need to enhance the treatment of SLE with corticosteroids in pulse mode using a 2-line therapy in the postpartum period.
Conclusions. Pregnancy in women with systemic lupus erythematosus is a complex task. Women of childbearing age with systemic lupus erythematosus is strongly recommended that preconception counseling and individual approach to the assessment of the risks of obstetric and somatic complications. Multidisciplinary team should be experience of rare, severe extragenital diseases. Pregravid preparation should be used for the preparation of micronized progesterone vaginal administration (utrozhestan). Careful planning pregnancy with specialized experts with experience in the management of these patients, a reasonable pregravid preparation, timely detection of risk factors and prevention of obstetric, somatic and perinatal complications, can achieve success and minimize the maternal and perinatal complications.
Key words: systemic lupus erythematosus, a pregnancy, a multidisciplinary approach, Tivortin, micronized progesterone, Utrozhestan.
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