PERINATOLOGIYA I PEDIATRIYA.2015.2(62):62-65;doi10.15574/PP.2015.62.62

Predictors of the development of the heart failure in children with congenital heart defects after the surgical correction

Dudnyk V. M., Zborovska O. O.

Pirogov National Medical University, Vinnytsia, Ukraine

Purpose — estimated predictors of the development of the heart failure in children with congenital heart defects after the surgical correction due to the evaluation of the results of the tissue doplerography and content of galectin-3 in serum.

Patients and methods. Checked 184 patients with congenital heart defects after the surgical correction with the average age of them 9.54±0.36 years. Duration of the postoperative katamnesis was from 1 month up to 15.3 years. All children were provided with tissue doplerography with evaluation of the myocardial speeds and content of the galectin_3 in serum.

Results. Found that increased content of galectin-3 >6,21 ng/ml increased risk of the clinical manifestation of the heart failure in 1.89 times (95% CI 1.094–4.491).Clinical presentation of the heart failure appeared due to changes of the systolic function of the both ventricles, especially were increased risks of the decreasing of S`mv<7,7 сm/с and S`tv<9,4 сm/с (OR=3.056; 95% CI 1.119–8.350 and OR=3.560; 95% CI 1.236–10.252, in accordance).

Conclusions. Clinical presentation of the heart failure in patients with congenital heart defects after the surgical correction was caused with systolic disorders of the both ventricles, and as well increasing of the marker of the fibrotic process galectin-3.

Key words: congenital heart defects, children, heart failure.