Ukrainian Journal Health of Woman. 2025. 3(178): 86-95. doi: 10.15574/HW.2025.3(178).8695
Kolotilov M. M.¹, Zakomornyy O. S.¹, Omelchenko O. M.¹, Tarasyuk B. A.¹, Zabudska L. R.², Makomela N. M.³, Hlazovska I. I.^1
1SI “All-Ukrainian Center of Maternity and Childhood of the NAMS of Ukraine”, Kyiv
²MNPE “Kyiv City Children’s Clinical Hospital No. 2”, Ukraine
³Oleksandrivskiy Consultative and Diagnostic Center, Kyiv, Ukraine

For citation: Kolotilov MM, Zakomornyy OS, Omelchenko OM, Tarasyuk BA, Zabudska LR, Makomela NM, Hlazovska II. (2025). Posttraumatic stress disorder: a narrative review. Ukrainian Journal Health of Woman. 3(178): 86-95. doi: 10.15574/HW.2025.3(178).8695
Article received: Mar 21, 2025. Accepted for publication: May 21, 2025.

Post-traumatic stress disorder (PTSD) is a syndrome and mental disorder that may develop either immediately or after a delay in adults, adolescents, and children (regardless of ethnicity, nationality, culture, or age) who have experienced or witnessed one or more traumatic events, a series of events, or a set of circumstances.
The aim of this review is to contextualize PTSD within the semantic framework of syndrome description, based on an integrated body of reliable and interrelated knowledge on the subject.
PTSD in children, adolescents, and women is examined through the following dimensions: statistics and epidemiology; clinical symptomatology; diagnostic methods; elements of research methodology; brain growth chart databases and age-normed MRI templates of the brain; target anatomy; genetics; key elements of PTSD pathogenesis; the microbiome; PTSD and comorbidity; PTSD risk prediction; stress resilience; PTSD treatment strategies; pharmacological agents for the prevention and treatment of PTSD; probiotics; evidence-based classical pharmacotherapies; non-recommended pharmacological agents and treatment approaches; and promising directions for future research.
Conclusions. The relevance of research on PTSD is driven by the high prevalence of traumatic events in human life and their consequences, including the development of PTSD. PTSD can adversely affect various aspects of an individual's life, including mental and physical health, social relationships, and overall functioning. The need for continued research in this field is associated with the search for effective methods of diagnosis, treatment, and rehabilitation of individuals suffering from PTSD, as well as with the development of preventive measures aimed at reducing the likelihood of this disorder.
The authors declare no conflict of interest.
Keywords: post-traumatic stress disorder, statistics, epidemiology, clinical symptoms, brain, magnetic resonance imaging, drugs, microbiota, comorbidity.

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