HEALTH OF WOMAN. 2019.1(137):61–63; doi 10.15574/HW.2019.137.61

Rymarchuk М. І.
Ivano-Frankivsk National Medical University

Fetal health depends on both the genetic program of its development and the structural and functional adequacy of placenta.

Materials and methods. Our research envisaged the use of the molecular genetic method to identify deletion and allelic polymorphism of the GSTT1, GSTM1 genes in the homozygous state and the designation of the identified genotypes as the deletion variant (GSTT1 deletion, GSTM1 deletion) or the allelic variant (GSTT1 allele, GSTM1 allelе). The research involved 105 women; among them, there were 50 pregnant women with local non-progressive placental abruption. Group I included 33 women with placental dysfunction, who gave birth to babies with normal body weights; Group II comprised 17 women with placental dysfunction and development delay in their newborn babies.

Results. The study of deletion polymorphism of the GSTT1, GSTM1 genes and A313G polymorphism of the GSTP1 gene in all the women (n=105) (50 patients of the main study groups and 55 women of the control group) revealed the following distribution of polymorphic variants of the studied genes: the GSTT1 allele genotype has made up 81.90%; the GSTT1 deletion genotype was found in 18.10% of cases; the GSTM1 allele genotype was observed in 55.24% of cases; the GSTM1 deletion genotype was detected in 44.76% of women. The frequency of the GSTP1 polymorphic variants was as follows: the АА genotype – 54.29%, the AG genotype – 38.10%, the GG genotype – 9.52%.

Conclusions. The genotype combinations of the GSTT1 allele, GSTM1 allele, 313AA of the GSTT1, GSTM1, GSTP1 genes create no conditions for and clearly reduce the risk of placental dysfunction and intrauterine growth restriction with local non-progressive placental abruption.

Key words: abruption of placenta, genes of detoxification, obstetric complications, polymorphism of genes.

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