SOVREMENNAYA PEDIATRIYA.2016.3(75):70-73; doi10.15574/SP.2016.75.70 

Peculiarities of rickets of children who were born prematurely and suffered bronchopulmonary dysplasia 

Yablon О. S., Rusak N. P.

Vinnytsia National Pirogov Memorial Medical University, Ukraine 

Objective: to establish the clinical and metabolic peculiarities of rickets of children who were born prematurely and suffered bronchopulmonary dysplasia and to evaluate the effectiveness of specific and nonspecific prevention of rickets of these children.

Materials and methods. 15 infants with clinical manifestations of rickets who were born preterm (gestational age 28,87 0,56 weeks, weight 1214,0077 ,91 g) and transferred to the neonatal bronchopulmonary dysplasia (first group) investigated serum total calcium, the level of ionized calcium, inorganic phosphorus in serum, activity of alkaline phosphatase in serum. The results were compared with those of 25 premature babies of the same age and severity of rickets without bronchopulmonary dysplasia (second group) and 10 term infants of the same age and severity of rickets (group).

Results. Children with rickets and osteomalacia bronchopulmonary dysplasia symptoms prevailed, particularly kraniotabes (60.00%) and availability Harissonovoyi grooves (33.33%) (p<0.05), deformity of the sternum (93.33%) and expanding the lower aperture (100.00%) (p<0.01). The data indicate that the depth of metabolic disorders in premature babies with rickets and bronchopulmonary dysplasia fairly similar as prevailing without bronchopulmonary dysplasia of premature babies and of children who were born full-term. The children of the first group all indicators biochemistry blood were significantly lower than similar indicators in children with group comparison, the level of total calcium — 1.84±0.04 mmol/l and inorganic phosphorus — 1.44±0.02 mmol/l (p<0.01), and ionized calcium — 1.06±0.03 mmol/l. The activity of alkaline phosphatase (663.53±55.10 U/L) significantly prevailing rate of term infants (p<0,05). In premature infants antenatal and postnatal prevention of rickets was broken.

Conclusion. It has been established that rickets in premature infants in the background bronchopulmonary dysplasia began earlier, had mostly acute degree course and heavier compared to prematurely without bronchopulmonary dysplasia. In preterm infants with rickets, which underwent bronchopulmonary dysplasia neonatal period, the degree of hypocalcemia, hypophosphatemia was significantly lower, while the index of alkaline phosphatase significantly prevailed. It has been established that the quality of antenatal and postnatal prevention of rickets was unsatisfactory.

Key words: premature babies; rickets; bronchopulmonary dysplasia.

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