- On the issue of early reproductive losses: distribution features of loci HLA II class alleles in couples with recurrent miscarriage in subpopulation in Central and South-Eastern regions of Ukraine
On the issue of early reproductive losses: distribution features of loci HLA II class alleles in couples with recurrent miscarriage in subpopulation in Central and South-Eastern regions of Ukraine
HEALTH OF WOMAN. 2015.9(105):81–84; doi 10.15574/HW.2015.105.81
On the issue of early reproductive losses: distribution features of loci HLA II class alleles in couples with recurrent miscarriage in subpopulation in Central and South-Eastern regions of Ukraine
Veropotvelyan N. P.
The «Inter-provincial center of medical genetics and prenatal diagnosis», Krivoy Rog
273 married couples with a few early reproductive losses (3–11 weeks) in the history of unknown origin was selected. The couple was karyotyped, and in 30% of cases able to obtain information on the karyotype of embryonic structures. All wire pairs SSP-typing of the major histocompatibility complex class II (HLA II class). The results of the research significant similarity in the system HLA II class (3–6 matches) had 22% of couples, with the absence of identical alleles was observed in almost 25% of couples Chromosomal abnormality of the embryo occurs almost 3 times more often in the case of smaller similarity of spouses (0–2 identical alleles). The risk of having homozygous for one of the loci for women 5.3 times and 10 times for men increase in the case of a minimum similarity of spouses (same allele 0–2 / group of alleles).
Key words: early pregnancy loss, HLA ІІ class, embryo karyotype.
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