• Omega-3-polyunsaturated fatty acids in obstetrics and perinatology: actual and controversial issues (clinical lecture) 
en To content

Omega-3-polyunsaturated fatty acids in obstetrics and perinatology: actual and controversial issues (clinical lecture) 

HEALTH OF WOMAN. 2016.1(107):12–17 
 

Omega-3-polyunsaturated fatty acids in obstetrics and perinatology: actual and controversial issues (clinical lecture) 
 

Nazarenko L. G., Nestertsova N. S.

Kharkiv medical Academy of postgraduate education 
 

The goal – to promote the formation of a physician understanding of the mechanisms of action of polyunsaturated fatty acids (PUFAs) in the body to be informed judgments about their potential preventive and therapeutic effects in pregnant women with an increased perinatal risk. Relevance of the topic due to the fact that in recent years there has been a new wave of interest in the use of drugs of natural origin – macro- and micronutrients, vitamins, herbal adaptogens and others. Of particular practical interest PUFAs, especially omega-3- and eykozopentaen dokozogeksaen acids. Its are indispensable because they do not synthesized in the body. There is now evidence that the lack in the diet of these acids may be the cause of many diseases – coronary heart disease, atherosclerosis, hypertensive states, depressive disorders. Obstetrics and Perinatology are among the branches of clinical medicine, where the prospects for the use of PUFAs have not yet been implemented, so it is advisable to consider the sphere of use of omega-3 in the form of micronutrient support, or by prescribing women during gestation. 
 

Key words: fatty acids, dokozogeksapen acid, eykozopentaen acid, pregnancy, prenatal baby. 
 

REFERENCES

1. Bang HO, Dyerberg J. 1980. Lipid Metabolism and Ischemic Heart Disease in Greenland Eskimos. Advances in Nutritional Research 3:1-22.

2. Netrebenko OK. 2012. Programming by nutrition: diet of pregnant women and health of offspring. Pediatrics 91;5:49-57. Нетребенко ОК. 2012.

3. Food and Drug Administration. What you need to know about mercury in fish and shell-fish. Available at: www.csfsan.fda.gov/~dms/admehg3.html. Accwssed June 1. 2008.

4. Fereidooni B, Jenabi E. 2014. The use of omega 3 on pregnancy outcomes: a single-center study. J Pak Med Assoc. 64;12:1363-5.

5. Lim WY et al. 2015. Relations of plasma polyunsaturated Fatty acids with blood pressures during the 26th and 28th week of gestation in women of Chinese, Malay, and Indian ethnicity. Medicine (Baltimore) 94;9:571.

6. Qawasmi A, Landeros-Weisenberger A, Bloch MH. 2012. Meta-analysis of LCPUFA Supplementation of Infant Formula and Visual Acuity. Pediatrics. 2012: 0517.

7. Escamilla-Nuсez MC et al. 2014. Omega-3 fatty acid supplementation during pregnancy and respiratory symptoms in children. Chest. 146;2:373-82. http://dx.doi.org/10.1378/chest.13-1432; PMid:24626819 PMCid:PMC4122276

8. Keenan K, Hipwell AE, Bortner J, Hoffmann A, McAloon R. 2014. Association Between Fatty Acid Supplementation and Prenatal Stress in African Americans: A Randomized Controlled Trial. Obstetrics and Gynecology. 124;6:1080-1087. http://dx.doi.org/10.1097/AOG.0000000000000559; PMid:25415158 PMCid:PMC4241554

9. Avni-Barron O et al. 2010. Preconception Planning to Reduce the Risk of Perinatal Depression and Anxiety Disorders. Expert Rev of Obstet Gynecol. 5;4:421-435. http://dx.doi.org/10.1586/eog.10.27

10. 2002. Institute of Medicine. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids. Washington, DC: National Academy Press.

11. 2005. US Department of Agriculture. My Pyramid. 2008.

12. Olsen SF, Joensen HD. 1985. High live born birth weights in the Faroes: a comparison between birth weights in the Faroes and in Denmark. J Epidemiol Community Health. 39;1:27–32.

13. Klebanoff Mark A et al. 2011. Fish Consumption, Erythrocyte Fatty Acids, and Preterm Birth. Obstetrics and Gynecology. 117:1071-1077. http://dx.doi.org/10.1097/AOG.0b013e31821645dc; PMid:21508745 PMCid:PMC3754827

14. Markides M et al. 2014. Four-Year Follow-up of Children Born to Womenin a Randomized Trial of Prenatal DHA Supplementation. JAMA. 311;17:1802-1804.

15. Odent M. 2001. Preeclampsia as a Maternal-Fetal Conflict. Medscape General Medicine. 3(5):2.

16. Zhou SJ et al. 2012. Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia. Am J ClinNutr. 95;6:1378-84. http://dx.doi.org/10.3945/ajcn.111.033217

17. Mulder KA, King DJ, Innis SM. 2014. Omega-3 fatty acid deficiency in infants before birth identified using a randomized trial of maternal DHA supplementation in pregnancy. PLoS One. 9;1:83764. Doi 10.1371/journal.pone.0083764.

18. Strain JJ et al. 2015. Prenatal exposure to methyl mercury from fish consumption and polyunsaturated fatty acids: associations with child development at 20 mo of age in an observational study in the Republic of Seychelles. Am J ClinNutr. 101;3:530-7. http://dx.doi.org/10.3945/ajcn.114.100503

19. Markides M et al. 2014. Four-YearFollow-up of Children Born to Women in a Randomized Trial of Prenatal DHA Supplementation. JAMA. 311;17:1802-1804.

20. Qawasmi A, Landeros-Weisenberger A, Bloch MH. 2012. Meta-analysis of LCPUFA Supplementation of Infant Formula and Visual Acuity. Pediatrics. Doi 10.1542/peds.2012-0517.

21. Furuhjelm C et al. 2009. Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy. Acta Paediatr. 98;9:1461-7. http://dx.doi.org/10.1111/j.1651-2227.2009.01355.x; PMid:19489765

22. Dunstan JA et al. 2004. The effect of supplementation with fish oil during pregnancy on breast milk immunoglobulin A, soluble CD14, cytokine levels and fatty acid composition. Clin Exp Allergy. 34;8:1237-42. http://dx.doi.org/10.1111/j.1365-2222.2004.02028.x; PMid:15298564

23. Olsen SF et al. 2008. Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial. Am. J. Clin. Nutr. 88;1:167-75.

24. Palmer DJ et al. 2013. Randomized controlled trial of fish oil supplementation in pregnancy on childhood allergies. Allergy. 68;11:1370-6. http://dx.doi.org/10.1111/all.12233; PMid:24111502