SOVREMENNAYA PEDIATRIYA.2014.2(58):107-110; doi 10.15574/SP.2014.58.107 
 

Nonalcoholic fatty liver disease — a component of the metabolic syndrome in the infancy and adolescence 
 

Parkhomenko L. K., Strashok L. A., Buznitskaya E. V., Isakova M. Yu., Zavelya E. M., Eshenko A. V.

Kharkiv Medical Academy of Postgraduate Education, Ukraine 

Objective: To identify early markers of metabolic syndrome in the infancy and adolescence.

Patients and methods. A total of 304 patients with obesity in the age 7–18 years were under observation. Patients underwent anthropometry with the definition of the body mass index, blood lipid study, ultrasound study and also the determination of HOMA index. Biochemical markers of the liver fibrogenesis intensity — fibronectin and type IV collagen in the blood serum were determined by the method of enzyme immunoassay ELISA. 
 

Results. In the 1/3 of children and adolescents with obesity was diagnosed chronic pathology of the hepatobiliary system. In the half of the patients were identified functional disorders of the biliary tract, the symptoms of chronic cholecystitis in — 11% of patients. During the ultrasound study was found an enlarged liver and decreased echogenicity of its parenchyma in 1/4 of patients with obesity, evidently more frequently in adolescents with insulin resistance. In all patients were found signs of moderate atherogenic dyslipidemia, more pronounced at presence of insulin resistance. Examination of the extracellular matrix of liver and fibrogenesis had found a significant increase in the levels of collagen type IV and fibronectin in adolescents with obesity, more pronounced in patients with insulin resistance. 
 

Conclusions. Formation of non-alcoholic fatty liver disease during the obesity in the infancy and adolescence is confirmed by ultrasound study of liver and increased fibrogenesis markers in the blood serum. In all patients with obesity were defined atherogenic changes in lipid profile, more pronounced in the setting of insulin resistance. Obesity and diagnosis of non-alcoholic fatty liver disease may be as an early signs of metabolic syndrome in the infancy and adolescence. 
 

Key words: non-alcoholic fatty liver disease, metabolic syndrome, obesity, children, adolescents. 
 

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