PERINATOLOGIYA I PEDIATRIYA.2015.2(62):74-76; doi10.15574/PP.2015.62.74 
 

Non-celiac gluten sensitivity: is there any reason to worry about? 
 

Tiazhka O. V., Gorobets A. O., Klimchuck V. V., Bogdanova T. A., Levadna L. O.

Natsionalny Medical University named after AA Bogomolets, Kyiv, Ukraine

GU «Road Clinical Hospital № 1 station Kiev DTGO» «South_Western Railway», Kiev, Ukraine 
 

The problems of modern tendencies in gluten related disorders study and their influence upon people's life are reflected in the article. In particular, popularization of gluten free diet (spreading in western countries mainly) and adherence of great number of healthy people to this causeless and, sometimes, harmful habit is discussed. Non-celiac gluten sensitivity — one of gluten related disorders, requiring thorough differential diagnostics with celiac disease is described; peculiarities of its clinical picture, laboratory-and-instrumental and differential diagnostic are depicted. Special attention is paid on the necessity of non-celiac gluten sensitivity study among children's population in Ukraine due to the absence of such studies in pediatric practice of our country. 
 

Key words: children, celiac disease, gluten related disorders, non-celiac gluten sensitivity. 
 

REFERENCES 
1. Губская ЕЮ. 2014. Новое понимание спектра глютензависимых заболеваний. Сучасна гастроентерологія. 1(75): 160—164.

2. Губская ЕЮ, Шевчик АА. 2014. Особенности диагностики непереносимости глютена без целиакии. Гастроэнтерология. 2: 24—25.

3. Коровина НА, Захарова ИН, Лысиков ЮА и др. 2007. Клинические аспекты целиакии у детей. Пос для практических врачей-педиатров. М, МедЭкспертПресс: 79.

4. Майданник ВГ. 2010. Болезни органов пищеварения у детей. Київ, СП «Інтертехнодрук»: 811—887.

5. Cook HB, Burt MJ, Collet JA et al. 2000. Adult celiac disease: prevalence and clinical significance. J Gastroenterol Hepatol. 15: 1032—1036. http://dx.doi.org/10.1046/j.1440-1746.2000.02290.x; PMid:11059933

6. Volta U, Bardella MT, Calabr A et al. 2014. An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity. BMC Medicine. 12: 85. http://dx.doi.org/10.1186/1741-7015-12-85; PMid:24885375 PMCid:PMC4053283

7. Tavakkoli A, Lewis S, Tennyson C et al. 2013.Characteristics of patients who avoid wheat and/or gluten in the absence of celiac disease. Dig Dis Sci. PMCid:PMC3691300

8. Bizzaro N, Tozzoli R, Villalta D et al. 2010. Cutting-edge issues in celiac disease and in gluten intolerance. Clin Rev Allergy Immunol. Published online first: 23 December, 2010.

9. Di Sabatino A, Corazza G. 2012. Nonceliac gluten sensitivity: sense or sensibility? Ann Intern Med. 156: 309—311. http://dx.doi.org/10.7326/0003-4819-156-4-201202210-00010; PMid:22351716

10. Gibson P, Sheperd S. 2012. Food choice as a key management strategy for functional gastrointestinal symptoms. Am J Gastroenterol. 107: 657—666. http://dx.doi.org/10.1038/ajg.2012.49; PMid:22488077

11. Bardella M, Fradella C, Saladino V et al. 2005. Gluten intolerance: gender- and age-related differences in symptoms. Scand J Gastroenterol. 40: 15—19. http://dx.doi.org/10.1080/00365520410008169; PMid:15841709

12. Tanpowpong P, Ingham T, Lampshire P et al. 2012. New Zealand Asthma and Allergy Cohort Study Group. Coeliac disease and gluten avoidance in New Zealand children. Arch Dis Child. 97: 12—16. http://dx.doi.org/10.1136/archdischild-2011-300248; PMid:22075107

13. Volta U, Caio G, Tovoli F, De Giorgio R. 2013. Non-celiac gluten sensitivity: questions still to be answered despite increasing awareness. Cell Mol Immunol. 10: 383—392. http://dx.doi.org/10.1038/cmi.2013.28; PMid:23934026 PMCid:PMC4003198

14. Catassi C, Bai J, Bonaz B et al. 2013. Non-celiac gluten sensitivity: the new frontier of gluten related disorders. Nutrients. 5: 3839—3853. http://dx.doi.org/10.3390/nu5103839; PMid:24077239 PMCid:PMC3820047

15. Oberhuber G, Granditsch G, Vogelsang H. 1999. The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol. 11: 1185—1194. http://dx.doi.org/10.1097/00042737-199910000-00019; PMid:10524652

16. Di Giacomo D, Tennyson C, Green P, Demmer R. 2013. Prevalence of gluten-free diet adherence among individuals without celiac disease in the USA: results from the Continuous National Health and Nutrition Examination Survey. Scand J Gastroenterol. 48: 921—925. http://dx.doi.org/10.3109/00365521.2013.809598; PMid:23834276

17. Biesiekierski J, Rosella O, Rose R et al. 2011. Quantification of fructans, galacto-oligosacharides and other short-chain carbohydrates in processed grains and cereals. J Hum Nutr Diet. 24: 154—176. http://dx.doi.org/10.1111/j.1365-277X.2010.01139.x; PMid:21332832

18. Rewers M. 2005. Epidemiology of celiac disease: What are the prevalence, incidence and progression of the celiac disease? Gastroenterology. 128: 47—51. http://dx.doi.org/10.1053/j.gastro.2005.02.030

19. Sapone A, Bai J, Ciacci C et al. 2012. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med. 10: 13. http://dx.doi.org/10.1186/1741-7015-10-13; PMid:22313950 PMCid:PMC3292448

20. Troncone R, Jabri B. 2011. Coeliac disease and gluten sensitivity. J Intern Med. 269: 582—590. http://dx.doi.org/10.1111/j.1365-2796.2011.02385.x; PMid:21481018

21. Verdu E, Armstrong D, Murray J. 2009. Between celiac disease and irritable bowel syndrome. Am J Gastroenterol. 104: 587—1594. http://dx.doi.org/10.1038/ajg.2009.188; PMid:19455131 PMCid:PMC3480312

22. Walker-Smith J. 1996. Transient gluten intolerance. Arch Dis Child. 74: 183. http://dx.doi.org/10.1136/adc.74.2.183-b; PMid:8660090 PMCid:PMC1511519

23. Junker Y, Zeissig S, Kim S et al. 2012. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med. 209: 2395—2408. http://dx.doi.org/10.1084/jem.20102660; PMid:23209313 PMCid:PMC3526354