Modern Pediatrics. Ukraine. 6(110): 70-78. doi 10.15574/SP.2020.110.70
Banadyha N. V.
I. Horbachevsky Ternopil National Medical University, Ukraine

For citation: Banadyha NV. (2020). A new concept of functional nutrition in early childhood. Modern Pediatrics. Ukraine. 6(110): 70-78. doi 10.15574/SP.2020.110.70
Article received: Aug 15, 2020. Accepted for publication: Oct 07, 2020.

Pediatric aspects of the problem of preservation of each person, above all, are to provide the baby with complete food in terms of the content of essential nutrients necessary for harmonious development, and it must be — functional. New concepts of adequate feeding of young children provide a balanced composition, biological value, multiple preventive effects of food. These requirements are сompletely presented in breastfeeding, which, despite the balanced content of essential nutrients, contains a mixture of biotics (pre-, pro-, synbiotics), among which a special place is — postbiotics. The most studied biotics are pre-, pro-, synbiotics, while postbiotics have not received adequate coverage in the scientific literature for a long time. Postbiotics — a relatively new term, which means biologically active components that are formed during fermentation, including microbial cells, metabolic products. Functional nutrition with the use of postbiotics has certain advantages in terms of safety, biological properties, pharmaceutical effects, compared with the use of live probiotics. At the same time it is possible to avoid risk of translocation of bacteria from intestine to blood, to provide a proper metabolism, stability. At the same time, the use of postbiotics enhances the effect of their own individual microflora, as opposed to the introduction of foreign probiotics into the intestinal lumen, which should be considered as a safe alternative to living probiotic microbes; which motivates the use of functional nutrition in children who do not receive breast milk. In modern conditions, it is already possible to use a mixture of Nutrilon Premium+, characterized by the content of prebiotics (scGOS/lcFOS), postbiotic (including 3'GL), enriched with a complex of vitamins, minerals, increased content of omega-3 and omega-6, which provides harmonious development and has a preventive effect in children who are deprived of the opportunity to receive breast milk.
Conclusions. The use of postbiotics in food (milk formulas) for children of the first years of life provides harmonious physical and psycho+emotional development, has a preventive effect (on functional disorders of the digestive system, infectious and allergic diseases), has a high level of safety and clinical efficacy. The combination of prebiotics (scGOS/lcFOS) and postbiotic — 3-galactosyllactose (3'GL) in new milk formulas has good tolerance, provides multiple prophylactic effects, which determines its functionality and advantages over other dairy formulas.
No conflict of interest was declared by the author.
Key words: children, functional nutrition, postbiotics, prebiotics, probiotics, fermented formulas.

REFERENCES

1. Banadyga NV. (2017). A modern view of the essence of deficiency states in young children. Zaporozhye medical journal. 19 (2): 181–185.

2. Bodemer C, Guillet G, Cambazard F et al. (2017). Adjuvant treatment with the bacterial lysate (OM285) improves management of atopic dermatitis: A randomized study. PLoS ONE.12: e0161555. https://doi.org/10.1371/journal.pone.0161555; PMid:28333952 PMCid:PMC5363804

3. Bunyavanich S, Shen N, Grishin A et al. (2016). Early-life gut microbiome composition and milk allergy resolution. J Allergy Clin Immunol. 138: 1122-1130. https://doi.org/10.1016/j.jaci.2016.03.041; PMid:27292825 PMCid:PMC5056801

4. Carrie AM Wegh, Sharon Y Geerlings, Knol J et al. (2019). Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond. Int J Mol Sci. 20 (19): 4673. https://doi.org/10.3390/ijms20194673; PMid:31547172 PMCid:PMC6801921

5. Chung H, Pamp SJ, Hill JA et al. (2012). Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota. Cell. 149: 1578-1593. https://doi.org/10.1016/j.cell.2012.04.037; PMid:22726443 PMCid:PMC3442780

6. Cortes-Martin A, Selma MV, Tomas-Barberan FA et al. (2020). Where to Look into the Puzzle of Polyphenols and Health The Postbiotics and Gut Microbiota Associated with Human Metabotypes. Mol Nutr Food Res. 64: e1900952. https://doi.org/10.1002/mnfr.201900952; PMid:32196920

7. Crawley PF, Hoyer P, Mazur A, Siderius L, Grosek S, Stiris T, Neubauer D. (2017, Apr). Health, integrity, and doping in sports for children and young adults. A resolution of the European Academy of Paediatrics. European Journal of Pediatrics. 176: 825-828. URL: https://link.springer.com/article/10.1007/s00431-017-2894-z. https://doi.org/10.1007/s00431-017-2894-z; PMid:28365828

8. Esposito S, Soto-Martinez ME, Feleszko W et al. (2018). Nonspecific immunomodulators for recurrent respiratory tract infections, wheezing and asthma in children: A systematic review of mechanistic and clinical evidence. Curr Opin Allergy Clin Immunol. 18: 198-209. https://doi.org/10.1097/ACI.0000000000000433; PMid:29561355 PMCid:PMC6037280

9. Fiocchi A, Pawankar R, Cuello-Garcia C, Ahn K, Al-Hammadi S, Agarwal A, Beyer K, Burks W, Canonica WG, Ebisawa M, Gandhi S, Kamenwa R, Bee Wah Lee, Haiqi Li, Prescott S, Riva JJ, Rosenwasser L, Sampson H, Spigler M, Terracciano L, Vereda-Ortiz A, Waserman S, Yepes-Nunez JJ, Brozek LJ, Schunemann JH. (2015, Jan). World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics. World Allergy Organization Journal. 8: 1-13. URL: https://waojournal.biomedcentral.com/articles/10.1186/s40413-015-0055-2. https://doi.org/10.1186/s40413-015-0055-2; PMid:25628773 PMCid:PMC4307749

10. Furusawa Y, Obata Y, Fukuda S et al. (2013, Dec 19). Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 504 (7480): 446-450. https://doi.org/10.1038/nature12721; PMid:24226770

11. Haileselassie Y, Navis M, Nam Vu. (2016). Postbiotic Modulation of Retinoic Acid Imprinted Mucosal-like Dendritic Cells by Probiotic. Lactobacillus reuteri 17938 In Vitro. Front Immunol. 7: 96. https://doi.org/10.3389/fimmu.2016.00096; PMid:27014275 PMCid:PMC4794487

12. Hoarau C, Martin L, Faugaret D et al. (2008). Supernatant from Bifidobacterium Differentially Modulates Transduction Signaling Pathways for Biological Functions of Human Dendritic Cells. PLoS ONE. 3: e2753. https://doi.org/10.1371/journal.pone.0002753; PMid:18648505 PMCid:PMC2447180

13. Huet F, Abrahamse-Berkeveld M, Tims S et al. (2016, Oct). Partly fermented infant formulae with specific oligosaccharides support adequate infant growth and are well-tolerated. J Pediatr Gastroenterol Nutr. 63 (4): e432e53. https://doi.org/10.1097/MPG.0000000000001360; PMid:27472478 PMCid:PMC5051523

14. Imperial ICVJ, Ibana JA. (2016). Addressing the Antibiotic Resistance Problem with Probiotics: Reducing the Risk of Its Double-Edged Sword Effect. Front Microbiol. 7: 1983. https://doi.org/10.3389/fmicb.2016.01983; PMid:28018315 PMCid:PMC5156686

15. Izuddin WI, Humam AM, Loh TC et al. (2020). Dietary Postbiotic Lactobacillus plantarum Improves Serum and Ruminal Antioxidant Activity and Upregulates Hepatic Antioxidant Enzymes and Ruminal Barrier Function in Post-Weaning Lambs. Antioxidants. 9: 250. https://doi.org/10.3390/antiox9030250; PMid:32204511 PMCid:PMC7139658

16. Jensen G, Benson K, Carter S et al. (2010). GanedenBC30™ cell wall and metabolites: Anti-inflammatory and immune modulating effects in vitro. BMC Immunol. 11: 15. https://doi.org/10.1186/1471-2172-11-15; PMid:20331905 PMCid:PMC2858026

17. Jeong K, Kim M, Jeon SA et al. (2020). A randomized trial of Lactobacillus rhamnosus IDCC 3201 tyndallizate (RHT3201) for treating atopic dermatitis. Pediatric allergy and immunology. 07 (31): 783-792. https://doi.org/10.1111/pai.13269; PMid:32363613

18. Kasahara K, Krautkramer KA, Org E et al. (2018). Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model. Nat Microbiol. 3: 1461-1471. https://doi.org/10.1038/s41564-018-0272-x; PMid:30397344 PMCid:PMC6280189

19. Koatz AM, Coe NA, Ciceran A et al. (2016). Clinical and Immunological Benefits of OM-85 Bacterial Lysate in Patients with Allergic Rhinitis, Asthma, and COPD and Recurrent Respiratory Infections. Lung. 194: 687-697. https://doi.org/10.1007/s00408-016-9880-5; PMid:27117798 PMCid:PMC7087659

20. Lei X, Zhang H, Hu Z et al. (2018). Immunostimulatory activity of exopolysaccharides from probiotic Lactobacillus casei WXD030 strain as a novel adjuvant in vitro and in vivo. Food Agric Immunol. 29: 1086-1105. https://doi.org/10.1080/09540105.2018.1513994

21. Lyons KE, Ryan CA, Dempsey EM et al. (2020). Breast Milk, a Source of Beneficial Microbes and Associated Benefits for Infant Health Nutrients. 12 (4): 1039. https://doi.org/10.3390/nu12041039; PMid:32283875 PMCid:PMC7231147

22. Malagon-Rojas JN, Mantziari A, Salminen S et al. (2020). Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review. Nutrients. 12 (2): 89. https://doi.org/10.3390/nu12020389; PMid:32024037 PMCid:PMC7071176

23. Morisset M, Aubert-Jacquin C, Soulaines P et al. (2011). A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy. Eur J Clin Nutr. 65: 175-183. https://doi.org/10.1038/ejcn.2010.250; PMid:21081959

24. Moro G, Boehm G. (2012). Clinical Outcomes of Prebiotic Intervention Trials during Infancy: A Review. Functional Food Reviews. 4 (3): 101-113. doi: 10.2310/6180.2012.00028.

25. Nataraj BH, Azmal Ali S, Behare PV et al. (2020). Postbiotics-parabiotics: the new horizons in microbial biotherapy and functional foods. Microb Cell Fact. 19: 168. https://doi.org/10.1186/s12934-020-01426-w; PMid:32819443 PMCid:PMC7441679

26. Newburg D, Ko J, Leone S et al. (2015, Feb). Human Milk Oligosaccharides and Synthetic Galactosyloligosaccharides Contain 3'2, 42, and 6'-Galactosyllactose and Attenuate Inflammation in Human T84, NCM2460, and H4 Cells and Intestinal Tissue Ex Vivo. J Nutr. 146 (2): 358-367. https://doi.org/10.3945/jn.115.220749; PMid:26701795 PMCid:PMC4725434

27. Nocerino R, Paparo L, Terrin G et al. (2017). Cow's milk and rice fermented with Lactobacillus paracasei CBA L74 prevent infectious diseases in children: A randomized controlled trial. Clin Nutr. 36: 118-125. https://doi.org/10.1016/j.clnu.2015.12.004; PMid:26732025

28. Puccetti M, Xiroudaki S, Ricci M et al. (2020). Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline Pharmaceutics. 12 (7): 624. https://doi.org/10.3390/pharmaceutics12070624; PMid:32635461 PMCid:PMC7408102

29. Rodriguez-Herrera A, Mulder K, Bouritius H et al. (2019). Gastrointestinal Tolerance, Growth and Safety of a Partly Fermented Formula with Specific Prebiotics in Healthy Infants: A Double-Blind, Randomized, Controlled Trial. Nutrients. 11 (7): 1530. https://doi.org/10.3390/nu11071530; PMid:31284424 PMCid:PMC6683277

30. Rossoni RD, Pimentel de Barros P, Mendonca IC et al. (2020). The Postbiotic Activity of Lactobacillus paracasei 28.4 Against Candida auris. Front Cell Infect Microbiol. 10: 397. https://doi.org/10.3389/fcimb.2020.00397; PMid:32850495 PMCid:PMC7417517

31. Salminen S, Stahl B, Vinderola G. et al. (2020). Infant Formula Supplemented with Biotics: Current Knowledge and Future Perspectives. Nutrients. 12 (7): 1952. https://doi.org/10.3390/nu12071952; PMid:32629970 PMCid:PMC7400136

32. Singh P, Saini P. (2017). Food and Health Potentials of Exopolysaccharides Derived from Lactobacilli. Microbiol Res J Int. 22 (2): 1-14. https://doi.org/10.9734/MRJI/2017/36935

33. Vandenplas Y, Ludwig T, Bouritius H et al. (2017). Randomised controlled trial demonstrates that fermented infant formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides reduces the incidence of infantile colic. Acta Pediatrica. 106 (7): 1150-1158. https://doi.org/10.1111/apa.13844; PMid:28328065 PMCid:PMC5485044

34. World Gastroenterology Organisation. (2020). Global guidelines. URL: https://www.worldgastroenterology.org/guidelines/global-guidelines.

35. Yin J, Xu B, Zeng X et al. (2018). Broncho-Vaxom in pediatric recurrent respiratory tract infections: A systematic review and meta-analysis. Int Immunopharmacol. 54: 198-209. https://doi.org/10.1016/j.intimp.2017.10.032; PMid:29154122

36. Zadeh M, Khan M, Goh Y et al. (2012). Induction of intestinal pro-inflammatory immune responses by lipoteichoic acid. J Inflamm (Lond Engl). 9: 7. https://doi.org/10.1186/1476-9255-9-7; PMid:22423982 PMCid:PMC3325164

37. Zolkiewicz J, Marzec A, Ruszczyski M et al. (2020, Aug). Postbiotics – A Step Beyond Pre- and Probiotics. Nutrients. 12 (8): 2189. https://doi.org/10.3390/nu12082189; PMid:32717965 PMCid:PMC7468815