SOVREMENNAYA PEDIATRIYA.2016.6(78):46-50; doi 10.15574/SP.2016.78.46 

N-terminal brain natriuretic peptide in children with different forms of primary hypertension 

Marushko Y., Hysсhak T.

Bogomolets National Medical University, Kiev, Ukraine

Background. The serum level of NT-proBNP plays a significant role in the regulation of intravascular volume and vascular tone. Current study includes children with primary hypertension (PAH).

Aims. The aim of the study is to investigate the level of serum NT-proBNP in children with various forms of primary hypertension (PAH) and prognostic significance for the development of myocardial dysfunction in children depending on the form of PAH.

Objectives. The study involved 71 children at the age of 9–17 years old, among them — 53 with PAH and 18 — with normal blood pressure.

Methods. All children underwent general clinical examination, ambulatory blood pressure monitoring (ABPM), echocardiography, determination of NT-proBNP in serum by ELISA.

Results. The serum NT-proBNP level in children with degree II PAH was 31.23±9.32 fmol/ml, with degree I PAH — 59.48±20.73 fmol/ml, which was higher than in control group (12.48±2.18 fmol/ml, p<0.05). Among the 7 children with EF less than 55% only one child's NT-proBNP level was higher than 300 fmol/ml. Concentric LV remodeling was observed in 32.3±8.4% of children with stable PAH and 22.7±8.9% of labile PAH. The NT-proBNP increase in serum of females occurs at stage II PAH, in males – already at stage I PAH; systolic dysfunction in children with PAH is rare and it is accompanied with increased levels of NT-proBNP above 300 fmol/ml.

Key words: NT-proBNP; Children; Primary hypertension.

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