Health of woman. 2015.1(97):195–198; doi 10.15574/HW.2015.97.195 
 

Morphological features of ovaries of rats with experimental hypovitaminosis D3 
 

Tatarchuk T. F., Zadorozhna T. D., Kapshuk I. N., Opuhovskaya L. I., Borisova T. A., Trikash I. O., Tarnapolska V. O.

SI «Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine», Kiev

Institute of biochemistry. A. V. Palladin of NAS of Ukraine», Kyiv

Zhytomyr oblast perinatal center of Zhytomyr regional Council 
 

The paper presents the results of the study of specific morphological features of the ovaries of rats in the condition of experimental hypovitaminosis D3. It was found that morphologically ovaries of rats exposed to experimental D3 hypovitaminosis are characterized by the impairment of follicular maturation, formation of cysts, absence of corpora luthea, vescular remodelation as well as increase of colagenization and prevalence of stromal component. 
 

Key words: polycystic ovary syndrome, vitamin D, rat, ovaries. 
 

REFERENCES

1. Heaney R.P. 2008. Vitamin D in health and disease. Clin J Am Soc Nephrol 3:1535–1541. http://dx.doi.org/10.2215/CJN.01160308; PMid:18525006

2. Li HW, Brereton RE, Anderson RA, Wallace AM, Ho CK. Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovarysyndrome. Metabolism. 2011;60:1475–1481 Wehr E, Trummer O, Giuliani A, Gruber HJ, Pieber TR, Obermayer-Pietsch B. http://dx.doi.org/10.1016/j.metabol.2011.03.002; PMid:21550088

3. Yildizhan R at all. 2011. Vitamin D-associated polymorphisms are related to insulin resistance and vitamin D deficiency in polycystic ovary syndrome. Eur J Endocrinol 164(5):741–749. http://dx.doi.org/10.1530/EJE-11-0134; PMid:21389086

4. Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome. Archives of Gynecology and Obstetrics, 2009. 280, 559–563. http://dx.doi.org/10.1007/s00404-009-0958-7; PMid:19214546

5. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. 2000. Decreased bioavailability ofvitamin D in obesity. American Journal of Clinical Nutrition 72:690–693. PMid:10966885

6. Grundmann M., & von Versen-Hцynck F. (2011). Vitamin D – roles in women’s reproductive health? Reproductive Biology and Endocri-nology: RB&E, 9(1), 146. http://dx.doi.org/10.1186/1477-7827-9-146.

7. Hahn S, Haselhorst U, Tan S, Quadbeck B, et al. 2006. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Experimental and Clinical Endocrinology and Diabetes.

8. Panidis D, Balaris C, Farmakiotis D, Rousso D, Kourtis A, Balaris V, Serum parathyroid hormone concentrations are increased in women with polycystic ovary syndrome. Clinical Chemistry, 2005 Ranjzad F, Mahban A, Shemirani AI, Mahmoudi T, Vahedi M, Nikzamir A, Zali MR.

9. Influence of gene variants related to calcium homeostasis on biochemical parameters of women with polycystic ovary syndrome. Journal of Assisted Reproduction and Genetics. 2011. 28:225–232. http://dx.doi.org/10.1007/s10815-010-9506-4; PMid:21082232 PMCid:PMC3082662

10. Parikh G, Varadinova M, Suwandhi P, Araki T, et al. 2010. Vitamin D regulates steroidogenesis and insulin-like growth factor binding protein-1 (IGFBP-1) production in human ovarian cells.Hormone and Metabolic Research 42:754–75. http://dx.doi.org/10.1055/s-0030-1262837; PMid:20711952

11. Mahmoudi T. 2009. Genetic variation in the vitamin D receptor and polycystic ovary syndrome risk. Fertil Steril 92(4):1381–1383. http://dx.doi.org/10.1016/j.fertnstert.2009.05.002; PMid:19501823

12. Wehr E, Pieber TR, Obermayer-Pietsch B. 2011. Effect of vitamin D3 treatmenton glucose metabolism and menstrual frequency in PCOS women-a pilot study. J Endocrinol Invest. PMid:21613813

13. Thys-Jacobs S, Donovan D, Papadopoulos A, Sarrel P, Bilezikian JP. 1999. Vitamin D and calcium dysregulation in the polycystic ovarian syndrome. Steroids 64(6):430–435. http://dx.doi.org/10.1016/S0039-128X(99)00012-4

14. Rashidi B, Haghollahi F, Shariat M, Zayerii F. 2009. The effects of calcium-vitamin D and metformin on polycystic ovary syndrome: a pilot study. Taiwan J Obstet Gynecol 48(2):142–147. http://dx.doi.org/10.1016/S1028-4559(09)60275-8

15. J Ott, L Wattar, C Kurz, R Seemann, JC Huber Parameters for calcium metabolism in women with polycystic ovary syndrome who undergo clomiphene citrate stimulation: a prospective cohort study. European Journal of … 2012. EFES.

16. Dolci S & Siracusa G An increase of intracellular free Ca2+ is essential for spontaneous meiotic resumption by mouse oocytes. Journal of Experimental Zoology. 1991. 260, 401–405. http://dx.doi.org/10.1002/jez.1402600314; PMid:1744620

17. Резніков О.Г., Ганжій І.Ю., Полякова Л.І., Носенко Н.Д., Сініцин П.В., Тарасенко Л.В., Лимарєва А.А., Чайковська Л.В. 2009. Вплив тестостерону та блокатора андрогенних рецепторів, застосованих під час пубертації, на гістологічну будову органів статевої системи самиць щурів. Патологія 6;2.

18. Смирнова С.Н. 2013. Функциональная морфология яичников в условиях измененного гомеостаза на разных стадиях онтогенеза у белых крыс при СПКЯ. Таврический медико-биологический вестник 16;1,ч.1(61):228–231.