SOVREMENNAYA PEDIATRIYA.2018.6(94):22-26; doi 10.15574/SP.2018.94.22

Klymenko V. A., Drobova N. M., Piontkovska O. V., Pasichnyk O. V.
Kharkiv National Medical University, Ukraine
Kharkiv Regional Clinical Children's Hospital No.1, Ukraine

Cystic fibrosis (CF) is a genetic disease with a multiple organ type of lesion. Liver cirrhosis is ranked the third in the general list of death causes in CF patients. The purpose of the study was to improve medical care for patients with CF by treatment individualization according to the prognosis of the gastrointestinal tract complications development. The study was performed on 42 children with CF. Patients were divided into 2 groups: group A (with liver cirrhosis) and group B (control, without or with moderate organic liver damage). One hundred twelve indicators were analyzed. After that the logistic regression method with the step-by-step incorporation of predictors was used to analyze the features and to select meaningful criteria for the mathematical model creation. The mathematical model for predicting of the liver cirrhosis development in children with CF was created. It should help to make an individual algorithm for treating using non-specific research methods in order to prevent the progression of liver damage in patients with CF.

Key words: children, cystic fibrosis, liver cirrhosis, mathematical model, predicting.

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Article received: May 05, 2018. Accepted for publication: Oct 15, 2018.