HEALTH OF WOMAN. 2016.5(111):77–82; doi 10.15574/HW.2016.111.77 
 

Mechanisms of adaptation of the pregnant women with miscarriage in the dynamics of the saving therapy 
 

Potapov V. O., Zharkih A. V., Susjuka V. G., Plotnik V. O.

SI «Dnipropetrovsk medical Academy of MH of Ukraine»

Zaporozhzhia state medical University

The aim of the study: to evaluate the impact of the saving therapy in the implementation of adaptive mechanisms in pregnant women with recurrent pregnancy loss based on the study of the psycho-emotional state, autonomic balance and hormonal profile.

Materials and methods. There were surveyed 67 pregnant women at the gestational age of 7-14 weeks with singleton pregnancy. The main group consisted of 35 women with threatening abortion clinic who were treated in the gynecological Department of the hospital № 9 Zaporozhye city and received natural micronized PG Utrozhestan® (Besins Healthcare) vaginally 200 mg twice a day. The control group consisted of 32 women without clinical manifestations of threatened abortion. The inclusion criteria were complaints of pain in lower abdomen and poor or moderate bleeding from the genital tract on the background of intrauterine pregnancy. Exclusion criteria were: hyperandrogenism, polycystic ovarian syndrome, menstrual irregularities, anomalies development of genital organs, habitual miscarriage, presence of fetal malformations and pregnancy with a copious bloody discharge.

Results. Found that in pregnant women with threatening abortion clinic there is an increase of reactive anxiety, which is caused by an emotional reaction to a stressful situation and evidence of psycho-emotional maladjustment. Given that more than half of pregnant women with the clinic of miscarriage have a high level of personal anxiety, which is stable individual characteristics and reflects the predisposition of a subject to anxiety, this fact should be considered as a risk factor for this disease. Violations of the hormonal balance in pregnant women with recurrent pregnancy loss, characterized by increasing levels of cortisol and cortisone-insulin index, which is a stress response in this population of pregnant women. Similar changes are characteristic for the system mother-placenta-fetus that are caused by the decreased levels of estriol.

Conclusion. Saving therapy using vaginal micronized progesterone (Utrozhestan®), including in the group of pregnant women with a poor prognosis (the presence of retrohorial hematoma), has a positive impact on the normalization of psycho-emotional state, autonomic balance, hormonal profile, and is also characterized by a lack of androgenic activity, which gives grounds to recommend cough medicine® for inclusion in the scheme of treatment of miscarriage.

Key words: surrogacy pregnancy, autonomic regulation, level of anxiety, the hormonal profile, stress, adaptation, treatment, Utrozhestan®.

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