HEALTH OF WOMAN.2017.1(117):34–36; doi 10.15574/HW.2017.117.34

Shcherbina N. A., Demidenko D. I., Demidenko A. D., Kapustnik N. V.
Kharkiv national medical University

Under our supervision there were 66 women with a diagnosis of "dysplasia of cervical epithelium mild" on the background of persistent human papillomavirus infection (PVI). With the aim of improving the treatment of dysplasia of the 1st degree in rehabilitation activities after cryoablation there were applied drugs Distreptaza and inducer of interferon. The results of treatment were evaluated after 3 months. For patients of the 1st group (18 women) who underwent only cryoablation, the efficacy of therapy was 77.8%. In the 2nd group (22 women) after cryoablation was used inducer of interferon, the effectiveness  made up of 90.9%. The maximum effect of treatment – 100% recorded in 3rd group (26 patients), where after cryoablation was carried out treatment with Distreptaza and inducer of interferon. The results of treatment obtained in this group allow to recommend the complex therapy of PVI in conditions of female consultation.

Key words: dysplasia, HPV, cryosurgery, Distreptaza, inducer of interferon.

REFERENCES
1. Tuzankina IA, Kuznetsova YuN, Gerasimova NM. 2005. Sostoyanie immunnoy sistemyi patsientok s persistiruyuschim i tranzitornyim varintami techeniya latentnoy papillomavirusnoy infektsii sheyki matki, obuslovlennoy onkogennyimi tipami virusa papillomyi cheloveka. Immunologiya 26;4:221–225.
2. Oboskalova TA, Kononova IN, Voroshilina ES, Kuzina TV. 2012. Reshitelno i navsegda. Effektivnost reabilitatsionnyih meropriyatiy posle destruktivnogo lecheniya sheyki matki. Akusherstvo i ginekologiya 2:86–89.
3. Scherbina NA, Demidenko DI, Demidenko AD. 2013. Printsipyi vedeniya patsientov s papillomavirusnoy infektsiey bez klinicheskih proyavleniy v usloviyah zhenskoy konsultatsii. Akusherstvo i ginekologiya: 174–180.
4. Ershov FI, Isakov VA, Bekker GP i dr. 2008. Primenenie Allokin-alfa v terapii virusnyih infektsiy. Rukovodstvo dlya vrachey: 140.
5. Instruktsiya dlya medichnogo zastosuvannya preparatu Distreptaza. Nakaz MOZ Ukrayini vid 21.10.11 № 685. Reestrativne posvidchennya № IA/5275/01/01.
6. Zolotov IS, Ostroshenskiy VV. 2014. Terapiya vospalitelnyih zabolevaniy zhenskih polovyih organov: Vozmozhnosti immunomodulyatorov. Ginekologiya 3:86–90.
7. Zielinski GD, Rozendal L, Voorhorst FI et al. 2003, oct. HPV testing can reduel the number of follow-up visits in women treated for cervical intraepithelial neoplasia grade 3. Gynecol. Oncol. 91(1):67–73. https://doi.org/10.1016/S0090-8258(03)00415-3